Results 101 to 110 of about 9,347 (172)

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

Rare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu, Ming Deng, Tao Ge, Li Xu, Xinnan Xu, Kaiqi Jin   +5 more
wiley   +1 more source

The anticancer effect of metformin targets VDAC1 via ER-mitochondria interactions-mediated autophagy in HCC

Experimental and Molecular Medicine
Metformin (MetF) is used worldwide as a first-line therapy for type 2 diabetes. Recently, interest in the pleiotropic effects of MetF, such as its anticancer and antiaging properties, has increased.
Minjeong Ko, Jiho Kim, Raudah Lazim, Ju Yeon Lee, Jin Young Kim, Vijayakumar Gosu, Yoonji Lee, Sun Choi, Ho Jeong Kwon   +8 more
doaj   +1 more source

Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice

Cell Death Discovery
Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive.
Dongyun Wang, Yue Li, Guiying Li, Mengyu Liu, Zihui Zhou, Ming Wu, Shan Song, Yawei Bian, Jiajia Dong, Xinran Li, Yunxia Du, Tao Zhang, Yonghong Shi   +12 more
doaj   +1 more source

VDAC1 Gene [PDF]

, 2020
openaire   +1 more source

VDAC1 wt Allele [PDF]

, 2020
openaire   +1 more source

Role of VDAC1 hypoxic form, VDAC1-∆C, in the expression of primary cilia and tumor progression

, 2019
Voltage-dependent anion channel1 (VDAC1) is a porin of the mitochondrial outer membrane that plays a very important role in the regulation of cellular metabolism and apoptosis. As a consequence of hypoxia (i.e. decrease of oxygen availability), a new form of VDAC1, VDAC1-∆C, is produced from a microfusion between abnormally enlarged mitochondria and ...
openaire   +1 more source

The Native Conformation of the Human VDAC1 N Terminus

Angewandte Chemie International Edition, 2010
Schneider, R., Etzkorn, M., Giller, K., Daebel, V., Eisfeld, J., Zweckstetter, M., Griesinger, C., Becker, S., Lange, A.   +8 more
openaire   +4 more sources

VDAC1 protein derived from extracellular vesicles promotes paclitaxel resistance in gastric cancer through autophagy and mitophagy. [PDF]

Cancer Biol Med
Bi Y, Wei S, Zhang Z, Wang Y, Wen Y, Wang H, Li K, Zhang C, Wang Y, Zhao L, Sun G.   +10 more
europepmc   +1 more source