Results 51 to 60 of about 513,814 (378)
Cardiovascular Research, 2018 Vascular calcification is associated with a significant increase in all-cause mortality and atherosclerotic plaque rupture. Calcification has been determined to be an active process driven in part by vascular smooth muscle cell (VSMC ...
A. Durham +4 more
semanticscholar +1 more source
Vascular smooth muscle cell differentiation – 2010 [PDF]
Journal of Biomedical Research, 2010 Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes ...
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Increased neointimal thickening in dystrophin-deficient mdx mice.
PLoS ONE, 2012 BackgroundThe dystrophin gene, which is mutated in Duchenne muscular dystrophy (DMD), encodes a large cytoskeletal protein present in muscle fibers. While dystrophin in skeletal muscle has been extensively studied, the function of dystrophin in vascular ...
Uwe Rauch +5 more
doaj +1 more source
Analysis of a new multispecies tumor growth model coupling 3D phase-fields with a 1D vascular network [PDF]
Nonlinear Analysis: Real World Applications,61 (2021), p. 103331, 2020 In this work, we present and analyze a mathematical model for tumor growth incorporating ECM erosion, interstitial flow, and the effect of vascular flow and nutrient transport. The model is of phase-field or diffused-interface type in which multiple phases of cell species and other constituents are separated by smooth evolving interfaces.
arxiv +1 more source
Stem cells, vascular smooth muscle cells and atherosclerosis.
Histology and histopathology, 2006 Stem cells have the ability to differentiate into a variety of cells to replace dead cells or to repair tissue. Recently, accumulating evidence indicates that mechanical forces, cytokines and other factors can influence stem cell differentiation into vascular smooth muscle cells (SMCs).
Margariti, A., Zeng, L., Xu, Q.
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Frontiers in Cell and Developmental Biology, 2021 Blood outgrowth smooth muscle cells (BO-SMCs) offer the means to study vascular cells without the requirement for surgery providing opportunities for drug discovery, tissue engineering, and personalized medicine.
Blerina Ahmetaj-Shala +15 more
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Measurements and System Identification for the Characterization of Smooth Muscle Cell Dynamics [PDF]
2024 IEEE International Symposium on Medical Measurements and
Applications (MeMeA)Biological tissue integrity is actively maintained by cells. It is essential to comprehend how cells accomplish this in order to stage tissue diseases. However, addressing the complexity of a cell's system of interrelated mechanisms poses a challenge.
arxiv +1 more source
Replication of smooth muscle cells in vascular disease. [PDF]
Circulation Research, 1986 Smooth muscle proliferation has been recognized as central to the pathology of both major forms of vascular disease: atherosclerosis and hypertension. Recent advances in our knowledge of mechanisms of control of proliferation suggest that events occurring in adult animals may recapitulate portions of the developmental biology of the smooth muscle cell.
Schwartz, SM, Campbell, GR, Campbell, JH
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Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Cell Transplantation, 1997 Intimal hyperplasia in blood vessels is primarily caused by the migration and proliferation of vascular smooth muscle cells. Excessive intimal thickening characterizes atherosclerosis as well as bypass graft and angioplasty failures.
Alison T. Stopeck M.D. +2 more
doaj +1 more source