Results 11 to 20 of about 950,338 (392)

Cardiotoxicity with vascular endothelial growth factor inhibitor therapy [PDF]

npj Precision Oncology, 2018
Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway (VSP) have been important additions in the therapy of various cancers, especially renal cell carcinoma and colorectal cancer.
Herrmann, Joerg, Touyz, Rhian M.
core   +3 more sources

Effects of diabetes on myocardial capillary density and serum angiogenesis biomarkers in male rats

Clinics, 2011
INTRODUCTION: Cardiovascular disease is one of the main causes of mortality and morbidity in diabetic patients. This study evaluated the effects of diabetes on myocardial capillary density and several serum angiogenic factors including nitric oxide ...
Majid Khazaei, Ali Reza Fallahzadeh, Mohammad Reza Sharifi, Noushin Afsharmoghaddam, Shaghayegh Haghjooy Javanmard, Ensieh Salehi   +5 more
doaj   +1 more source

Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1 [PDF]

, 2018
Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from alternative splicing of the same gene. In addition to the transmembrane form, endothelial cells produce a soluble VEGFR-1 (sVEGFR-1) isoform, whereas non ...
Carbo, Miriam, Failla, Cristina M., Morea, Veronica   +2 more
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Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia [PDF]

, 2006
Background— Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of chemoattractant factors such as stromal cell–derived factor 1 and vascular endothelial growth ...
Aicher, A, Dimmeler, S, Heeschen, C, Sasaki, K, Urbich, C, Zeiher, AM   +5 more
core   +1 more source

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis [PDF]

, 2014
Methodology: We have utilized a rational in silico-based approach to demonstrate the design and study of a novel compound that acts as a dual inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) and cyclin-dependent kinase 1 (CDK1).
AM Latham, Antony M. Latham, B Apsel, Colin W. G. Fishwick, D Santamaria, Domenico Ribatti, E Schonbrunn, EA Murphy, G Bergers, G Draetta, Gareth W. Fearnley, GI Evan, GJ Howell, GW Fearnley, H Haddad, H Huynh, I Zachary, J Galon, J Kankanala, J Lee, J Pines, Jayakanth Kankanala, JC Tille, JJ Tung, JM Ebos, JW Schmidberger, K Boda, KM Malinda, M Doree, M Mohammadi, MA Ali, MA Branca, Mark T. Kearney, Matthew C. Gage, MP Jacobson, MS Squires, N Ferrara, O Timofeev, P Carmeliet, P Carmeliet, PA Harris, PG Wyatt, Q Wang, R Morphy, RA Friesner, RA Friesner, S Emanuel, S Huang, S Koch, S Koch, S Ponnambalam, Shervanthi Homer-Vanniasinkam, Sreenivasan Ponnambalam, Stephen B. Wheatcroft, T Anastassiadis, T Bashir, TA Halgren, TA Potapova, V Knights, VE Neubrand, ZW Cai   +60 more
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VEGFR2 trafficking, signaling and proteolysis is regulated by the ubiquitin isopeptidase USP8 [PDF]

, 2016
Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular function. VEGF-A binding to vascular endothelial growth factor receptor 2 (VEGFR2) stimulates endothelial signal transduction and regulates multiple cellular responses ...
Adhikari, Bruns, Bruns, Clague, Clague, Ewan, Fearnley, Gao, Horowitz, Howell, Hurley, Jopling, Jopling, Kato, Koch, Koch, Lanahan, MacDonald, McCullough, Meijer, Melker, Mizuno, Mizuno, Olsson, Pickart, Row, Sawamiphak, Shibuya, Tanaka, Wing, Zhang   +30 more
core   +1 more source

Vascular endothelial growth factors and vascular permeability [PDF]

Cardiovascular Research, 2010
Vascular endothelial growth factors (VEGFs) are key regulators of permeability. The principal evidence behind how they increase vascular permeability in vivo and in vitro and the consequences of that increase are addressed here. Detailed analysis of the published literature has shown that in vivo and in vitro VEGF-mediated permeability differs in its ...
openaire   +2 more sources

Vascular endothelial growth factor receptor-1 mRNA overexpression in peripheral blood as a useful prognostic marker in breast cancer [PDF]

, 2012
INTRODUCTION: Identification of useful markers associated with poor prognosis in breast cancer patients is critically needed. We previously showed that expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood may be useful to ...
Akemi Kataoka, Hiroaki Ueo, Hiroshi Yamaguchi, Koshi Mimori, Masahiko Watanabe, Masaki Mori, Masaru Kuranami, Norihiko Sengoku, Sayuri Akiyoshi, Shinji Ohno, Yoshimasa Kosaka   +10 more
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Porcine bone scaffolds adsorb growth factors secreted by MSCs and improve bone tissue repair [PDF]

, 2017
An ideal tissue-engineered bone graft should have both excellent pro-osteogenesis and pro-angiogenesis properties to rapidly realize the bone regeneration in vivo . To meet this goal, in this work a porcine bone scaffold was successfully used as a Trojan
Bressan, Eriberto, Ferroni, Letizia, Gardin, Chiara, Mijiritsky, Eitan, Piattelli, Adriano, Zanette, Gastone, Zavan, Barbara   +6 more
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Galectin-3 Enhances Vascular Endothelial Growth Factor-A Receptor 2 Activity in the Presence of Vascular Endothelial Growth Factor

Frontiers in Cell and Developmental Biology, 2021
Galectin-3 (Gal3) is a carbohydrate-binding protein reported to promote angiogenesis by influencing vascular endothelial growth factor-A receptor 2 (VEGFR2) signal transduction.
Issahy Cano, Issahy Cano, Zhengping Hu, Zhengping Hu, Dina B. AbuSamra, Dina B. AbuSamra, Magali Saint-Geniez, Magali Saint-Geniez, Yin Shan Eric Ng, Yin Shan Eric Ng, Pablo Argüeso, Pablo Argüeso, Patricia A. D’Amore, Patricia A. D’Amore, Patricia A. D’Amore   +14 more
doaj   +1 more source