THE STABILITY OF VARIOLA VIRUS PROPAGATED IN EMBRYONATED EGGS [PDF]
Journal of Experimental Medicine, 1943 After 24 transfers in embryonated eggs a strain of variola virus (Chinese) was established in the testis of the rabbit and maintained for 11 passages at intervals of 7 days. Residence in the rabbit testis was not accompanied by any significant alteration in the species identity of the virus.
John B. Nelson
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Assay of Variola Virus by the Fluorescent Cell-Counting Technique [PDF]
Applied Microbiology, 1965 A quantitative assay for infective variola virus particles was developed which is based on the enumeration of cells containing fluorescent viral antigen after infection of McCoy cell monolayers. The direct fluorescent-antibody technique was employed to stain cells.
Nicholas Hahon
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Analysis of variola virus molecular evolution suggests an old origin of the virus consistent with historical records. [PDF]
Microb Genom, 2023 Archaeovirology efforts provided a rich portrait of the evolutionary history of variola virus (VARV, the cause of smallpox), which was characterized by lineage extinctions and a relatively recent origin of the virus as a human pathogen (~1700 years ago ...
Forni D +4 more
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Use of the Aerosol Rabbitpox Virus Model for Evaluation of Anti-Poxvirus Agents [PDF]
Viruses, 2010 Smallpox is an acute disease caused by infection with variola virus that has had historic effects on the human population due to its virulence and infectivity.
Roy, Chad J., Voss, Thomas G.
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ESR and NMR studies provide evidence that phosphatidyl glycerol specifically interacts with poxvirus membranes [PDF]
Virology Journal, 2010 Background The lung would be the first organ targeted in case of the use of Variola virus (the causative agent of smallpox) as a bioweapon. Pulmonary surfactant composed of lipids (90%) and proteins (10%) is considered the major physiological
Crouzier, David +3 more
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In Silico Studies of Potential Selective Inhibitors of Thymidylate Kinase from Variola virus. [PDF]
Pharmaceuticals (Basel), 2021 Continuing the work developed by our research group, in the present manuscript, we performed a theoretical study of 10 new structures derived from the antivirals cidofovir and ribavirin, as inhibitor prototypes for the enzyme thymidylate kinase from ...
Garcia DR +7 more
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Teaching a new mouse old tricks: Humanized mice as an infection model for Variola virus. [PDF]
PLoS Pathog, 2021 Smallpox, caused by the solely human pathogen Variola virus (VARV), was declared eradicated in 1980. While known VARV stocks are secure, smallpox remains a bioterrorist threat agent. Recent U.S. Food and Drug Administration approval of the first smallpox
Hutson CL +13 more
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Progression of Pathogenic Events in Cynomolgus Macaques Infected with Variola Virus
PLoS ONE, 2011 Smallpox, caused by variola virus (VARV), is a devastating human disease that affected millions worldwide until the virus was eradicated in the 1970 s.
Victoria Wahl‐Jensen +10 more
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Variola virus genome sequenced from an eighteenth-century museum specimen supports the recent origin of smallpox. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2020 Smallpox, caused by the variola virus (VARV), was a highly virulent disease with high mortality rates causing a major threat for global human health until its successful eradication in 1980.
Ferrari G +8 more
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Immunological Memory after Exposure to Variola Virus, Monkeypox Virus, and Vaccinia Virus [PDF]
The Journal of Infectious Diseases, 2007 We compared cellular and humoral immunity to vaccinia virus (VV) in individuals exposed to 3 different orthopoxviruses: 154 individuals previously vaccinated with VV, 7 individuals with a history of monkeypox virus infection, and 8 individuals with a history of variola virus infection.
William Borkowsky +9 more
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