Results 61 to 70 of about 202,203 (296)

ARTERIAL STIFFNESS AS A RISK FACTOR FOR CEREBRAL VASCULAR LESIONS

Artery Research, 2018
Increased arterial stiffness, a biomarker of vascular aging, is a recognized subclinical organ damage, and may thus serve as predictor of cardiovascular disease.
Dariusz Gasecki
doaj   +1 more source

Matrix Stiffness Induces Pericyte-Fibroblast Transition Through YAP Activation

Frontiers in Pharmacology, 2021
Vascular pericytes, important mural cells that retain progenitor cell properties and protect vascular integrity in healthy tissues, are often associated with tumor development, but their functions in cancer invasion remain elusive.
Feng Feng, Feng Feng, Xueyan Feng, Xueyan Feng, Di Zhang, Di Zhang, Qilong Li, Qilong Li, Li Yao, Li Yao   +9 more
doaj   +1 more source

Circulating adhesion molecules and arterial stiffness [PDF]

, 2015
Aim: VCAM-1 and ICAM-1 are two important members of the immunoglobulin gene superfamily of adhesion molecules, and their potential role as biomarkers of diagnosis, severity and prognosis of cardiovascular disease has been investigated in a number of ...
Alihanoglu, Y.I., Evrengul, H., Findikoglu, G., Kılıç, İsmail Doğu, Rota, S., Uslu, S., Yildiz, B.S.   +6 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Short-term impact of aged garlic extract on endothelial function in diabetes: A randomized, double-blind, placebo-controlled trial. [PDF]

, 2020
Impaired endothelial function portends an increased risk of cardiovascular disease. Vascular oxidative stress and systemic inflammation play a critical role in the pathogenesis and progression of vascular disease.
Birudaraju, Divya, Budoff, Matthew J, Chaganti, Bhanu T, Cherukuri, Lavanya, Flores, Ferdinand, Hamal, Sajad, Kinninger, April, Matsumoto, Suguru, Roy, Sion K, Shaikh, Kashif   +9 more
core  

Vascular smooth muscle contraction in hypertension [PDF]

, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure, Anagnostopoulou, Aikaterini, Arner, Anders, De Lucca Camargo, Livia, Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian M.   +6 more
core   +1 more source

Arterial Stiffness – A Measurable Vascular Marker in Clinical Practice

APIK Journal of Internal Medicine, 2021
Arterial stiffness results from the changes in the walls of the large vessels and aorta. It has been incriminated in the pathogenesis of cardiovascular disorders. Its association with the major risk factors and atherosclerosis has been explored. Pulse wave velocity (PWV) is generally measured to evaluate it.
Nagaraj Desai, C R Venkatesh, Prabhakar Koregol   +2 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Unravelling the impact of active and passive contributors to arterial stiffness in male mice and their role in vascular aging

Scientific Reports
Arterial stiffness, a key indicator of vascular health, encompassing active (vascular tone) and passive (extracellular matrix) components. This study aims to address how these different components affect arterial stiffness along the aorta and the ...
Callan D. Wesley, Cedric H. G. Neutel, Guido R. Y. De Meyer, Wim Martinet, Pieter-Jan Guns   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source