Results 251 to 260 of about 228,627 (303)

Role of Autotaxin in the Pathogenesis of Retina Ischemia and Its Therapeutic Implications. [PDF]

open access: yesInt J Mol Sci
Terao R   +9 more
europepmc   +1 more source

VEGFs, receptors and angiogenesis

Seminars in Cancer Biology, 1999
Angiogenesis, the formation of new blood vessels from pre--existing ones, is central for both normal development and homeostasis as well as in certain pathological conditions. The vascular endothelial growth factors (VEGFs) and their receptors are prime regulators of both physiological and pathological angiogenesis. The different VEGFs have overlapping
T, Veikkola, K, Alitalo
openaire   +2 more sources

Soluble VEGF receptors

Angiogenesis, 1999
The three human VEGF receptors 1-3 mediate biological signals important for new blood vessel formation and lymphangiogenesis. Soluble VEGF receptors contain all the information necessary for high affinity ligand binding and have been used as experimental tools and regulators in several angiogenic in vitro and in vivo models.
C, Hornig, H A, Weich
openaire   +2 more sources

VEGF and VEGF receptors are differentially expressed in chondrocytes

Bone, 2007
During long bone development, cartilage replacement by bone is governed in part by angiogenesis. Although it has been demonstrated that vascular endothelial growth factor (VEGF-A) is crucial during endochondral ossification, little is known about the involvement of the other VEGF family members.
Bluteau, G.   +6 more
openaire   +3 more sources

The biology of VEGF and its receptors

Nature Medicine, 2003
Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions.
Napoleone Ferrara, Hans-Peter Gerber
exaly   +3 more sources

VEGF receptor trafficking in angiogenesis

Biochemical Society Transactions, 2009
The intracellular trafficking of receptors provides a way to control the overall sensitivity of a cell to receptor stimulation. These sorting pathways are also used to shape the balance of signals that are generated in response to receptor activation.
Scott, Alice, Mellor, Harry
openaire   +3 more sources

Structure and function of VEGF receptors

IUBMB Life, 2009
AbstractVascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development and homeostasis. VEGFs are predominantly produced by endothelial, hematopoietic, and stromal cells in response to hypoxia and upon stimulation by growth factors such as transforming growth factor β (TGFβ), interleukins, or platelet‐derived growth factors
Stuttfeld E, Ballmer-Hofer K
openaire   +3 more sources

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