Results 71 to 80 of about 126,547 (360)

Interleukin-18 enhances vascular calcification and osteogenic differentiation of vascular smooth muscle cells through TRPM7 channel activation [PDF]

, 2017
Objective—Vascular calcification (VC) is an important predictor of cardiovascular morbidity and mortality. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is a key mechanism of VC. Recent studies show that IL-18 (interleukin-18) favors
Chen, Jie, Chen, Renhua, Feng, Weijing, Huang, Hui, Touyz, Rhian M., Wang, Jingfeng, Zhang, Kun, Zhang, Yinyin   +7 more
core   +1 more source

Relationship between effective blood flow rate and clinical outcomes in maintenance hemodialysis patients: a single-center study

Renal Failure
The association between blood flow rate (BFR) and clinical outcomes in patients undergoing maintenance hemodialysis (MHD) is inconclusive. This retrospective study included 175 patients undergoing MHD treatment between July 2015 and March 2022, divided ...
Zhoucang Zhang, Jiarui Li, Jiaxiang Ding, Shenglei Zhang, Mei Wang, Jinsheng Xu   +5 more
doaj   +1 more source

From variome to phenome : pathogenesis, diagnosis and management of ectopic mineralization disorders [PDF]

, 2015
Ectopic mineralization - inappropriate biomineralization in soft tissues - is a frequent finding in physiological aging processes and several common disorders, which can be associated with significant morbidity and mortality.
De Vilder, eva, Vanakker, Olivier
core   +2 more sources

Genetics of Vascular Calcification [PDF]

Circulation Research, 2011
### NT5E Mutations and Arterial Calcifications Hilaire et al NEJM. 2011;364:432–442. Recessive mutations in the NTE5 gene were recently described in lower-extremity vascular calcification. ENPP1 mutations were previously described in a severe disorder of vascular calcification in infancy.
openaire   +3 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Comparative efficacy of sodium thiosulfate, bisphosphonates, and cinacalcet for the treatment of vascular calcification in patients with haemodialysis: a systematic review and network meta-analysis

BMC Nephrology
Background Up to now, there is no unequivocal intervention to mitigate vascular calcification (VC) in patients with hemodialysis. This network meta-analysis aimed to systematically evaluate the clinical efficacy of sodium thiosulfate, bisphosphonates ...
Lei He, Yuzhe Li, Jingjing Jin, Meijuan Cheng, Yaling Bai, Jinsheng Xu   +5 more
doaj   +1 more source

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. [PDF]

, 2019
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending ...
Bagchi, Aranya, Barnes, Hanna J, Bloch, Donald B, Bowden, Donald W, Budoff, Matthew, Buswell, Mary D, Buys, Emmanuel S, Campbell, Catherine Y, Criqui, Michael H, Debette, Stephanie, Erbel, Raimund, Feitosa, Mary F, Franceschini, Nora, Freedman, Barry I, Gudnason, Vilmundur, Guo, Xiuqing, Harris, Tamara, Hoffmann, Udo, Hwang, Shih-Jen, Johnson, Andrew D, Jöckel, Karl-Heinz, Kälsch, Hagen, Lindsay, Mark E, Lino Cardenas, Christian L, Lu, Lingyi, Malhotra, Rajeev, Mauer, Andreas C, Moebus, Susanne, Nicholson, Christopher J, Nigwekar, Sagar U, Nöthen, Markus M, O'Donnell, Christopher J, Pechlivanis, Sonali, Post, Wendy S, Rhee, David K, Rotter, Jerome I, Rourke, Caitlin O', Shelton, Georgia, Sigurdsson, Sigurdur, Sigurslid, Haakon H, Slocum, Charles, Smith, Albert V, Song, Ci, Thanassoulis, George, Wang, Judy, Wong, Quenna, Wunderer, Florian, Yao, Jie, Zapol, Warren M, Zhang, Xiaoling   +49 more
core  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Enhancing cardiovascular risk prediction through AI-enabled calcium-omics [PDF]

arXiv, 2023
Background. Coronary artery calcium (CAC) is a powerful predictor of major adverse cardiovascular events (MACE). Traditional Agatston score simply sums the calcium, albeit in a non-linear way, leaving room for improved calcification assessments that will more fully capture the extent of disease. Objective.
arxiv