Results 41 to 50 of about 8,222 (211)

Therapeutic potential of vardenafil in preventing sepsis-induced kidney injury: a preclinical study [PDF]

Pharmacia
Sepsis is caused by an infection-induced systemic inflammatory response that may lead to organ failure and death. This study aimed to evaluate the nephroprotective effect of vardenafil, a selective PDE-5 inhibitor, in preventing sepsis-induced kidney ...
Ghanim Al-ghanimi, Ali M. Janabi
doaj   +3 more sources

Overcoming multiple drug resistance mechanisms in medulloblastoma [PDF]

, 2014
Introduction: Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients.
Andrey Korshunov, Beth Coyle, Ian D Kerr, Ioanna Kimishi, Lisa CD Storer, Othman, Ramadhan T, Ramadhan RamadhanT Othman, Richard G Grundy, Stefan M Pfister, Tracey D Bradshaw   +9 more
core   +1 more source

Ethosome-Derived Invasomes as a Potential Transdermal Delivery System for Vardenafil Hydrochloride: Development, Optimization and Application of Physiologically Based Pharmacokinetic Modeling in Adults and Geriatrics

International Journal of Nanomedicine, 2020
Aim The aim of the current work was to develop vardenafil hydrochloride (VRD)-loaded ethosome-derived invasomes as a possible transdermal system which could be used for patients suffering from pulmonary arterial hypertension. Methods VRD-loaded ethosomes
H. Ammar, M. I. Tadros, Nahla M. Salama, A. Ghoneim   +3 more
semanticscholar   +1 more source

Effects of different vardenafil doses on bone healing in a rat fracture model

Joint Diseases and Related Surgery, 2021
Objectives We aimed to investigate the radiological, biomechanical, histopathological, histomorphometric, and immunohistochemical effects of different doses of vardenafil on fracture healing.
Tolgahan Atçı, Ender Alagöz, Elif Yaprak Saraç, Hakan Özbay, Mustafa Fatih Daşcı, Abdurrahman Acar, Derya Karabulut, Mehmet Akif Güleç   +7 more
semanticscholar   +1 more source

Long-Term PDE-5A Inhibition Improves Myofilament Function in Left and Right Ventricular Cardiomyocytes through Partially Different Mechanisms in Diabetic Rat Hearts

Antioxidants, 2021
Heart failure with preserved ejection fraction (HFpEF) and right ventricular (RV) dysfunction are frequent complications of diabetic cardiomyopathy. Here we aimed to characterize RV and left ventricular (LV) remodeling and its prevention by vardenafil (a
Beáta Bódi, Árpád Kovács, Hajnalka Gulyás, Lilla Mártha, Attila Tóth, Csaba Mátyás, Bálint András Barta, Attila Oláh, Béla Merkely, Tamás Radovits, Zoltán Papp   +10 more
doaj   +1 more source

The efficacy of bosentan combined with vardenafil in the treatment of postoperative pulmonary hypertension in children with congenital heart disease

Medicine, 2021
Background: Congenital heart disease in children with pulmonary hypertension is a common and serious complication, which has a direct impact on the surgical effect and prognosis of children.
Chao Gao, Junting Liu, Runhan Zhang, Manting Zhao, Yongli Wu   +4 more
semanticscholar   +1 more source

The effects of vardenafil and pentoxifylline administration in an animal model of ischemic colitis

Clinics, 2014
OBJECTIVES: Vardenafil enhances dilatation of vascular smooth muscle and inhibits platelet aggregation. The purpose of this study was to evaluate the clinical effects of vardenafil and pentoxifylline administration in an experimental model of ischemic ...
Mehmet Aziret, Oktay Irkorucu, Enver Reyhan, Hasan Erdem, Koray Das, Selvinaz Ozkara, Ali Surmelioglu, Selim Sozen, Ilhan Bali, Sulleyman Cetinkunar, Kamuran Cumhur Deger   +10 more
doaj   +1 more source

P4.09 EFFECT OF VARDENAFIL ON ARTERIAL STIFFNESS AND WAVE REFLECTION

Artery Research, 2009
Introduction: While vardenafil is widely prescribed for erectile dysfunction, its effect on arterial function is not established. Arterial stiffness and wave reflections are markers of cardiovascular disease and predictors of cardiovascular risk.
D. Terentes-Printzios, C. Vlachopoulos, N. Ioakeimidis, K. Rokkas, K. Aznaouridis, K. Baou, C. Stefanadis   +6 more
doaj   +1 more source

Screening and Determination of Synthetic PDE-5 Inhibitors in Adulterated Sexual Enhancement Supplements

Molecules, 2022
This paper reports an important investigation and quantification of adulteration of sexual enhancement supplements with prescription medicines available in United Arab Emirates (UAE): tadalafil, sildenafil and vardenafil.
Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Sa’ed H. Zyoud, Baharudin Ibrahim, Samer H. Zyoud   +5 more
doaj   +1 more source

Hemodynamic and Pharmacokinetic Interactions of TPN171 with Alcohol in Healthy Male Subjects. [PDF]

Clin Transl Sci
ABSTRACT This study aimed to evaluate the effects of the concomitant administration of TPN171 and alcohol on hemodynamic and pharmacokinetic characteristics in healthy Chinese male subjects. Fifteen eligible subjects were randomly assigned to one of three sequences, each comprising three treatments: Treatment A (placebo +0.5 g/kg alcohol), Treatment B (
Cheng J, Qian H, Wang Y, Liang L, Xu W, Liu Y, Chen Q, Yu C, Duan H, Wang Z, Wang H, Jia J.   +11 more
europepmc   +2 more sources