Results 111 to 120 of about 10,788 (194)

Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice

Cell Death Discovery
Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive.
Dongyun Wang, Yue Li, Guiying Li, Mengyu Liu, Zihui Zhou, Ming Wu, Shan Song, Yawei Bian, Jiajia Dong, Xinran Li, Yunxia Du, Tao Zhang, Yonghong Shi   +12 more
doaj   +1 more source

VDAC1 Intervention Alleviates Bisphenol AF-Induced Succinate Metabolism Dysregulation and Inflammatory Responses

Pharmaceuticals
Background/Objectives: Bisphenol AF (BPAF) is a prevalent environmental contaminant with demonstrated metabolic and immunological toxicity. This study aimed to investigate whether VDAC1 (Voltage-Dependent Anion Channel 1) mediates BPAF-induced succinate ...
Xinyu Hong, Ning Wang, Jing Leng, Jing Xu, Kelei Qian, Zhiqing Zheng, Gonghua Tao, Ping Xiao   +7 more
doaj   +1 more source

Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase

, 2009
The voltage-dependent anion channel (VDAC), located in the mitochondrial outer membrane, functions as gatekeeper for the entry and exit of mitochondrial metabolites, and thus controls cross-talk between mitochondria and the cytosol. VDAC also serves as a
Abu-Hamad, Salah, Shoshan-Barmatz, Varda, Zakar, Miri, Rosenthal, Keshet   +3 more
core   +1 more source

Visualizing VDAC1 in live cells using a tetracysteine tag

PLOS ONE
The voltage-dependent anion channel 1 (VDAC1) is a crucial gatekeeper in the outer mitochondrial membrane, controlling metabolic and energy homeostasis. The available methodological approaches fell short of accurate visualization of VDAC1 in living cells.
Johannes Pilic, Furkan E. Oflaz, Benjamin Gottschalk, Yusuf C. Erdogan, Wolfgang F. Graier, Roland Malli   +5 more
openaire   +2 more sources

Cox Regression analysis based on all patient data and VDAC1 expression.

, 2013
The influence VDAC1 and stage have on survival is evident from this figure with high VDAC1 expression inducing poor survival. VDAC1 is the most significant predictor of survival time with stage and pT also displaying predictive power.
Shu-Dong Zhang (231229), Jaine Blayney (356702), Puthen V. Jithesh (356701), Claire Grills (182684), Dean A. Fennell (111225)   +4 more
core   +1 more source

VDAC1 wt Allele [PDF]

, 2020
openaire   +1 more source

VDAC1 as Janus in cell death and survival : Annexin A5 to the rescue

VDAC1, a large conductance channel in the outer mitochondrial membrane, plays a crucial role in mitochondrial physiology. VDAC1 supports cellular metabolism and survival by serving as a mitochondrial $Ca^{2+}$-uptake and ATP-exit system.
Champion, Ophélie, Litewka, Jacek, Bultynck, Geert, Ferdek, Paweł   +3 more
core   +1 more source

The Native Conformation of the Human VDAC1 N Terminus

Angewandte Chemie International Edition, 2010
Schneider, R., Etzkorn, M., Giller, K., Daebel, V., Eisfeld, J., Zweckstetter, M., Griesinger, C., Becker, S., Lange, A.   +8 more
openaire   +4 more sources

Structure-based Analysis of VDAC1 Protein [PDF]

Journal of Biological Chemistry, 2012
Shay Geula, Hammad Naveed, Jie Liang, Varda Shoshan-Barmatz   +3 more
openaire   +1 more source

A single-vesicle fluorescence microscopy platform to quantify phospholipid scrambling. [PDF]

Nat Struct Mol Biol
Veit S, Dearden GI, Menon KM, Noor F, Menon I, Morizumi T, Ernst OP, Menon AK, Pomorski TG.   +8 more
europepmc   +1 more source