Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]
Communications BiologyThe VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh +4 more
doaj +2 more sources
Environmental Microbiology, 2017 Summary When abruptly exposed to toxic levels of hexavalent uranium, the extremely thermoacidophilic archaeon Metallosphaera prunae , originally isolated from an abandoned uranium mine, ceased to grow, and concomitantly exhibited heightened levels of cytosolic ribonuclease ...
Arpan, Mukherjee +5 more
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Crystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN‐domain (VapC) protein from a toxin‐antitoxin operon [PDF]
Proteins: Structure, Function, and Bioinformatics, 2008 Crystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN-domain (VapC) protein from a toxin-antitoxin operon Richard D. Bunker, Joanna L. McKenzie, Edward N. Baker, and Vickery L. Arcus* 1Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand ...
Richard D, Bunker +3 more
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Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin [PDF]
mBio, 2023 A type II VapB14 antitoxin regulates biofilm dispersal in the archaeal thermoacidophile Sulfolobus acidocaldarius through traditional toxin neutralization but also through noncanonical transcriptional regulation.
April M. Lewis +5 more
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Masking of errors in transmission of VAPC-coded speech [PDF]
, 1990 A subjective evaluation is provided of the bit error sensitivity of the message elements of a Vector Adaptive Predictive (VAPC) speech coder, along with an indication of the amenability of these elements to a popular error masking strategy (cross frame ...
Cox, Neil B., Froese, Edwin L.
core +2 more sources
The N-terminal domain is required for cell surface localisation of VapA, a member of the Vap family of Rhodococcus equi virulence proteins. [PDF]
PLoS ONERhodococcus equi pneumonia is an important cause of mortality in foals worldwide. Virulent equine isolates harbour an 80-85kb virulence plasmid encoding six virulence-associated proteins (Vaps).
Raúl Miranda-CasoLuengo +6 more
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VapCs of Mycobacterium tuberculosis Cleave RNAs Essential for Translation:VapCs of M. tuberculosis cleave tRNAs and 23S rRNA [PDF]
, 2016 The major human pathogen Mycobacterium tuberculosis can survive in the host organism for decades without causing symptoms. A large cohort of Toxin-Antitoxin (TA) modules contribute to this persistence. Of these, 48 TA modules belong to the vapBC (virulence associated protein) gene family. VapC toxins are PIN domain endonucleases that, in Enterobacteria,
Tollervey, David +3 more
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Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. [PDF]
PLoS ONE, 2014 Bacteria have evolved mechanisms that allow them to survive in the face of a variety of stresses including nutrient deprivation, antibiotic challenge and engulfment by predator cells.
Brooke Hamilton +4 more
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MicrobiologyOpen, Volume 12, Issue 4, August 2023., 2023 Klebsiella pneumoniae is an opportunistic pathogen frequently associated with antibiotic resistance and present in a wide range of environments. In this study, five antibiotic‐resistant K. pneumoniae isolates recovered from bivalves, of which four also carried heavy metal resistance genes, were selected for complete genome sequencing.
Fredrik Håkonsholm +4 more
wiley +1 more source
Commonality of Virulence‐Promoting Function in Rhodococcus equi Virulence Associated Proteins (Vaps)
Cellular Microbiology, Volume 2023, Issue 1, 2023., 2023 Rhodococcus equi is a Gram‐positive facultative intracellular pathogen associated with life‐threatening bronchopneumonial disease in foals. Key to R. equi’s intracellular survival in host macrophages is the production of virulence associated proteins (Vaps).
Timothy R. Ganderton +7 more
wiley +1 more source