Results 41 to 50 of about 14,974 (222)

Designing a smallpox B-cell and T-cell multi-epitope subunit vaccine using a comprehensive immunoinformatics approach

Microbiology Spectrum
Smallpox is a highly contagious human disease caused by the variola virus. Although the disease was eliminated in 1979 due to its highly contagious nature and historical pathogenicity, with a mortality rate of up to 30%, this virus is an important ...
Changqing Yu, Qi Wu, Jiuqing Xin, Qiujuan Yu, Zhixin Ma, Mengzhou Xue, Qingyuan Xu, Chunfu Zheng   +7 more
doaj   +1 more source

Variola virus in a 300-year-old Siberian mummy. [PDF]

, 2012
International audienceNo abstract ...
Alekseev, Anatoly N, Balaresque, Patricia, Biagini, Philippe, Cannet, Catherine, Crubézy, Eric, De Micco, Philippe, Duchesne, Sylvie, Gerard, Patrice, Geraut, Annie, Keyser, Christine, Ludes, Bertrand, Nikolaeva, Dariya, Orlando, Ludovic, Thèves, Catherine, Willerslev, Eske   +14 more
core   +3 more sources

Smallpox, Monkeypox and Other Human Orthopoxvirus Infections

Viruses, 2022
Considering that vaccination against smallpox with live vaccinia virus led to serious adverse effects in some cases, the WHO, after declaration of the global eradication of smallpox in 1980, strongly recommended to discontinue the vaccination in all ...
Galina A. Shchelkunova, Sergei N. Shchelkunov   +1 more
doaj   +1 more source

Deliberate Extinction: Whether to Destroy the Last Smallpox Virus [PDF]

, 2004
The target problem to be examined is smallpox. Specifically, what should we (the United States and the entire world) now do with the last known residual samples of the virus that causes this uniquely horrific disease?
Koplow, David A.
core   +1 more source

Micro/nanorobots for detecting and eliminating biological and chemical warfare agents

BMEMat, EarlyView.
Fuel‐powered and field‐driven micro/nanorobots provide a cutting‐edge platform to safeguard national security and defense. This review reports the latest research progress in micro/nanorobots in sensing and detoxifying biological and chemical warfare agents.
Song Li, Huaijuan Zhou, Di Shi, Zdeněk Sofer, Jinhua Li   +4 more
wiley   +1 more source

Comparative biochemical and functional analysis of viral and human secreted tumor necrosis factor (TNF) decoy receptors [PDF]

, 2015
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. The blockade of tumor necrosis factor (TNF) by etanercept, a soluble version of the human TNF receptor 2 (hTNFR2), is a well established strategy to inhibit adverse TNF-mediated ...
Alcamí, Antonio, Alejo, Alí, Pontejo, Sergio M.   +2 more
core   +1 more source

Spherical Nucleic Acid Stabilized Cage Type Three‐Dimensional Electrochemiluminescence Probe for Sensitive and Amplification‐Free Diagnosis of Infectious Diseases

Exploration, EarlyView.
This work developed a spherical nucleic acid stabilized cage‐type 3D electrochemiluminescence reporter probe for amplification‐free and ultrasensitive detection of pathogenic. Furthermore, a hand‐held detection device was designed, and we established a straightforward workflow enabling sample to answer within 15 min.
Yu Fu, Wenlu Song, Jinyan Lin, Wei Wang, Lunjing Liu, Wenjie Wu, Huiyi Yang, Jingru Wang, Yang Yang, Bowen Shu, Yideng Jiang, Yuhui Liao   +11 more
wiley   +1 more source

In vitro inhibition of monkeypox virus production and spread by Interferon-β

Virology Journal, 2012
Background The Orthopoxvirus genus contains numerous virus species that are capable of causing disease in humans, including variola virus (the etiological agent of smallpox), monkeypox virus, cowpox virus, and vaccinia virus (the prototypical member of ...
Johnston Sara C, Lin Kenny L, Connor John H, Ruthel Gordon, Goff Arthur, Hensley Lisa E   +5 more
doaj   +1 more source

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward, Peters, Nicholas Edward   +1 more
core   +1 more source

Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods.

PLoS Pathogens
Smallpox was the most rampant infectious disease killer of the 20th century, yet much remains unknown about the pathogenesis of the variola virus.
Todd M Bell, Paul Facemire, Jeremy J Bearss, Jo Lynne Raymond, Jennifer Chapman, Xiankun Zeng, Joshua D Shamblin, Janice A Williams, Douglas W Grosenbach, Dennis E Hruby, Inger K Damon, Arthur J Goff, Eric M Mucker   +12 more
doaj   +1 more source