Results 71 to 80 of about 3,198,668 (318)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The Journal of Engineering, 2015 In this study, uncertainty and disturbance compensations are addressed for non-linear systems by an integral sliding mode (ISM) design. It is divided into two steps for implementation of the ISM control.
Xiaoyu Zhang
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Continuous finite-time TSM control for electronic throttle system
The Journal of Engineering, 2019 This article examines the position tracking difficulties of the electronic throttle (ET) system and presents a continuous finite-time terminal sliding mode (TSM) control method.
Oluwatoyin Timothy Agbaje +3 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Modeling dynamic systems of variable structure [PDF]
, 1984 Reliable software tools for mathematical modeling have been developed for simulation models but for constrained optimization models progress has been slower. The following approach examines the possibility of working with large-scale mathematical models in a compact form permitting the direct analysis of input-output relations where information is ...
openaire +3 more sources
The Journal of Engineering, 2019 To minimise the torque ripple for vector control of interior permanent magnet synchronous motor (IPMSM) of railway traction system, this study proposes a new velocity, torque and current three-loop control system, and designs a velocity and torque ...
Kaihui Zhao +6 more
doaj +1 more source
Duality Theory for Variable Costs in Joint Production [PDF]
Duality methods for incomplete systems of consumer demand equations are adapted to the dual structure of variable cost functions in joint production. This allows the identification of necessary and sufficient restrictions on technology and cost so that ...
Jeffrey LaFrance, Rulon Pope
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Machine learning–based robust trajectory tracking control for FSGR
The Journal of Engineering, 2019 Here, a robust adaptive trajectory tracking algorithm is proposed for free-form surface grinding robot (FSGR) in metal surface production line. Machine-learning method is used for robot dynamic approximation which is hard to obtain directly. Adaptive law
Lin Jia +5 more
doaj +1 more source