Results 31 to 40 of about 9,347 (172)
VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress
Cell Stress, 2017 This review presents current knowledge related to VDAC1 as a multi-functional mitochondrial protein acting on both sides of the coin, regulating cell life and death, and highlighting these functions in relation to disease. It is now recognized that VDAC1
Varda Shoshan-Barmatz +2 more
doaj +1 more source
Cells, 2019 Reprograming of the metabolism of cancer cells is an event recognized as a hallmark of the disease. The mitochondrial gatekeeper, voltage-dependent anion channel 1 (VDAC1), mediates transport of metabolites and ions in and out of mitochondria, and is ...
Tasleem Arif +4 more
doaj +1 more source
VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria [PDF]
Cell Death & Differentiation, 2011 Voltage-dependent anion channels (VDACs) are expressed in three isoforms, with common channeling properties and different roles in cell survival. We show that VDAC1 silencing potentiates apoptotic challenges, whereas VDAC2 has the opposite effect. Although all three VDAC isoforms are equivalent in allowing mitochondrial Ca(2+) loading upon agonist ...
Rizzuto, Rosario +6 more
openaire +6 more sources
Marine Drugs, 2016 Background: Hierridin B was isolated from a marine cyanobacterium Cyanobium sp. strain and induced cytotoxicity selectively in HT-29 adenocarcinoma cells. The underlying molecular mechanism was not yet elucidated. Methods: HT-29 cells were exposed to the
Sara Freitas +6 more
doaj +1 more source
VDAC1, mitochondrial dysfunction, and Alzheimer's disease
Pharmacological Research, 2018 Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have been implicated in the pathogenesis of AD, the etiology of the disease remains unclear.
Varda, Shoshan-Barmatz +3 more
openaire +2 more sources
Role of VDAC1 in hepatocyte apoptosis during acute liver injury in rats induced by obstructive jaundice [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Exploring the role of VDAC1 in hepatocyte apoptosis during acute liver injury induced by obstructive jaundice.Materials and Methods: Animal and cell models were established to investigate possible mechanisms during acute liver injury ...
Jinshan Liu +5 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 The mitochondrial voltage-dependent anion channel 1 (VDAC1) plays a central role in metabolism and apoptosis, which makes it a promising therapeutic target. Nevertheless, molecular mechanisms governing VDAC1 functioning remain unclear.
Hubert Gorny +5 more
doaj +1 more source
Silencing VDAC1 to Treat Mesothelioma Cancer: Tumor Reprograming and Altering Tumor Hallmarks
Biomolecules, 2022 Mesothelioma, an aggressive cancer with a poor prognosis, is linked to asbestos exposure. However, carbon nanotubes found in materials we are exposed to daily can cause mesothelioma cancer.
Swaroop Kumar Pandey +4 more
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Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics
Frontiers in Oncology, 2017 Cancer cells share several properties, high proliferation potential, reprogramed metabolism, and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key oncogenes and non-oncogenes essential for cancer cell survival and prosperity,
Varda Shoshan-Barmatz +3 more
doaj +1 more source
Voltage-Dependent Anion Channel 1 Expression in Oral Malignant and Premalignant Lesions
Diagnostics, 2023 Background: The voltage-dependent anion channel 1 protein (VDAC1) plays a role in cellular metabolism and survival. It was found to be down or upregulated (overexpressed) in different malignancies but it was never studied in application to oral lesions ...
Irit Allon +5 more
doaj +1 more source