Reversible Blockade of Complex I or Inhibition of PKCβ Reduces Activation and Mitochondria Translocation of p66\u3csup\u3eShc\u3c/sup\u3e to Preserve Cardiac Function after Ischemia [PDF]
, 2014 Aim Excess mitochondrial reactive oxygen species (mROS) play a vital role in cardiac ischemia reperfusion (IR) injury. P66Shc, a splice variant of the ShcA adaptor protein family, enhances mROS production by oxidizing reduced cytochrome c to yield H2O2 ...
Camara, Amadou K.S. +4 more
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Scientific Reports, 2017 Mycobacterium avium subsp. hominissuis is associated with infection of immunocompromised individuals as well as patients with chronic lung disease. M. avium infects macrophages and actively interfere with the host killing machinery such as apoptosis and ...
Lia Danelishvili +4 more
doaj +1 more source
Ekspresi Gen Family Bcl-2 dan Ekspresi Gen Protein Kanal Ion Vdac1 pada Oligozoospermia
Jurnal Kesehatan Andalas, 2014 AbstrakSalah satu bentuk infertilitas pada pria adalah jumlah spermatozoa yang kurang dari normal (Oligozoospermia). Berbagai mekanisme diduga berperan dalam terjadinya oligozoospermia, mulai dari faktor fisik, stress, makanan dan molekuler.
Arni Amir
doaj
El 17β-Estradiol y la Testosterona protegen a las mitocondrias contra el estrés oxidativo en Células del Músculo Esquelético [PDF]
, 2014 En trabajos previos demostramos que la testosterona (T) y el 17β-estradiol (E2) protegen a las células musculares C2C12 de la apoptosis inducida por peróxido de hidrógeno (H2O2).
Boland, Ricardo Leopoldo +5 more
core +1 more source
The VDAC channel: Molecular basis for selectivity
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016 The voltage dependent anion-selective channel, VDAC, is the major permeability pathway by which molecules and ion cross the mitochondrial outer membrane. This pathway has evolved to optimize the flow of these substances and to control this flow by a gating process that is influenced by a variety of factors including transmembrane voltage.
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016 Mitochondrial energy in cardiac cells has been reported to be channeled into the cytosol through the intermembrane contact sites formed by the adenine nucleotide translocator, creatine kinase and VDAC. Computational analysis performed in this study showed a high probability of the outer membrane potential (OMP) generation coupled to such a mechanism of
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The Berberine Derivative BBR684 Inhibits VDAC Oligomerization to Suppress Ferroptosis in Acute Kidney Injury. [PDF]
Curr Ther Res Clin ExpJiang Z +5 more
europepmc +1 more source
Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis
, 2009 The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial
Brinkmann, V. +14 more
core
The N-terminal α helix domain of the mitochondrial VDAC protein Por2 is dispensable for promoting the nuclear localization of yeast AMPK. [PDF]
MicroPubl BiolBrown K +3 more
europepmc +1 more source
Three mammalian VDAC isoforms distinctly regulate mitochondrial function and proteome to maintain cell metabolism. [PDF]
J Biol ChemRajendran M +11 more
europepmc +1 more source