Results 121 to 130 of about 17,038 (231)

Decoding Cancer through Silencing the Mitochondrial Gatekeeper VDAC1

Biomolecules
Mitochondria serve as central hubs for regulating numerous cellular processes that include metabolism, apoptosis, cell cycle progression, proliferation, differentiation, epigenetics, immune signaling, and aging.
Tasleem Arif, Anna Shteinfer-Kuzmine, Varda Shoshan-Barmatz   +2 more
doaj   +1 more source

Ten Years of High Resolution Structural Research on the Voltage Dependent Anion Channel (VDAC)—Recent Developments and Future Directions [PDF]

, 2018
Mitochondria are evolutionarily related to Gram-negative bacteria and both comprise two membrane systems with strongly differing protein composition. The major protein in the outer membrane of mitochondria is the voltage-dependent anion channel (VDAC ...
Bausewein, Bay, Bayrhuber, Briones, Choudhary, Choudhary, Colombini, Fairman, Ge, Gonçalves, Grosse, Guo, Hiller, Hiller, Hosaka, Jaremko, Kutzner, Lackey, Lee, Lemasters, Mannella, Mertins, Neumann, Noskov, Noskov, Ott, Rostovtseva, Rui, Schredelseker, Shoshan-Barmatz, Shuvo, Ujwal, Villinger, Zachariae, Zeth   +34 more
core   +5 more sources

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

Ageing‐Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1‐Meditated Ca2+ Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice

Cell Proliferation, Volume 59, Issue 5, May 2026.
During skeletal muscle ageing, down‐regulation of TRα expression activates IP3R1 transcriptional expression, promotes MAM calcium transport, triggers mitochondrial calcium overload and apoptosis, leading to skeletal muscle atrophy. Restoring TRα expression can improve IP3R1‐mediated mitochondrial calcium overload and apoptosis in ageing skeletal muscle
Runqing Shi, Yusheng Zhang, Gong Chen, Jiru Zhang, Jing Liu, Hao Zhu, Minne Sun, Yu Duan   +7 more
wiley   +1 more source

Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis. [PDF]

, 2020
Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis.
Cuevas-Mora, Karina, Romero, Freddy, Roque, Willy   +2 more
core   +1 more source

ChREBP‐β Exacerbates Renal Tubular Disorders Caused by Fructose via ATF4

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Schematic diagram of the mechanism underlying fructose‐induced renal tubular injury via ChREBP‐β‐mediated disruption of endoplasmic reticulum and mitochondrial homeostasis. This diagram illustrates that fructose induces the transcriptional activation of ChREBP‐β, which subsequently triggers endoplasmic reticulum stress, disturbs inter‐organelle calcium
Ting Fang, Xinyu Yang, Xiaoqing Deng, Jingyi Wang, Ting Li, Hang Guo, Bei Sun, Liming Chen   +7 more
wiley   +1 more source

Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology [PDF]

, 2017
Anti-amyloid-β immunization leads to amyloid clearance in patients with Alzheimer's disease, but the effect of vaccination on amyloid-β-induced neuronal pathology has not been quantitatively examined.
Delisle, Marie-Bernadette, Ferrer, Isidro, Frosch, Matthew P., Growdon, John H., Hock, Christoph, Hyman, Bradley T., Masliah, Eliezer, Maurage, Claude-Alain, Nitsch, Roger M., Serrano-Pozo, Alberto, Uro-Coste, Emmanuelle, William, Christopher M.   +11 more
core  

VDAC1-interacting molecules promote cell death in cancer organoids through mitochondrial-dependent metabolic interference

iScience
Summary The voltage-dependent anion-selective channel isoform 1 (VDAC1) is a pivotal component in cellular metabolism and apoptosis with a prominent role in many cancer types, offering a unique therapeutic intervention point.
S. C. Nibali, S. de Siervi, Enrico Luchinat, Andrea Magrì, A. Messina, Lorenza Brocca, S. Mantovani, B. Oliviero, M. Mondelli, V. De Pinto, Cristian Turato, Cristina Arrigoni, Marco Lolicato   +12 more
semanticscholar   +1 more source

Selective induction of cancer cell death by VDAC1‐based peptides and their potential use in cancer therapy

Molecular Oncology, 2018
Mitochondrial VDAC1 mediates cross talk between the mitochondria and other parts of the cell by transporting anions, cations, ATP, Ca2+, and metabolites and serves as a key player in apoptosis.
Anna Shteinfer‐Kuzmine, Zohar Amsalem, Tasleem Arif, Alexandra Zooravlov, Varda Shoshan‐Barmatz   +4 more
doaj   +1 more source

LncRNA H19 inhibition impairs endoplasmic reticulum-mitochondria contact in hepatic cells and augments gluconeogenesis by increasing VDAC1 levels

Redox Biology
Inspite of exerting independent cellular functions, the endoplasmic-reticulum (ER) and the mitochondria also physically connect at specific sites termed mitochondria-associated ER membranes (MAMs) and these sites consist of several tethering proteins ...
Arun Nandwani, Shalu Rathore, Malabika Datta   +2 more
doaj   +1 more source