Dynamic soluble changes in sVEGFR1, HGF, and VEGF promote chemotherapy and bevacizumab resistance: A prospective translational study in the BECOX (GEMCAD 09-01) trial [PDF]
Tumor Biology, 2017 Despite initial responsiveness, acquired resistance to both bevacizumab and chemotherapy in metastatic colorectal cancer is universal. We have recently published that in vitro, chronically oxaliplatin resistance upregulates soluble vascular endothelial ...
Estela Pineda +19 more
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Vascular endothelial growth factor-C in activating vascular endothelial growth factor receptor-3 and chemokine receptor-4 in melanoma adhesion. [PDF]
J Cell Mol Med, 2022 AbstractVascular endothelial growth factor‐C (VEGF‐C) binds to receptor vascular endothelial growth factor receptor‐3 (VEGFR‐3) expressed on lymphatic endothelial and melanoma cells. Binding of VEGF‐C to VEGFR‐3 enhances receptor phosphorylation that activates mitogen‐activated protein kinase (MAP‐K) and phosphatidylinositol‐3‐kinase (PI3K).
Hlophe YN, Joubert AM.
europepmc +4 more sources
FIGF (c-fos induced growth factor (vascular endothelial growth factor D)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on FIGF (c-fos induced growth factor (vascular endothelial growth factor D)), with data on DNA, on the protein encoded, and where the gene is implicated.
Marina Rocchigiani, Salvatore Oliviero
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Mononuclear Phagocyte System Depletion Blocks Interstitial Tonicity-Responsive Enhancer Binding Protein/Vascular Endothelial Growth Factor C Expression and Induces Salt-Sensitive Hypertension in Rats [PDF]
, 2010 We showed recently that mononuclear phagocyte system (MPS) cells provide a buffering mechanism for salt-sensitive hypertension by driving interstitial lymphangiogenesis, modulating interstitial Na(+) clearance, and increasing endothelial NO synthase ...
Agnes Machnik +11 more
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Association of serum vascular endothelial growth factor-C, vascular endothelial growth factor receptor-3, and insulin-like growth factor 1 levels with metastasis and prognosis in patients with nasopharyngeal carcinoma [PDF]
Frontiers in OncologyObjectiveTo investigate the association of serum levels of Vascular Endothelial Growth Factor-C (VEGFC), Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3), and Insulin-like Growth Factor 1 (IGF1) with metastasis and prognosis in patients with ...
Yongchun Li +4 more
doaj +2 more sources
Analysis of research hotspots on the detection of vascular endothelial growth factor C and its receptor vascular endothelial growth factor receptor-3 in cervical squamous cell carcinoma [PDF]
Discover OncologyCervical squamous cell carcinoma (CSCC) remains a prevalent malignancy among women worldwide, with lymphatic metastasis critically influencing prognosis.
Yaowen Hu, Qun Fang
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Direct sensing of endothelial oxidants by vascular endothelial growth factor receptor-2 and c-Src. [PDF]
PLoS ONE, 2011 BACKGROUND: ADPH oxidase-derived reactive oxygen species (ROS) play important roles in redox homeostasis and signal transduction in endothelial cells (ECs).
Monica Lee, Wing C Choy, Md Ruhul Abid
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Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases. [PDF]
J Am Soc Nephrol, 2016 Polycystic kidney diseases (PKD) are genetic disorders characterized by progressive epithelial cyst growth leading to destruction of normally functioning renal tissue. Current therapies have focused on the cyst epithelium, and little is known about how the blood and lymphatic microvasculature modulates cystogenesis.
Huang JL +9 more
europepmc +6 more sources
Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels [PDF]
Frontiers in Bioengineering and Biotechnology, 2018 Because virtually all tissues contain blood vessels, the importance of hemevascularization has been long recognized in regenerative medicine and tissue engineering.
Khushbu Rauniyar +3 more
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Vascular Endothelial Growth Factor-C Accelerates Diabetic Wound Healing [PDF]
The American Journal of Pathology, 2006 Diabetes impairs numerous aspects of tissue repair. Failure of wound angiogenesis is known to delay diabetic wound healing, whereas the importance of lymphangiogenesis for wound healing is unclear. We have examined whether overexpression of vascular endothelial growth factor (VEGF)-C via an adenoviral vector could improve the healing of full-thickness ...
Anne Saaristo +6 more
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