The Origin of the Variola Virus [PDF]
Viruses, 2015 The question of the origin of smallpox, one of the major menaces to humankind, is a constant concern for the scientific community. Smallpox is caused by the agent referred to as the variola virus (VARV), which belongs to the genus Orthopoxvirus.
Igor V. Babkin, Irina N. Babkina
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Research with variola virus after smallpox eradication: Development of a mouse model for variola virus infection. [PDF]
PLoS Pathogens, 2021 Funder: Wellcome ...
Bernard Moss, Geoffrey L Smith
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Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines [PDF]
mBio, 2023 Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used to produce vaccines before then.
Aline R. V. Souza +4 more
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Prediction of steps in the evolution of variola virus host range. [PDF]
PLoS ONE, 2014 Variola virus, the agent of smallpox, has a severely restricted host range (humans) but a devastatingly high mortality rate. Although smallpox has been eradicated by a World Health Organization vaccination program, knowledge of the evolutionary processes
Chad Smithson +3 more
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ESR and NMR studies provide evidence that phosphatidyl glycerol specifically interacts with poxvirus membranes [PDF]
Virology Journal, 2010 Background The lung would be the first organ targeted in case of the use of Variola virus (the causative agent of smallpox) as a bioweapon. Pulmonary surfactant composed of lipids (90%) and proteins (10%) is considered the major physiological barrier ...
Perino Julien +3 more
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Evidence of Long-Distance Aerial Convection of Variola Virus and Implications for Disease Control [PDF]
Viruses, 2019 Two distinct phenomena of airborne transmission of variola virus (smallpox) were described in the pre-eradication era—direct respiratory transmission, and a unique phenomenon of transmission over greater distances, referred to as “aerial ...
Chandini Raina MacIntyre +4 more
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Re-Assembly and Analysis of an Ancient Variola Virus Genome [PDF]
Viruses, 2017 We report a major improvement to the assembly of published short read sequencing data from an ancient variola virus (VARV) genome by the removal of contig-capping sequencing tags and manual searches for gap-spanning reads. The new assembly, together with
Chad Smithson, Jacob Imbery, Chris Upton
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A Multiplex PCR/LDR Assay for the Simultaneous Identification of Category A Infectious Pathogens: Agents of Viral Hemorrhagic Fever and Variola Virus. [PDF]
PLoS ONE, 2015 CDC designated category A infectious agents pose a major risk to national security and require special action for public health preparedness. They include viruses that cause viral hemorrhagic fever (VHF) syndrome as well as variola virus, the agent of ...
Sanchita Das +12 more
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EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses [PDF]
Journal of Immunology Research, 2015 Concerns that variola viruses might be used as bioweapons have renewed the interest in developing new and safer smallpox vaccines. Variola virus genomes are now widely available, allowing computational characterization of the entire T-cell epitome and ...
Magdalena Molero-Abraham +4 more
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Neutralization Determinants on Poxviruses
Viruses, 2023 Smallpox was a highly contagious disease caused by the variola virus. The disease affected millions of people over thousands of years and variola virus ranked as one of the deadliest viruses in human history. The complete eradication of smallpox in 1980,
Vernuccio Riccardo, Guardado-Calvo Pablo
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