Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels [PDF]
Frontiers in Bioengineering and Biotechnology, 2018 Because virtually all tissues contain blood vessels, the importance of hemevascularization has been long recognized in regenerative medicine and tissue engineering.
Khushbu Rauniyar +3 more
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Proceedings of the National Academy of Sciences of the United States of America, 1999 c-fos-induced growth factor/vascular endothelial growth factor D (Figf/Vegf-D) is a secreted factor of the VEGF family that binds to the vessel and lymphatic receptors VEGFR-2 and VEGFR-3.
Lucia Marconcini +7 more
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Vascular endothelial growth factor-C in activating vascular endothelial growth factor receptor-3 and chemokine receptor-4 in melanoma adhesion. [PDF]
J Cell Mol Med, 2022 AbstractVascular endothelial growth factor‐C (VEGF‐C) binds to receptor vascular endothelial growth factor receptor‐3 (VEGFR‐3) expressed on lymphatic endothelial and melanoma cells. Binding of VEGF‐C to VEGFR‐3 enhances receptor phosphorylation that activates mitogen‐activated protein kinase (MAP‐K) and phosphatidylinositol‐3‐kinase (PI3K).
Hlophe YN, Joubert AM.
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Proximal tubule dysfunction is associated with podocyte damage biomarkers nephrin and vascular endothelial growth factor in type 2 diabetes mellitus patients: a cross-sectional study. [PDF]
PLoS ONE, 2014 There is an ongoing debate as to whether early diabetic nephropathy in Type 2 diabetes mellitus may be attributed to the glomerulus or to the proximal tubule.
Ligia Petrica +11 more
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Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases. [PDF]
J Am Soc Nephrol, 2016 Polycystic kidney diseases (PKD) are genetic disorders characterized by progressive epithelial cyst growth leading to destruction of normally functioning renal tissue. Current therapies have focused on the cyst epithelium, and little is known about how the blood and lymphatic microvasculature modulates cystogenesis.
Huang JL +9 more
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Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis [PDF]
The EMBO Journal, 2001 Metastasis is a frequent and lethal complication of cancer. Vascular endothelial growth factor-C (VEGF-C) is a recently described lymphangiogenic factor. Increased expression of VEGF-C in primary tumours correlates with dissemination of tumour cells to regional lymph nodes.
Stefano J. Mandriota
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Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy [PDF]
British Journal of Cancer, 2003 Vascular endothelial growth factor-C (VEGF-C) and VEGF-D are members of the VEGF family of cytokines and have angiogenic and lymphangiogenic actions. In gastric adenocarcinoma, VEGF-C mRNA and tissue protein expression correlate with lymphatic invasion, lymph node metastasis and in some reports, venous invasion and reduced 5-year survival.
Sarah Duff +7 more
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Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma [PDF]
Cancer, 2004 AbstractBACKGROUNDThe vascular endothelial growth factor (VEGF) family and VEGF receptors (VEGFR) play an essential role in the angiogenesis of both pathologic and nonpathologic conditions. However, the prognostic significance of VEGF and VEGFR expression in ovarian carcinoma is unclear.METHODSThe tissue expression levels of VEGF‐A, VEGF‐C, VEGFR‐2 ...
Naoyo Nishida +5 more
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Vascular endothelial growth factor-C: its unrevealed role in fibrogenesis. [PDF]
Am J Physiol Heart Circ Physiol, 2014 Vascular endothelial growth factor (VEGF)-C is a key mediator of lymphangiogenesis. Our recent study shows that VEGF-C/VEGF receptors (VEGFR)-3 are significantly increased in the infarcted rat myocardium, where VEGFR-3 is expressed not only in lymph ducts but also in myofibroblasts, indicating that VEGF-C has an unrevealed role in fibrogenesis during ...
Zhao T +5 more
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Folia Histochemica et Cytobiologica, 2009 To evaluate the immunohistochemical expression of VEGF-C, CD34 and VEGFR-2 in cancer tissue of children diagnosed with stadium 4 neuroblastoma (NB) and correlate their presence with the survival rate of children diagnosed with that stage of the disease ...
Bogdan Miskowiak +7 more
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