Results 71 to 80 of about 949 (170)

Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation

The FASEB Journal, Volume 29, Issue 11, Page 4568-4578, November 2015., 2015
ABSTRACT Eicosanoids are important vascular regulators, but the phospholipase A2 (PLA2) isoforms supporting their production within the cardiovascular system are not fully understood. To address this, we have studied platelets, endothelial cells, and leukocytes from 2 siblings with a homozygous loss‐of‐function mutation in group IVA cytosolic ...
Nicholas S. Kirkby, Daniel M. Reed, Matthew L. Edin, Francesca Rauzi, Stefania Mataragka, Ivana Vojnovic, David Bishop‐Bailey, Ginger L. Milne, Hilary Longhurst, Darryl C. Zeldin, Jane A. Mitchell, Timothy D. Warner   +11 more
wiley   +1 more source

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade [PDF]

, 2017
There is limited knowledge about the metabolic reprogramming induced by cancer therapies, and how this contributes to therapeutic resistance. Here we show that although inhibition of PI3K-AKT-mTOR signaling markedly decreased glycolysis and restrained
Amling, C, Cheng, L, Drake, J, Evans, M, Garg, D, Kolahi, K, Liu, J-J, Lue, H-W, Martinez-Acevedo, A, Nomura, D, O'Donnell, Valerie, Podolak, J, Rantala, J, Rao, S, Ritz, A, Thomas, G, Thornburg, K, Truillet, C, Tyner, J, Xue, C-H   +19 more
core   +1 more source

Interactions of small molecule inhibitors with secreted phospholipase A2: A review of the structural data

Chemical Biology &Drug Design, Volume 103, Issue 2, February 2024.
Due to their roles in inflammation, the sPLA2 enzymes are of much medicinal interest. sPLA2 inhibitors have been developed for the treatment of inflammatory and other conditions such as cardiovascular disease, arteriosclerosis and rheumatoid arthritis.
Chantalle Crous, Anél Petzer, Jacobus P. Petzer   +2 more
wiley   +1 more source

Evolving targets for lipid‐modifying therapy

EMBO Molecular Medicine, Volume 6, Issue 10, Page 1215-1230, October 2014., 2014
This review article summarizes existing and emerging therapeutic strategies to modify all types of lipoproteins, whose concentration and function are critical in the progression of atherosclerosis. Abstract The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes ...
Rose Q Do, Stephen J Nicholls, Gregory G Schwartz   +2 more
wiley   +1 more source

Diverse Functions of Secretory Phospholipases A2

Advances in Vascular Medicine, Volume 2014, Issue 1, 2014., 2014
Phospholipase A2 enzymes (PLA2s) catalyze the hydrolysis of glycerophospholipids at their sn‐2 position releasing free fatty acids and lysophospholipids. Mammalian PLA2s are classified into several categories of which important groups include secreted PLA2s (sPLA2s) and cytosolic PLA2s (cPLA2s) that are calcium‐dependent for their catalytic activity ...
Preetha Shridas, Nancy R. Webb, David Tanne   +2 more
wiley   +1 more source

In Silico Evaluation of Quercetin Methylated Derivatives on the Interaction with Secretory Phospholipases A2 from Crotalus durissus terrificus and Bothrops jararacussu

Pharmaceuticals, 2023
Quercetin derivatives have already shown their anti-inflammatory potential, inhibiting essential enzymes involved in this process. Among diverse pro-inflammatory toxins from snake venoms, phospholipase A2 is one of the most abundant in some species, such
Mariana Novo Belchor, Caroline Ramos da Cruz Costa, Airam Roggero, Laila L. F. Moraes, Ricardo Samelo, Isabelly Annunciato, Marcos Antonio de Oliveira, Sergio F. Sousa, Marcos Hikari Toyama   +8 more
doaj   +1 more source

The (G>A) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population: The Genetics of Atherosclerotic Disease Mexican Study

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Coronary artery disease (CAD) is a multifactorial disorder that results from an excessive inflammatory response. Secretory phospholipase A2‐V (sPLA2‐V) encoded by PLA2G5 gene promotes diverse proinflammatory processes. The aim of the present study was to analyze if PLA2G5 gene polymorphisms are associated with premature CAD. Three PLA2G5 polymorphisms (
Gilberto Vargas-Alarcón, Carlos Posadas-Romero, Teresa Villarreal-Molina, Edith Alvarez-León, Javier Angeles-Martinez, María Elena Soto, Irma Monroy-Muñoz, Juan Gabriel Juárez, Carlos Jerges Sánchez-Ramírez, Julian Ramirez-Bello, Silvestre Ramírez-Fuentes, José Manuel Fragoso, José Manuel Rodríguez-Pérez, Terry K. Smith   +13 more
wiley   +1 more source

Pharmacological Characterisation of Pseudocerastes and Eristicophis Viper Venoms Reveal Anticancer (Melanoma) Properties and a Potentially Novel Mode of Fibrinogenolysis [PDF]

, 2021
Venoms are a rich source of potential lead compounds for drug discovery, and descriptive studies of venom form the first phase of the biodiscovery process.
Ali, Syed Abid, Bos, Mettine H.A., Casewell, Nicholas, Fathinia, Behzad, Fry, Bryan G., Ghezellou, Parviz, Ikonomopoulou, Maria P., op den Brouw, Bianca   +7 more
core   +2 more sources

Association between serum secretory phospholipase A2 and risk of ischemic stroke. [PDF]

, 2021
BACKGROUND AND PURPOSE: Previous literature has demonstrated an association between high serum levels of type-II secretory phospholipase A2 (sPLA2) concentration and an increased risk of coronary artery disease.
Mamas
core   +1 more source

Metabolomic Characterization of Human Model of Liver Rejection Identifies Aberrancies Linked to Cyclooxygenase (COX) and Nitric Oxide Synthase (NOS) [PDF]

, 2019
BACKGROUND Acute liver rejection (ALR), a significant complication of liver transplantation, burdens patients, healthcare payers, and the healthcare providers due to an increase in morbidity, cost, and resources.
Bettcher, Lisa, Ceballos, Brian, Ekser, Burcin, Ellensberg, Matthew, Elliott, Campbell M., Kubal, Chandrashekhar A., Maluccio, Mary A., Mangus, Richard S., Pepin, Robert, Raftery, Daniel, Saxena, Romil, Skill, Nicholas J.   +11 more
core   +1 more source