Results 51 to 60 of about 14,974 (222)

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. [PDF]

, 2009
Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution
Dever, Thomas E, Dittmar, Katharina, Gibbs, James S, Rothenburg, Stefan, Seo, Eun Joo   +4 more
core  

Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

Viruses, 2021
Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial ...
Reed F. Johnson, Lauren A. Keith, Timothy K. Cooper, Srikanth Yellayi, Nicole M. Josleyn, Krisztina B. Janosko, James D. Pettitt, David Thomasson, Katie R. Hagen, Robin Gross, John G. Bernbaum, Debbie Douglas, Jeffrey Solomon, Mark Martinez, Kurt Cooper, Marisa St. Claire, Danny R. Ragland, Peter B. Jahrling, Jens H. Kuhn, Andrew E. Arai   +19 more
doaj   +1 more source

Immunogenicity of HLA Class i and II double restricted influenza a-derived peptides [PDF]

, 2016
The aim of the present study was to identify influenza A-derived peptides which bind to both HLA class I and-II molecules and by immunization lead to both HLA class I and class II restricted immune responses.
Buus, Søren, Christensen, Jan Pravsgaard, Claesson, Mogens Helweg, Korsholm, Karen Smith, Nielsen, Morten, Pedersen, Sara Ram, Rasmussen, Michael   +6 more
core   +6 more sources

Vaccinations During Pregnancy Protect the Mother–Infant Dyad and Are Generally Safe

Acta Paediatrica, EarlyView.
ABSTRACT Aim Vaccination in pregnancy has a critical impact on mothers, foetuses and infants. The aim of this paper was to summarise key points presented by experts attending the 12th Maria Delivoria‐Papadopoulos Perinatal Symposium in March 2025 and further expand and update them.
Ariadne Malamitsi‐Puchner, Despina D. Briana, Gian Carlo Di Renzo   +2 more
wiley   +1 more source

Are We Prepared in Case of a Possible Smallpox-Like Disease Emergence?

Viruses, 2017
Smallpox was the first human disease to be eradicated, through a concerted vaccination campaign led by the World Health Organization. Since its eradication, routine vaccination against smallpox has ceased, leaving the world population susceptible to ...
Victoria A. Olson, Sergei N. Shchelkunov
doaj   +1 more source

An APOBEC3 Mutational Signature in the Genomes of Human-Infecting Orthopoxviruses

mSphere, 2023
The ongoing worldwide monkeypox outbreak is caused by viral lineages (globally referred to as hMPXV1) that are related to but distinct from clade IIb MPXV viruses transmitted within Nigeria.
Diego Forni, Rachele Cagliani, Uberto Pozzoli, Manuela Sironi   +3 more
doaj   +1 more source

Dual Use Research of Concern—The Necessity of Global Bioethics Engagement

Bioethics, EarlyView.
ABSTRACT Dual use research of concern (DURC) refers to research conducted for legitimate scientific purposes that could also be misused to pose a significant threat to public health and safety, agricultural crops and other plants, animals, the environment, or national security.
Daniel J. Hurst, Christopher A. Bobier
wiley   +1 more source

Biological warfare: The many possibilities

South African Family Practice, 2004
Biological warfare has been a threat to society for many decades. This article summarises some of the most likely organisms suitable for a bio-terrorist attack, including Bacillus anthracis, Francisella tularensis, Yersinia pestis, the agents of viral ...
E. Wasserman
doaj   +1 more source

Viral detection by electron microscopy: past, present and future. [PDF]

, 2008
International audienceViruses are very small and most of them can be seen only by TEM (transmission electron microscopy). TEM has therefore made a major contribution to virology, including the discovery of many viruses, the diagnosis of various viral ...
Ait-Goughoulte, Appleton, Biel, Bishop, Blanchard, Bousarghin, Brandenburg, Brandenburg, Brenner, Briggs, Brorson, Caul, Chan, Chua, Cossart, Coyne, Curry, Curry, Curry, Curry, Cyrklaff, Dane, Donahue, Drosten, Feinstone, Flewett, Forster, Frischknecht, Gaietta, Gardner, Giepmans, Goldsmith, Grabenbauer, Griffiths, Grigorov, Gruber, Grunewald, Guo, Hacein-Bey-Abina, Haguenau, Harris, Helenius, Henderson, Hourioux, Hourioux, Huovila, Jones, Jones, Jouvenet, Kapikian, Kapikian, Kartenbeck, Knoll, Ksiazek, Lanman, Literak, Logan, Logan, Lueders, Madeley, Madeley, Madeley, Madeley, Maeda, Marsh, Matz-Rensing, Mayo, McCaughey, McLauchlan, Medici, Miller, Morris, Murray, Nagler, Novoa, Oka, Patient, Pelchen-Matthews, Philippe Roingeard, Poel, Prukner-Radovcic, Reed, Rodak, Roingeard, Roux, Ruska, Ruska, Ruska, Tang, Tyrrell, Weiss, Welsch, Wileman   +92 more
core   +3 more sources

Immunological Memory after Exposure to Variola Virus, Monkeypox Virus, and Vaccinia Virus [PDF]

The Journal of Infectious Diseases, 2007
We compared cellular and humoral immunity to vaccinia virus (VV) in individuals exposed to 3 different orthopoxviruses: 154 individuals previously vaccinated with VV, 7 individuals with a history of monkeypox virus infection, and 8 individuals with a history of variola virus infection.
Sivapalasingam, Sumathi, Kennedy, Jeffrey S., Borkowsky, William, Valentine, Fred, Zhan, Ming-Xia, Pazoles, Pamela P., Paolino, Anna, Ennis, Francis A., Steigbigel, Neal H.   +8 more
openaire   +3 more sources