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Specialized mouse embryonic stem cells for studying vascular development [PDF]
Stem Cells and Cloning: Advances and Applications, 2014 Drew E Glaser,1 Andrew B Burns,2 Rachel Hatano,2 Magdalena Medrzycki,3 Yuhong Fan,3 Kara E McCloskey1 1School of Engineering, University of California, Merced, CA, USA; 2School of Natural Sciences, University of California, Merced, CA, USA; 3School of ...
Glaser DE +5 more
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The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension [PDF]
Journal of Experimental Pharmacology, 2012 Richard E RobertsSchool of Biomedical Sciences, University of Nottingham, Nottingham, United KingdomAbstract: Hypertension is a risk factor for myocardial infarction, stroke, renal failure, heart failure, and peripheral vascular disease.
Roberts RE
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EPAC in Vascular Smooth Muscle Cells [PDF]
International Journal of Molecular Sciences, 2020 Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over ...
Nadine Wehbe +9 more
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Role of smooth muscle progenitor cells in vascular mechanical injury and repair
Medicine in Novel Technology and Devices, 2022 Smooth muscle progenitor cells are precursor cells that express both smooth muscle cell and stem cell markers, and can differentiate into smooth muscle cells under specific condition.
Zhu-feng Dong +7 more
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Long non-coding RNAs: Modulators of phenotypic transformation in vascular smooth muscle cells
Frontiers in Cardiovascular Medicine, 2022 Long non-coding RNA (lncRNAs) are longer than 200 nucleotides and cannot encode proteins but can regulate the expression of genes through epigenetic, transcriptional, and post-transcriptional modifications.
Bing-Han Lu +16 more
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Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching [PDF]
, 2012 Bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs) synthesis, reduces neointimal formation in animal models of vascular injury and recently has been shown to inhibit in-stent late loss in a placebo-controlled phase II clinical trial.
Angelo Guglielmotti +12 more
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Smoothelin in Vascular Smooth Muscle Cells [PDF]
Trends in Cardiovascular Medicine, 2007 Smoothelin-A and -B have only been found in fully differentiated contractile smooth muscle cells. They are increasingly used to monitor the smooth muscle cell differentiation process to a contractile or synthetic phenotype. Vascular-specific smoothelin-B is the first smooth muscle cell marker that disappears when vascular tissues are compromised, for ...
van Eys, G.J.J.M. +2 more
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Vinpocetine Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells. [PDF]
PLoS ONE, 2016 Vascular calcification is an active process of osteoblastic differentiation of vascular smooth muscle cells; however, its definite mechanism remains unknown.
Yun-Yun Ma +8 more
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Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cells in vitro
Frontiers in Physiology, 2022 Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating the importance of transcription factor GATA6 in vascular smooth muscle, the functional role of GATA6 ...
Azra Alajbegovic +6 more
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Cells, 2021 Among reactive oxygen species, superoxide mediates the critical vascular redox signaling, resulting in the regulation of the human cardiovascular system.
Kazumi Takaishi +3 more
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