Results 91 to 100 of about 1,665,482 (247)

Lipid nanoparticle delivery of unmodified mRNAs encoding multiple monoclonal antibodies targeting poxviruses in rabbits

open access: yesMolecular Therapy: Nucleic Acids, 2022
Poxviruses are a large and complex family of viruses with members such as monkeypox virus and variola virus. The possibility of an outbreak of monkeypox virus (or a related poxvirus) or the misuse of variola virus justifies the development of ...
Eric M. Mucker   +3 more
doaj  

Ectromelia Virus Infections of Mice as a Model to Support the Licensure of Anti-Orthopoxvirus Therapeutics

open access: yesViruses, 2010
The absence of herd immunity to orthopoxviruses and the concern that variola or monkeypox viruses could be used for bioterroristic activities has stimulated the development of therapeutics and safer prophylactics.
R. Mark Buller   +4 more
doaj   +1 more source

Fatal Cowpox Virus Infection in Human Fetus, France, 2017

open access: yesEmerging Infectious Diseases, 2021
Cowpox virus (CPXV) has an animal reservoir and is typically transmitted to humans by contact with infected animals. In 2017, CPXV infection of a pregnant woman in France led to the death of her fetus.
Audrey Ferrier   +10 more
doaj   +1 more source

Monkeypox virus emerges from the shadow of its more infamous cousin: family biology matters

open access: yesEmerging Microbes and Infections, 2022
Monkeypox virus (MPXV) is closely related to the infamous variola (smallpox) virus, causing a febrile rash illness in humans similar to but milder than smallpox.
Y. Xiang, A. White
semanticscholar   +1 more source

Biological Terrorism [PDF]

open access: yes, 2008
In the aftermath of the September 11, 2001 attacks and the subsequent mail-borne anthrax attack of October 2001, it has become dear that health care providers may be called upon to respond to victims of terrorism. Biological terrorism (BT), in particular,
Centers for Disease Control and Prevention   +4 more
core   +2 more sources

Clinical Manifestations in 32 Cases of Mpox Infection: A Retrospective Study in a Single Dermatology Clinic in Japan

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Mpox, a zoonotic orthopox virus, has re‐emerged globally since May 2022. In Tokyo, 168 cases were reported in 2023. About 20% were diagnosed in our department. In this study, we analyzed the clinical and epidemiological characteristics of 32 mpox patients diagnosed in our department in 2023.
Amika Nakazawa   +5 more
wiley   +1 more source

Expression and functional characterisation of Variola and Monkeypox virus tumour necrosis factor receptor (TNFR) proteins [PDF]

open access: yes, 2012
University of Technology, Sydney. Faculty of Science.Tumour necrosis factor-a (TNFα) is a pleiotropic cytokine that plays a critical role in cellular response to virus infection. Virtually all poxviruses encode genes that are homologous to human tumour
Sherwood, S
core  

Dangerous Liaisons: Unveiling the Co‐Constitution of Emerging Infectious Diseases and Industrial Meat Production

open access: yesAntipode, EarlyView.
Abstract Outbreaks of highly pathogenic avian influenza (HPAI) have intensified over the last decade, spotlighting the concept of “epicentre” as a means of locating disease origins. Although epicentre thinking can facilitate rapid interventions, it often overlooks the political‐economic and ecological forces driving outbreaks.
Mariel Aguilar‐Støen   +4 more
wiley   +1 more source

Strategies for the Modification of Vaccinia Virus towards a Better Vaccine Vector

open access: yesZoonoses
Vaccinia virus (VACV) confers cross-protective immunity against variola virus, the causative agent of smallpox, and has therefore been extensively exploited as a preventive vaccine.
Hao Sun, Xinwen Chen, Yun Wang
doaj   +1 more source

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity [PDF]

open access: yes, 2013
Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity.
Benfield, C T O   +6 more
core   +1 more source

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