Results 71 to 80 of about 932,558 (375)

Homologous Up-regulation of KDR/Flk-1 Receptor Expression by Vascular Endothelial Growth Factor in Vitro *

Journal of Biological Chemistry, 1998
We investigated the possibility that vascular endothelial growth factor (VEGF) treatment could regulate KDR/Flk-1 receptor expression in endothelial cells. Bovine adrenal cortex endothelial cells were incubated with 200 pmrhVEGF165 for 0–7 days.
Ben-Quan Shen, D. Y. Lee, H. Gerber, B. Keyt, N. Ferrara, T. F. Zioncheck   +5 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Shared features of endothelial dysfunction between sepsis and its preceding risk factors (aging and chronic disease) [PDF]

, 2018
Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,increasing vascular permeability, promoting activation of the coagulation cascade, tissue edema and compromising perfusion of vital organs. Aging and chronic diseases(hypertension,dyslipidaemia,diabetes mellitus,chronic kidney disease,cardiovascular disease ...
arxiv   +1 more source

DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination

Journal of Extracellular Vesicles, 2020
Early dissemination is a unique characteristic and a detrimental process of pancreatic ductal adenocarcinoma (PDAC); however, the underlying mechanism remains largely unknown.
Chu-An Wang, I-Heng Chang, Pei-Chi Hou, Yu-Jing Tai, Wan-Ning Li, Pei-Ling Hsu, Shang-Rung Wu, Wen-Tai Chiu, Chien-Feng Li, Yan-Shen Shan, Shaw-Jenq Tsai   +10 more
doaj   +1 more source

Adiponectin regulates vascular endothelial growth factor-C expression in macrophages via Syk-ERK pathway. [PDF]

PLoS ONE, 2013
Adiponectin is exclusively expressed in adipose tissues and exhibits protective effects against cardiovascular and metabolic diseases. It enhances AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor α (PPARα) signaling in the liver
Di Hu, Atsunori Fukuhara, Yugo Miyata, Chieko Yokoyama, Michio Otsuki, Shinji Kihara, Iichiro Shimomura   +6 more
doaj   +1 more source

Clinical significance of vascular endothelial growth factor‐C and vascular endothelial growth factor receptor 3 in patients with T1 lung adenocarcinoma [PDF]

Cancer, 2005
AbstractBACKGROUNDVascular endothelial growth factor‐C (VEGF‐C) plays an important role in lymphangiogenesis and activates VEGF receptor‐3 (VEGFR‐3). Lymphatic spread is an important prognostic factor in patients with lung adenocarcinoma. The aim of the current study was to determine whether the expression of VEGF‐C and VEGFR‐3 correlates with ...
Gen Yamada, Noriyuki Sato, Shosaku Abe, Masaaki Satoh, Shingo Ichimiya, Hiroshi Kojima, Noriharu Shijubo   +6 more
openaire   +3 more sources

Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Tissue factor (TF), a transmembrane receptor for coagulation factor VII/VIIa, is aberrantly expressed in human cancers. We demonstrated a significant correlation between TF and vascular endothelial growth factor (VEGF) production in 13 human malignant ...
K. Abe, M. Shoji, Jiang Chen, A. Bierhaus, I. Danave, Cornelia Micko, K. Casper, D. Dillehay, P. Nawroth, F. Rickles   +9 more
semanticscholar   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis

Angiogenesis, 2013
Endometriosis is an angiogenesis-dependent disease. Many studies demonstrated inhibition of angiogenesis leads to inhibition of endometriotic growth, however underlying mechanism is still not fully understood. Our previous study suggested vascular endothelial growth factor C (VEGF-C) as a target of anti-angiogenesis therapy for endometriosis.
Xu, Hui, Zhang, Tao, Man, Gene Chi Wai, Maiden_Name, Katie E, Becker, Christian M, Davis, Tina N, Kung, Andrew L, Birsner, Amy E, D'Amato, Robert J, Wong, Alice Wai Yee, Wang, Chi Chiu   +10 more
openaire   +5 more sources

Hypoxic Regulation of Vascular Endothelial Growth Factor through the Induction of Phosphatidylinositol 3-Kinase/Rho/ROCK and c-Myc*

Journal of Biological Chemistry, 2006
The induction of vascular endothelial growth factor (VEGF) is an essential feature of tumor angiogenesis. Hypoxia is a potent stimulator of VEGF expression, and hypoxia-inducible factor-1 (HIF-1) is considered to be critical for this induction.
Y. Mizukami, K. Fujiki, E. Duerr, M. Gala, Won-Seok Jo, Xiaobo Zhang, D. Chung   +6 more
semanticscholar   +1 more source