Results 1 to 10 of about 385,157 (356)
Vascular smooth muscle cell dysfunction in neurodegeneration
Frontiers in Neuroscience, 2022 Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics in response to the brain’s oxygen and nutrient demands. Crucially, VSMCs may provide a sensitive biomarker for neurodegenerative pathologies where vasculature is ...
Genevieve Hayes +7 more
doaj +3 more sources
Regulation of the cell magnesium in vascular smooth muscle
The Journal of Physiology, 1974 1. The relation between [Mg]o and the Mg content of the rat tail artery incubated in Ca‐free solutions was studied.2. Variation of [Mg]o in Ca‐free Krebs solution between 0·6 and 2·4 m m did not affect the cell Mg. In ATP‐depleted arteries, a sizeable fraction of the cell Mg was found to be proportional to [Mg]o.3.
Vladimír Palatý
openalex +5 more sources
Characterization of ectonucleotidases on vascular smooth-muscle cells [PDF]
Biochemical Journal, 1985 We compared the properties of the ectonucleotidases (nucleoside triphosphatase, EC 3.6.1.15; nucleoside diphosphatase, EC 3.6.1.6; 5′-nucleotidase, EC 3.1.3.5) in intact pig aortic smooth-muscle cells in culture with the properties that we previously investigated for ectonucleotidases of aortic endothelial cells [Cusack, Pearson & Gordon (1983 ...
Jeremy D. Pearson +2 more
openalex +4 more sources
Vascular smooth muscle cell phenotypic switching in atherosclerosis [PDF]
HeliyonAtherosclerosis (AS) is a complex pathology process involving intricate interactions among various cells and biological processes. Vascular smooth muscle cells (VSMCs) are the predominant cell type in normal arteries, and under atherosclerotic stimuli ...
Yanqiao Yu +6 more
doaj +2 more sources
EPAC in Vascular Smooth Muscle Cells [PDF]
International Journal of Molecular Sciences, 2020 Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over ...
Firas Kobeissy +10 more
openaire +3 more sources
Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cells in vitro
Frontiers in Physiology, 2022 Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating the importance of transcription factor GATA6 in vascular smooth muscle, the functional role of GATA6 ...
Azra Alajbegovic +6 more
doaj +1 more source
Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. [PDF]
PLoS ONE, 2015 Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including ...
Jennifer M Kleinhenz +10 more
doaj +1 more source
Vascular smooth muscle cells in atherosclerosis [PDF]
Nature Reviews Cardiology, 2019 Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the 'response to injury' and 'vulnerable plaque' hypotheses, contractile VSMCs recruited from the media undergo phenotypic conversion to proliferative synthetic cells that generate extracellular matrix to form the fibrous cap and ...
Martin R. Bennett +6 more
openaire +4 more sources
Smoothelin in Vascular Smooth Muscle Cells [PDF]
Trends in Cardiovascular Medicine, 2007 Smoothelin-A and -B have only been found in fully differentiated contractile smooth muscle cells. They are increasingly used to monitor the smooth muscle cell differentiation process to a contractile or synthetic phenotype. Vascular-specific smoothelin-B is the first smooth muscle cell marker that disappears when vascular tissues are compromised, for ...
Petra Niessen +2 more
openaire +4 more sources
Smooth muscle cells and vascular diseases [PDF]
Cardiovascular Research, 2012 Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, and, due to their myosin/actin interactions, they are also responsible for arterial contractile tonus and regulating blood pressure and flow in relation to specific metabolic demands.
Jean-Baptiste Michel +2 more
openaire +3 more sources