Re-Assembly and Analysis of an Ancient Variola Virus Genome [PDF]
Viruses, 2017 We report a major improvement to the assembly of published short read sequencing data from an ancient variola virus (VARV) genome by the removal of contig-capping sequencing tags and manual searches for gap-spanning reads. The new assembly, together with
Chad Smithson, Jacob Imbery, Chris Upton
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The Origin of the Variola Virus [PDF]
Viruses, 2015 The question of the origin of smallpox, one of the major menaces to humankind, is a constant concern for the scientific community. Smallpox is caused by the agent referred to as the variola virus (VARV), which belongs to the genus Orthopoxvirus.
Igor V. Babkin, Irina N. Babkina
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Prediction of steps in the evolution of variola virus host range. [PDF]
PLoS ONE, 2014 Variola virus, the agent of smallpox, has a severely restricted host range (humans) but a devastatingly high mortality rate. Although smallpox has been eradicated by a World Health Organization vaccination program, knowledge of the evolutionary processes
Chad Smithson +3 more
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Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines [PDF]
mBio, 2023 Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used to produce vaccines before then.
Aline R. V. Souza +4 more
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In vitro efficacy of brincidofovir against variola virus. [PDF]
Antimicrob Agents Chemother, 2014 ABSTRACT Brincidofovir (CMX001), a lipid conjugate of the acyclic nucleotide phosphonate cidofovir, is under development for smallpox treatment using “the Animal Rule,” established by the FDA in 2002. Brincidofovir reduces mortality caused by orthopoxvirus infection in animal models.
Olson VA +7 more
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Evidence of Long-Distance Aerial Convection of Variola Virus and Implications for Disease Control [PDF]
Viruses, 2019 Two distinct phenomena of airborne transmission of variola virus (smallpox) were described in the pre-eradication era—direct respiratory transmission, and a unique phenomenon of transmission over greater distances, referred to as “aerial ...
Chandini Raina MacIntyre +4 more
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Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox: part II. [PDF]
J Biomol Struct Dyn, 2019 Acknowledging the importance of studies toward the development of measures against terrorism and bioterrorism, this study aims to contribute to the design of new prototypes of potential drugs against smallpox.
Rodrigues Garcia D +5 more
europepmc +4 more sources
Research with variola virus after smallpox eradication: Development of a mouse model for variola virus infection. [PDF]
PLoS Pathogens, 2021 Funder: Wellcome ...
Bernard Moss, Geoffrey L Smith
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A Multiplex PCR/LDR Assay for the Simultaneous Identification of Category A Infectious Pathogens: Agents of Viral Hemorrhagic Fever and Variola Virus. [PDF]
PLoS ONE, 2015 CDC designated category A infectious agents pose a major risk to national security and require special action for public health preparedness. They include viruses that cause viral hemorrhagic fever (VHF) syndrome as well as variola virus, the agent of ...
Sanchita Das +12 more
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EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses [PDF]
Journal of Immunology Research, 2015 Concerns that variola viruses might be used as bioweapons have renewed the interest in developing new and safer smallpox vaccines. Variola virus genomes are now widely available, allowing computational characterization of the entire T-cell epitome and ...
Magdalena Molero-Abraham +4 more
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