Results 41 to 50 of about 10,310 (196)

Designing a smallpox B-cell and T-cell multi-epitope subunit vaccine using a comprehensive immunoinformatics approach

Microbiology Spectrum
Smallpox is a highly contagious human disease caused by the variola virus. Although the disease was eliminated in 1979 due to its highly contagious nature and historical pathogenicity, with a mortality rate of up to 30%, this virus is an important ...
Changqing Yu, Qi Wu, Jiuqing Xin, Qiujuan Yu, Zhixin Ma, Mengzhou Xue, Qingyuan Xu, Chunfu Zheng   +7 more
doaj   +1 more source

In vitro inhibition of monkeypox virus production and spread by Interferon-β

Virology Journal, 2012
Background The Orthopoxvirus genus contains numerous virus species that are capable of causing disease in humans, including variola virus (the etiological agent of smallpox), monkeypox virus, cowpox virus, and vaccinia virus (the prototypical member of ...
Johnston Sara C, Lin Kenny L, Connor John H, Ruthel Gordon, Goff Arthur, Hensley Lisa E   +5 more
doaj   +1 more source

Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

Viruses, 2021
Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial ...
Reed F. Johnson, Lauren A. Keith, Timothy K. Cooper, Srikanth Yellayi, Nicole M. Josleyn, Krisztina B. Janosko, James D. Pettitt, David Thomasson, Katie R. Hagen, Robin Gross, John G. Bernbaum, Debbie Douglas, Jeffrey Solomon, Mark Martinez, Kurt Cooper, Marisa St. Claire, Danny R. Ragland, Peter B. Jahrling, Jens H. Kuhn, Andrew E. Arai   +19 more
doaj   +1 more source

Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods.

PLoS Pathogens
Smallpox was the most rampant infectious disease killer of the 20th century, yet much remains unknown about the pathogenesis of the variola virus.
Todd M Bell, Paul Facemire, Jeremy J Bearss, Jo Lynne Raymond, Jennifer Chapman, Xiankun Zeng, Joshua D Shamblin, Janice A Williams, Douglas W Grosenbach, Dennis E Hruby, Inger K Damon, Arthur J Goff, Eric M Mucker   +12 more
doaj   +1 more source

Una nueva alerta mundial en salud causada por la viruela del simio

Interdisciplinary Journal of Epidemiology and Public Health, 2022
Introducción: La viruela del simio es una zoonosis de etiología viral causada por virus de la viruela del simio. Es una enfermedad endémica en los países africanos.
Richar Jose Gomez de la Rosa, Juan Pablo Rojas Hernandez   +1 more
doaj   +1 more source

Biological warfare: The many possibilities

South African Family Practice, 2004
Biological warfare has been a threat to society for many decades. This article summarises some of the most likely organisms suitable for a bio-terrorist attack, including Bacillus anthracis, Francisella tularensis, Yersinia pestis, the agents of viral ...
E. Wasserman
doaj   +1 more source

In vitro characterization of a nineteenth-century therapy for smallpox. [PDF]

PLoS ONE, 2012
In the nineteenth century, smallpox ravaged through the United States and Canada. At this time, a botanical preparation, derived from the carnivorous plant Sarracenia purpurea, was proclaimed as being a successful therapy for smallpox infections.
William Arndt, Chandra Mitnik, Karen L Denzler, Stacy White, Robert Waters, Bertram L Jacobs, Yvan Rochon, Victoria A Olson, Inger K Damon, Jeffrey O Langland   +9 more
doaj   +1 more source

Smallpox, Monkeypox and Other Human Orthopoxvirus Infections

Viruses, 2022
Considering that vaccination against smallpox with live vaccinia virus led to serious adverse effects in some cases, the WHO, after declaration of the global eradication of smallpox in 1980, strongly recommended to discontinue the vaccination in all ...
Galina A. Shchelkunova, Sergei N. Shchelkunov   +1 more
doaj   +1 more source

Are We Prepared in Case of a Possible Smallpox-Like Disease Emergence?

Viruses, 2017
Smallpox was the first human disease to be eradicated, through a concerted vaccination campaign led by the World Health Organization. Since its eradication, routine vaccination against smallpox has ceased, leaving the world population susceptible to ...
Victoria A. Olson, Sergei N. Shchelkunov
doaj   +1 more source

An APOBEC3 Mutational Signature in the Genomes of Human-Infecting Orthopoxviruses

mSphere, 2023
The ongoing worldwide monkeypox outbreak is caused by viral lineages (globally referred to as hMPXV1) that are related to but distinct from clade IIb MPXV viruses transmitted within Nigeria.
Diego Forni, Rachele Cagliani, Uberto Pozzoli, Manuela Sironi   +3 more
doaj   +1 more source