Identification of SNPs associated with variola virus virulence. [PDF]
BioData Min, 2013 BackgroundDecades after the eradication of smallpox, its etiological agent, variola virus (VARV), remains a threat as a potential bioweapon. Outbreaks of smallpox around the time of the global eradication effort exhibited variable case fatality rates ...
Hoen AG, Gardner SN, Moore JH.
europepmc +6 more sources
Variola Virus and Clade I Mpox Virus Differentially Modulate Cellular Responses Longitudinally in Monocytes During Infection. [PDF]
J Infect Dis, 2023 Variola virus (VARV), the etiological agent of smallpox, had enormous impacts on global health prior to its eradication. In the absence of global vaccination programs, mpox virus (MPXV) has become a growing public health threat that includes endemic and ...
Wahl V +5 more
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Analysis of variola virus molecular evolution suggests an old origin of the virus consistent with historical records. [PDF]
Microb Genom, 2023 Archaeovirology efforts provided a rich portrait of the evolutionary history of variola virus (VARV, the cause of smallpox), which was characterized by lineage extinctions and a relatively recent origin of the virus as a human pathogen (~1700 years ago ...
Forni D +4 more
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Efficacy of heat against the vaccinia virus, variola virus and monkeypox virus. [PDF]
J Hosp Infect, 2022 Kampf G.
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In Silico Studies of Potential Selective Inhibitors of Thymidylate Kinase from Variola virus. [PDF]
Pharmaceuticals (Basel), 2021 Continuing the work developed by our research group, in the present manuscript, we performed a theoretical study of 10 new structures derived from the antivirals cidofovir and ribavirin, as inhibitor prototypes for the enzyme thymidylate kinase from ...
Garcia DR +7 more
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Teaching a new mouse old tricks: Humanized mice as an infection model for Variola virus. [PDF]
PLoS Pathog, 2021 Smallpox, caused by the solely human pathogen Variola virus (VARV), was declared eradicated in 1980. While known VARV stocks are secure, smallpox remains a bioterrorist threat agent. Recent U.S. Food and Drug Administration approval of the first smallpox
Hutson CL +13 more
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Variola virus genome sequenced from an eighteenth-century museum specimen supports the recent origin of smallpox. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2020 Smallpox, caused by the variola virus (VARV), was a highly virulent disease with high mortality rates causing a major threat for global human health until its successful eradication in 1980.
Ferrari G +8 more
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Are we there yet? The smallpox research agenda using variola virus. [PDF]
PLoS Pathog, 2014 Despite significant advances, there is more work to be done before the international community can be confident that it possesses sufficient protection against any future smallpox threats.
Damon IK, Damaso CR, McFadden G.
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HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus. [PDF]
Cell RepLu Y +6 more
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Use of live Variola virus to determine whether CAST/EiJ mice are a suitable surrogate animal model for human smallpox. [PDF]
Virus Res, 2020 Gallardo-Romero NF +9 more
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