Results 1 to 10 of about 11,287 (155)
Research with variola virus after smallpox eradication: Development of a mouse model for variola virus infection. [PDF]
PLoS Pathog, 2021 In this issue of PLOS Pathogens, Hutson and coworkers at the Centers for Disease Control and Prevention (CDC) in Atlanta, USA describe a study with infectious variola virus that was approved by the World Health Organization (WHO) Advisory Committee on ...
Moss B, Smith GL.
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The origin of the variola virus. [PDF]
Viruses, 2015 The question of the origin of smallpox, one of the major menaces to humankind, is a constant concern for the scientific community. Smallpox is caused by the agent referred to as the variola virus (VARV), which belongs to the genus Orthopoxvirus. In the last century, smallpox was declared eradicated from the human community; however, the mechanisms ...
Babkin IV, Babkina IN.
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Variola virus in a 300-year-old Siberian mummy. [PDF]
New England Journal of Medicine, 2012 International audienceNo abstract ...
Alekseev, Anatoly N +14 more
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Prediction of steps in the evolution of variola virus host range. [PDF]
PLoS One, 2014 Variola virus, the agent of smallpox, has a severely restricted host range (humans) but a devastatingly high mortality rate. Although smallpox has been eradicated by a World Health Organization vaccination program, knowledge of the evolutionary processes by which human super-pathogens such as variola virus arise is important. By analyzing the evolution
Smithson C +3 more
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In vitro efficacy of brincidofovir against variola virus. [PDF]
Antimicrob Agents Chemother, 2014 ABSTRACT Brincidofovir (CMX001), a lipid conjugate of the acyclic nucleotide phosphonate cidofovir, is under development for smallpox treatment using “the Animal Rule,” established by the FDA in 2002. Brincidofovir reduces mortality caused by orthopoxvirus infection in animal models.
Olson VA +7 more
europepmc +4 more sources
Identification of SNPs associated with variola virus virulence. [PDF]
BioData Min, 2013 Abstract Background Decades after the eradication of smallpox, its etiological agent, variola virus (VARV), remains a threat as a potential bioweapon. Outbreaks of smallpox around the time of the global eradication effort exhibited variable case fatality rates (CFRs), likely attributable in part to complex viral ...
Hoen AG, Gardner SN, Moore JH.
europepmc +5 more sources
Re-Assembly and Analysis of an Ancient Variola Virus Genome. [PDF]
Viruses, 2017 We report a major improvement to the assembly of published short read sequencing data from an ancient variola virus (VARV) genome by the removal of contig-capping sequencing tags and manual searches for gap-spanning reads. The new assembly, together with camelpox and taterapox genomes, permitted new dates to be calculated for the last common ancestor ...
Smithson C, Imbery J, Upton C.
europepmc +6 more sources
Efficacy of heat against the vaccinia virus, variola virus and monkeypox virus. [PDF]
J Hosp Infect, 2022 Kampf G.
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SUSCEPTIBILITY OF SUCKLING MICE TO VARIOLA VIRUS [PDF]
Journal of Bacteriology, 1961 Marshall, Ronald G. (Army Chemical Corps, Fredrick, Md.), and Peter J. Gerone . Susceptibility of suckling mice to variola virus. J. Bacteriol. 82: 15–19. 1961.—The susceptibility of suckling mice inoculated intraperitoneally or intracerebrally with variola virus was investigated.
Peter J. Gerone, Ronald G. Marshall
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Immunofluorescence staining for detection of variola virus [PDF]
Journal of Clinical Microbiology, 1981 In September 1975 Bangladesh was the only country in the world with endemic variola major, and the eradication of the disease was imminent. A rapid and accurate laboratory diagnostic method was required to supplement immunodiffusion in agar gel and culture on chorioallantoic membrane of embryonated egg available at the Institute of Public Health in ...
Stanley O. Foster +3 more
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