Results 11 to 20 of about 12,414 (226)
In vitro efficacy of brincidofovir against variola virus. [PDF]
Antimicrob Agents Chemother, 2014 ABSTRACT Brincidofovir (CMX001), a lipid conjugate of the acyclic nucleotide phosphonate cidofovir, is under development for smallpox treatment using “the Animal Rule,” established by the FDA in 2002. Brincidofovir reduces mortality caused by orthopoxvirus infection in animal models.
Olson VA +7 more
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Variola virus in a 300-year-old Siberian mummy. [PDF]
New England Journal of Medicine, 2012 International audienceNo abstract ...
Alekseev, Anatoly N +14 more
core +6 more sources
THE STABILITY OF VARIOLA VIRUS PROPAGATED IN EMBRYONATED EGGS [PDF]
Journal of Experimental Medicine, 1943 After 24 transfers in embryonated eggs a strain of variola virus (Chinese) was established in the testis of the rabbit and maintained for 11 passages at intervals of 7 days. Residence in the rabbit testis was not accompanied by any significant alteration in the species identity of the virus.
John B. Nelson
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SUSCEPTIBILITY OF SUCKLING MICE TO VARIOLA VIRUS [PDF]
Journal of Bacteriology, 1961 Marshall, Ronald G. (Army Chemical Corps, Fredrick, Md.), and Peter J. Gerone . Susceptibility of suckling mice to variola virus. J. Bacteriol. 82: 15–19. 1961.—The susceptibility of suckling mice inoculated intraperitoneally or intracerebrally with variola virus was investigated.
Ronald G. Marshall, Peter J. Gerone
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Single-Dose Assay Technique for Variola Virus [PDF]
Applied Microbiology, 1964 A biological assay for variola virus was needed that would (i) require a minimum of time and (ii) have acceptable precision. Preliminary titrations made in 11-day-old embryonated eggs and in suckling mice (6 to 24 hr of age) demonstrated a linear relationship between the concentration of variola virus injected and the mean reciprocal time to death (MTD)
Jean M. Riley, Michael D. Orlando
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SURVIVAL OF VARIOLA VIRUS IN CHORIOALLANTOIC MEMBRANE PREPARATIONS [PDF]
Journal of Bacteriology, 1959 Nicholas Hahon
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Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox: part II. [PDF]
J Biomol Struct Dyn, 2019 Rodrigues Garcia D +5 more
europepmc +3 more sources
Flocculation Experiments with Variola and Vaccinia Virus [PDF]
American Journal of Public Health and the Nations Health, 1931 J MMUNOLOGICAL studies of viruses have shown clearly and uniLformly that virucidal properties are developed in the serum of animals following an attack of the disease and in some instances following injection of the killed virus. The demonstration of agglutinins, precipitins or complement-fixing antibodies has not been so convincing and, in contrast to
Leon C. Havens, Catherine R. Mayfield
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Should Remaining Stockpiles of Smallpox Virus (Variola) Be Destroyed?
Emerging Infectious Diseases, 2011 In 2011, the World Health Organization will recommend the fate of existing smallpox stockpiles, but circumstances have changed since the complete destruction of these cultures was first proposed.
Raymond S. Weinstein
doaj +4 more sources
Effect of disinfectants on variola virus in cell culture [PDF]
Applied and Environmental Microbiology, 1976 Twenty kinds of disinfectants were examined for ability to inactivate variola virus. Cytopathic effect and plaque formation on monolayer cultures of an established monkey kidney cell line were used as indicators of virus inactivation. A micromethod using microplate cultures, and not requiring a CO2 incubator, was adopted.
I Tanabe, S Hotta
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