Results 71 to 80 of about 1,091 (176)

In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus [PDF]

, 2022
Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom ...
Alsolaiss, Jaffer, Casewell, Nicholas R., Clare, Rachel H., Crittenden, Edouard, Edge, Rebecca J., Hall, Steven R., Harrison, Robert A., Kool, Jeroen, Marriott, Amy E., Menzies, Stefanie K., Westhorpe, Adam, Xie, Chunfang   +11 more
core   +6 more sources

Snakebite: An Exploratory Cost-Effectiveness Analysis of Adjunct Treatment Strategies. [PDF]

, 2018
The cost-effectiveness of the standard of care for snakebite treatment, antivenom, and supportive care has been established in various settings. In this study, based on data from South Indian private health-care providers, we address an additional ...
Bulfone, Tommaso C, Herzel, Benjamin J, Kahn, James G, Lewin, Matthew, Raj, C Soundara, Samuel, Stephen P   +5 more
core   +2 more sources

Human Group IIA Phospholipase A2 : three decades on from its discovery [PDF]

, 2021
Phospholipase A2 (PLA2) enzymes were first recognized as an enzyme activity class in 1961. The secreted (sPLA2) enzymes were the first of the five major classes of human PLA2s to be identified and now number nine catalytically-active structurally ...
Bryant, Katherine J., Church, W. Bret, Cooper, Adam (R19184), Dong, Qihan, Fatima, Shadma (R20516), Graham, Garry G., Harman, David G. (R17307), Kanapaddala Gamage, Kasuni K. (S36864), Kim, Ryung R., Mann, Timothy J. (S33439), Razdan, Anshuli (S32879), Roohullah, Aflah (R19786), Russell, Pamela J., Sajinovic, Mila, Scott, Kieran F. (R17391), Souza, Paul de (R16678), Vafaee, Fatemeh   +16 more
core   +1 more source

Priority Actions and Progress to Substantially and Sustainably Reduce the Mortality, Morbidity and Socioeconomic Burden of Tropical Snakebite [PDF]

, 2016
The deliberations and conclusions of a Hinxton Retreat convened in September 2015, entitled “Mechanisms to reverse the public health neglect of snakebite victims” are reported.
Gutiérrez, José María, Harrison, Robert   +1 more
core   +2 more sources

Peripheral Arterial Thrombosis following Russell's Viper Bites

TH Open, 2023
Envenomings by Russell's viper (Daboia russelii), a species of high medical importance in India and other Asian countries, commonly result in hemorrhage, coagulopathies, necrosis, and acute kidney injury.
Subramanian Senthilkumaran, Ketan Patel, Elanchezhian Rajan, Pradeep Vijayakumar, Stephen W. Miller, Alexandra Rucavado, Soheil Gilabadi, Medha Sonavane, Nicholas J. Richards, Jarred Williams, Harry F. Williams, Steven A. Trim, Ponniah Thirumalaikolundusubramanian, José María Gutiérrez, Sakthivel Vaiyapuri   +14 more
doaj   +1 more source

Diagnostic and Antivenom Immunotherapeutic Approaches in the Management of Snakebites [PDF]

, 2023
Snakebite envenoming normally occurs as a result of the injection of venom following the bite of a venomous snake or the spraying of venom into a person’s eyes by snake species that are capable of spitting venom as a defense mechanism. According to World
Gikunju, Joseph K., Kyama, Mutinda Cleophas, Manson, Ernest Ziem   +2 more
core   +2 more sources

Effects of Varespladib Methyl on Biomarkers and Major Cardiovascular Events in Acute Coronary Syndrome Patients

Journal of the American College of Cardiology, 2010
The purpose of this study was to investigate the effects of varespladib on cardiovascular biomarkers in acute coronary syndrome patients.Secretory phospholipase A(2) (sPLA(2)) represents a family of proatherogenic enzymes that hydrolyze lipoprotein phospholipids, increasing their affinity for intimal proteoglycans; contribute to cholesterol loading of ...
Rosenson, Robert S., Hislop, Colin, Elliott, Michael, Stasiv, Yuri, Goulder, Michael, Waters, David   +5 more
openaire   +3 more sources

Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite

Journal of Tropical Medicine, Volume 2018, Issue 1, 2018., 2018
The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major therapeutic challenge.
Tommaso C. Bulfone, Stephen P. Samuel, Philip E. Bickler, Matthew R. Lewin, Marcel Tanner   +4 more
wiley   +1 more source

The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]

, 2020
Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core   +1 more source

Snake Venom PLA2, a Promising Target for Broad‐Spectrum Antivenom Drug Development

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
Snakebite envenomation is a neglected global health problem, causing substantial mortality, disability, and psychological morbidity, especially in rural tropical and subtropical zones. Antivenin is currently the only specific medicine for envenomation. However, it is restricted by cold storage, snakebite diagnosis, and high price.
Huixiang Xiao, Hong Pan, Keren Liao, Mengxue Yang, Chunhong Huang, Ji-Fu Wei   +5 more
wiley   +1 more source