Results 261 to 270 of about 113,459 (293)

Rapid evolution of genes coding for variant surface glycoproteins in trypanosomes

Gene, 1982
We have used cloned DNA complementary to the messenger RNAs (mRNAs) for different variant surface glycoproteins (VSGs) of Trypanosoma brucei, stock 427, to study the degree of conservation of the corresponding nuclear genes in related trypanosome stocks.
A C, Frasch, P, Borst, J, Van den Burg
openaire   +2 more sources

Degradation, Recycling, and Shedding of Trypanosoma brucei Variant Surface Glycoprotein

The Journal of Protozoology, 1990
ABSTRACT. Trypanosoma brucei bloodstream forms express a densely packed surface coat consisting of identical variant surface glycoprotein (VSG) molecules. This surface coat is subject to antigenic variation by sequential expression of different VSG genes and thus enables the cells to escape the mammalian host's specific immune response.
A, Seyfang, D, Mecke, M, Duszenko
openaire   +2 more sources

A structural motif in the variant surface glycoproteins of Trypanosoma brucei

Nature, 1993
The variable domain of the trypanosome variant surface glycoprotein (VSG) ILTat 1.24 has been shown by X-ray crystallography to resemble closely the structures of VSG MITat 1.2, despite their low sequence similarity. Specific structural features of these VSGs, including substitution of carbohydrate for an alpha-helix, can be found in other VSG ...
M L, Blum, J A, Down, A M, Gurnett, M, Carrington, M J, Turner, D C, Wiley   +5 more
openaire   +2 more sources

Trypanosoma cruzi:Monoclonal Antibodies to the Surface Glycoprotein Superfamily Differentiate Subsets of the 85-kDa Surface Glycoproteins and Confirm Simultaneous Expression of Variant 85-kDa Surface Glycoproteins

Experimental Parasitology, 1999
Most surface glycoproteins expressed by mammalian-stage forms of Trypanosoma cruzi are homologous to the parasite's trans-sialidase and therefore are members of the parasite's trans-sialidase superfamily. Few members of this superfamily have trans-sialidase activity. The SA85-1 family is a subfamily of the trans-sialidase superfamily whose members lack
S J, Kahn, D, Nguyen, J, Norsen, M, Wleklinski, T, Granston, M, Kahn   +5 more
openaire   +2 more sources

Trypanosoma brucei: Conserved sequence organization 3′ to telomeric variant surface glycoprotein genes

Experimental Parasitology, 1989
We have previously postulated that telomeric variant surface glycoprotein (VSG) genes in Trypanosoma brucei serve more frequently than intrachromosomal VSG genes as basic copies for gene conversion. To examine this further we determined the sequence for approximately 1200 nucleotides 3' to the telomeric IsTat 1 VSG gene, expressed in early variant ...
R F, Aline, K, Stuart
openaire   +2 more sources

Endocytosis and intracellular occurrence of the variant surface glycoprotein in Trypanosoma congolense

Journal of Ultrastructure and Molecular Structure Research, 1988
Trypanosoma congolense bloodstream forms were examined for binding sites of polyclonal anti-variant surface glycoprotein (VSG) antibodies using immunoelectron microscopy. Besides the surface, the antibodies labeled intracellular vesicles, the tubular membrane system, secondary lysosomes, and the digestive vacuole. Protein A gold (PAG), peroxidase gold (
U, Frevert, E, Reinwald
openaire   +2 more sources

Variant-surface-glycoprotein phospholipase C

1998
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Regulation of variant surface glycoprotein synthesis in Trypanosoma brucei

Biochemical Society Transactions, 1988
J, Czichos, B, Ehlers, P, Overath
openaire   +2 more sources

Trypanosoma congolense: Surface glycoproteins of two early bloodstream variants

Experimental Parasitology, 1981
Neal L. Rosen, Masahiko Onodera, Peter J. Hotez, Mary S. Bogucki, Brian Elce, Curtis Patton, W.H. Konigsberg, G.A.M. Cross, Frank F. Richards   +8 more
openaire   +2 more sources

Variant Surface Glycoprotein

2006
openaire   +1 more source