Results 131 to 140 of about 22,016 (234)
Aging Cell, Volume 25, Issue 3, March 2026.Model showing decline in HKDC1 gene expression with aging. In a young cell, TFEB gets recruited to its binding sites on the HKDC1 promoter to upregulate HKDC1 expression, which interacts with mitochondria and stabilizes PINK1 to maintain mitochondrial health.
Zeenat Farooq +8 more
wiley +1 more source
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. [PDF]
, 2002 We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead to NFkappaB activation and collagenase-1 (CL-1)/matrix ...
Werb, Zena, Werner, Erica
core
Modulation of mitochondrial calcium as a pharmacological target for Alzheimer's disease [PDF]
, 2010 Perturbed neuronal calcium homeostasis is a prominent feature in Alzheimer's disease (AD). Mitochondria accumulate calcium ions (Ca2+) for cellular bioenergetic metabolism and suppression of mitochondrial motility within the cell.
Chang, RCC, Ho, YS, Hung, CHL
core +1 more source
Aging Cell, Volume 25, Issue 3, March 2026.Cardiac aging promotes mitochondrial AGE accumulation driven by defective glycative stress detoxification. AGE‐modified mitochondria disrupt lysosomal proteolysis, impairing mitophagy and promoting lipofuscin buildup. This mechanism sustains chronic unresolved mitochondrial damage, driving proinflammatory senescence in cardiomyocytes and defining a ...
Diana Bou‐Teen +13 more
wiley +1 more source
Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling. [PDF]
, 2014 SIGNIFICANCE: Mitochondrial ion channels/transporters and the electron transport chain (ETC) serve as key sensors and regulators for cellular redox signaling, the production of reactive oxygen species (ROS) and nitrogen species (RNS) in mitochondria, and
Hurst, Stephen +4 more
core +2 more sources
Cell Proliferation, Volume 59, Issue 3, March 2026.Pioglitazone suppresses mitochondrial excessive ROS generation and COX‐2 level through inhibition of Drp‐1 mediated mitochondrial fission in an AMPK‐dependent manner in LS. ABSTRACT Loss of function mutations of NDUFS4 resulted in Leigh syndrome, which is a progressive neurodegenerative disease and characterized by mitochondrial oxidative stress ...
Jie Luo +5 more
wiley +1 more source
HIV-1 promonocytic and lymphoid cell lines: an in vitro model of in vivo mitochondrial and apoptotic lesion. [PDF]
, 2016 To characterize mitochondrial/apoptotic parameters in chronically human immunodeficiency virus (HIV-1)-infected promonocytic and lymphoid cells which could be further used as therapeutic targets to test pro-mitochondrial or anti-apoptotic strategies as ...
Bañó, Maria +12 more
core +1 more source
A Proteomic Study of Memory After Imprinting in the Domestic Chick. [PDF]
, 2015 The intermediate and medial mesopallium (IMM) of the domestic chick forebrain has previously been shown to be a memory system for visual imprinting. Learning-related changes occur in certain plasma membrane and mitochondrial proteins in the IMM.
Margvelani, Giorgi +4 more
core +2 more sources
Frontiers in Physiology, 2019 Tubulin is a well-established target of microtubule-targeting agents (MTAs), a widely used class of chemotherapeutic drugs. Yet, aside from their powerful anti-cancer efficiency, MTAs induce a dose-limiting and debilitating peripheral neurotoxicity ...
Amandine Rovini
doaj +1 more source
Role of cysteines in mammalian VDAC isoforms' function
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016 In this mini-review, we analyze the influence of cysteines in the structure and activity of mitochondrial outer membrane mammalian VDAC isoforms. The three VDAC isoforms show conserved sequences, similar structures and the same gene organization. The meaning of three proteins encoded in different chromosomes must thus be searched for subtle differences
DE PINTO, Vito Nicola +4 more
openaire +2 more sources