Results 81 to 90 of about 9,347 (172)

Mitochondrial VDAC1-based peptides: Attacking oncogenic properties in glioblastoma

Oncotarget, 2017
Glioblastoma multiforme (GBM), a primary brain malignancy characterized by high morbidity, invasiveness, proliferation, relapse and mortality, is resistant to chemo- and radiotherapies and lacks effective treatment. GBM tumors undergo metabolic reprograming and develop anti-apoptotic defenses.
Shteinfer-Kuzmine, Anna, Arif, Tasleem, Krelin, Yakov, Tripathi, Shambhoo Sharan, Paul, Avijit, Shoshan-Barmatz, Varda   +5 more
openaire   +2 more sources

Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease

Neurobiology of Disease, 2014
Both the misfolding of α-synuclein and mitochondrial dysfunction are considered two major contributors to Parkinson's disease (PD). However, the relationship between the two in normal and PD states remains unclear.
Yaping Chu, Jennifer G. Goldman, Leo Kelly, Yinzhen He, Tracy Waliczek, Jeffrey H. Kordower   +5 more
doaj   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

Prediction and biological analysis of yeast VDAC1 phosphorylation

Archives of Biochemistry and Biophysics
The mitochondrial outer membrane protein porin 1 (Por1), the yeast orthologue of mammalian voltage-dependent anion channel (VDAC), is the major permeability pathway for the flux of metabolites and ions between cytosol and mitochondria. In yeast, several Por1 phosphorylation sites have been identified.
André D. Sousa, Ana Luisa Costa, Vítor Costa, Clara Pereira   +3 more
openaire   +2 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology
Etoposide is an inhibitor of DNA topoisomerase II, an enzyme essential for DNA transcription, replication, and chromosome segregation. It is well accepted that etoposide triggers cell death due to DNA damage.
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
doaj   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation

European Journal of Immunology, Volume 56, Issue 4, April 2026.
Inhaled pretreatment of mouse lungs with immunomodulatory Pam2ODN results in lung epithelial cell epigenetic reprogramming that is associated with attenuation of house dust mite extract (HDM)‐induced cDC2s and moDCs expansion in the lung, causing tolerance against HDM sensitization and restricting Th2‐cell‐induced airway eosinophilic allergic ...
Mbaya Ntita, Celine Shuet Lin Kong, Dalia Hassan, Richa Nayak, Jezreel Pantaleón García, Yongxing Wang, Jichao Chen, Scott E. Evans   +7 more
wiley   +1 more source

Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Barth syndrome (BTHS) is a rare X‐linked mitochondrial disorder caused by mutations in the TAFAZZIN gene, which disrupts cardiolipin (CL) remodelling and mitochondrial function. While cardiac manifestations of BTHS are well characterized in male patients, the mechanisms underlying skeletal muscle weakness and fatigability are poorly
Catalina Matias, Paige L. Snider, Elizabeth A. Sierra Potchanant, Joshua R. Huot, Rahul Raghav, Michael T. Chin, Simon J. Conway, Jeffrey J. Brault   +7 more
wiley   +1 more source

Role of Succinate Dehydrogenase in Age‐Related Th17 Inflammation

Aging Cell, Volume 25, Issue 4, April 2026.
Age‐induced mitoSTAT3‐dependent upregulation of mitochondrial complex II; succinate dehydrogenase (SDH), in CD4+ T cells promotes an imbalance in the levels of metabolites succinate and fumarate, characterized by lower succinate and higher fumarate. Changes in the metabolites alter mitochondrial structure and function and promote HIF1α to induce the ...
Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica‐Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath   +17 more
wiley   +1 more source

High‐Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting

Advanced Materials, Volume 38, Issue 16, 17 March 2026.
A DNA barcoding system enables high‐throughput in vivo screening of mitochondrial‐targeting gold nanoparticles. Thirty nanoparticle types with varied shapes, sizes, and ligands are individually barcoded and pooled. The pooled library is administered to tumor‐bearing mice, and barcodes retrieved from tumor mitochondria are amplified and sequenced to ...
Xingyue Huang, Xuehao Tian, Kuei Chen, Yang Wu, ChenCheng Xue, Yingjie Quek, Jessalyn Low, Arun Kumar, Andy Tay   +8 more
wiley   +1 more source