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Phylogeographical and evolutionary history of variola major virus; a question of timescales?

open access: yesLe infezioni in medicina, 2020
Aim of this study was to reconstruct the phylogeography of variola virus (VARV) in the XX century, using 47 VARV whole genome sequences available in public databases, through two different methods for ancestral character reconstruction: a frequently used
A. Bergna   +6 more
semanticscholar   +1 more source

Diagnóstico laboratorial da varíola: I. resultados do primeiro ano de atividade

open access: yesRevista da Sociedade Brasileira de Medicina Tropical, 1970
Os autores escrevem a experiência obtida no Diagnóstico Laboratorial de Varíola, durante o primeiro ano de funcionamento de uma unidade montada para servir à Campanha de Erradicação de Varíola no Brasil.
H. G. Schatzmayr, J. A. Mesquita
doaj   +1 more source

Antiviral Activity of Extracts from Basidiomycetes for Orthopoxviruses

open access: yesПроблемы особо опасных инфекций, 2012
Carried out was evaluation of the effect of water extracts from basidiomycetes in Vero cell culture on variola virus, and vaccinia virus. Antiviral effect demonstrated Inonotus obliquus (Chaga), befungin and melanin from chaga,
T. V. Teplyakova   +8 more
doaj   +1 more source

The Mpox, serious menace, or paper tiger?

open access: yesIranian Journal of Microbiology, 2022
One of the most horrible diseases in history, Smallpox is caused by the Variola from Poxvirus family, has caused great morbidity and mortality along the way since it was eradicated in the 20th century.
Shahram Jalilian, Mohammad-Navid Bastani
doaj   +1 more source

Potential Viroporin Candidates From Pathogenic Viruses Using Bacteria-Based Bioassays

open access: yesViruses, 2019
Viroporins are a family of small hydrophobic proteins found in many enveloped viruses that are capable of ion transport. Building upon the ability to inhibit influenza by blocking its archetypical M2 H+ channel, as a family, viroporins may represent a ...
Prabhat Pratap Singh Tomar   +3 more
doaj   +1 more source

Diagnóstico laboratorial de varíola: II. resultados do segundo ano de atividades, de maio de 1969 a maio de 1970

open access: yesRevista da Sociedade Brasileira de Medicina Tropical, 1970
Os autores relatam os resultados obtidos no diagnóstico laboratorial de varíola, durante o segundo ano de funcionamento de uma unidade montada no Instituto Presidente Castello Branco, da Fundação Instituto Oswaldo Crus, no Rio de Janeiro.
H. G. Schatzinayr, J. A. Mesquita
doaj   +1 more source

Designing a smallpox B-cell and T-cell multi-epitope subunit vaccine using a comprehensive immunoinformatics approach

open access: yesMicrobiology Spectrum
Smallpox is a highly contagious human disease caused by the variola virus. Although the disease was eliminated in 1979 due to its highly contagious nature and historical pathogenicity, with a mortality rate of up to 30%, this virus is an important ...
Changqing Yu   +7 more
doaj   +1 more source

In vitro inhibition of monkeypox virus production and spread by Interferon-β

open access: yesVirology Journal, 2012
Background The Orthopoxvirus genus contains numerous virus species that are capable of causing disease in humans, including variola virus (the etiological agent of smallpox), monkeypox virus, cowpox virus, and vaccinia virus (the prototypical member of ...
Johnston Sara C   +5 more
doaj   +1 more source

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

open access: yesAdvanced Science, EarlyView.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang   +16 more
wiley   +1 more source

Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

open access: yesViruses, 2021
Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial ...
Reed F. Johnson   +19 more
doaj   +1 more source

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