Results 11 to 20 of about 236,813 (316)

The role of p53 in the alternation of vascular functions

Frontiers in Pharmacology, 2022
Ageing is a risk factor for many degenerative diseases. Cardiovascular diseases (CVDs) are usually big burdens for elderly, caregivers and the health system.
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto, Sai-Wang Seto, Sai-Wang Seto   +7 more
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Vascular smooth muscle cells in atherosclerosis [PDF]

Nature Reviews Cardiology, 2019
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the 'response to injury' and 'vulnerable plaque' hypotheses, contractile VSMCs recruited from the media undergo phenotypic conversion to proliferative synthetic cells that generate extracellular matrix to form the fibrous cap and ...
Basatemur, Gemma L, Jørgensen, Helle F, Clarke, Murray CH, Bennett, Martin R, Mallat, Ziad   +4 more
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Endothelial cell-derived extracellular vesicles alter vascular smooth muscle cell phenotype through high-mobility group box proteins

Journal of Extracellular Vesicles, 2020
The vascular endothelium and smooth muscle form adjacent cellular layers that comprise part of the vascular wall. Each cell type can regulate the other’s structure and function through a variety of paracrine effectors.
Michael J. Boyer, Yayoi Kimura, Tomoko Akiyama, Ariele Y. Baggett, Kyle J. Preston, Rosario Scalia, Satoru Eguchi, Victor Rizzo   +7 more
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TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms

JACC: Basic to Translational Science, 2023
Summary: Phenotypic switching of vascular smooth muscle cells is a central process in abdominal aortic aneurysm (AAA) pathology. We found that knockdown TCF7L1 (transcription factor 7-like 1), a member of the TCF/LEF (T cell factor/lymphoid enhancer ...
Jing Wang, MM, Xiaoxiang Tian, MD, Chenghui Yan, MD, Hanlin Wu, MM, Yuxin Bu, MM, Jia Li, MD, Dan Liu, MD, Yaling Han, MD, PhD   +7 more
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Smooth Muscle Cells for Vascular Engineering [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2011
In the first decade of this century, ever-increasing scientific and technological advances are revolutionizing our approaches to developing therapies that bring about the promise of personalized medicine and the possibility of regenerative interventions.
Y Eugene, Chen, Changqing, Xie, Milton, Hamblin   +2 more
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Vascular Smooth Muscle Cells [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2016
Decades of work have shown that vascular smooth muscle cell (SMC) phenotypes are controlled by cues received from the local environment.1–3 When nestled into a cage of cross-linked collagen and elastin of its own making,4 medial SMCs exhibit a fully differentiated phenotype conferred by the transcriptional activity of myocardin and serum response ...
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Vascular Smooth Muscle Cells in Atherosclerosis [PDF]

Circulation Research, 2016
The historical view of vascular smooth muscle cells (VSMCs) in atherosclerosis is that aberrant proliferation of VSMCs promotes plaque formation, but that VSMCs in advanced plaques are entirely beneficial, for example preventing rupture of the fibrous cap.
Martin R, Bennett, Sanjay, Sinha, Gary K, Owens   +2 more
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Smooth muscle cells largely develop independently of functional hemogenic endothelium

Stem Cell Research, 2014
Vascular smooth muscle cells represent a major component of the cardiovascular system. In vitro studies have shown that FLK1+ cells derived from embryonic stem (ES) cells can differentiate into both endothelial and smooth muscle cells.
Monika Stefanska, Guilherme Costa, Michael Lie-a-Ling, Valerie Kouskoff, Georges Lacaud   +4 more
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Vascular smooth muscle cell differentiation – 2010 [PDF]

Journal of Biomedical Research, 2010
Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes ...
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iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling. [PDF]

PLoS ONE, 2012
Calcium independent group VIA phospholipase A(2) (iPLA(2)β) is up-regulated in vascular smooth muscle cells in some diseases, but whether the up-regulated iPLA(2)β affects vascular morphology and blood pressure is unknown.
Lindsay E Calderon, Shu Liu, Wen Su, Zhongwen Xie, Zhenheng Guo, Wanda Eberhard, Ming C Gong   +6 more
doaj   +1 more source