Results 261 to 270 of about 228,627 (303)

VEGF Receptor Signal Transduction

Science's STKE, 2001
The family of vascular endothelial growth factors (VEGFs) currently includes VEGF-A, -B, -C, -D, -E, and placenta growth factor (PlGF). Several of these factors, notably VEGF-A, exist as different isoforms, which appear to have unique biological functions.
T, Matsumoto, L, Claesson-Welsh
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VEGF-receptor signal transduction

Trends in Biochemical Sciences, 2003
The vascular endothelial growth factor (VEGF) family of ligands and receptors has been the focus of attention in vascular biology for more than a decade. There is now a consensus that the VEGFs are crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult.
Michael J, Cross, Johan, Dixelius, Taro, Matsumoto, Lena, Claesson-Welsh   +3 more
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VEGF and its receptors

International Congress Series, 2004
Abstract Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis. The biological effects of VEGF are mediated by two tyrosine kinase receptors, VEGFR-1 and VEGFR-2. T here is now compelling evidence that VEGF is implicated in pathological angiogenesis such as that occurring in cancer and intraocular neovascular ...
openaire   +1 more source

VEGF, its receptors and the Tie receptors in recurrent miscarriage [PDF]

Molecular Human Reproduction, 2000
The aetiology of recurrent miscarriage (at least three consecutive miscarriages) usually remains unsolved. The vascular endothelial growth factor (VEGF) family of proteins, together with their receptors and the Tie (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains) receptors, are crucial for embryonic development ...
P, Vuorela, O, Carpén, M, Tulppala, E, Halmesmäki   +3 more
exaly   +3 more sources

Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors

The FASEB Journal, 2006
ABSTRACT Lymphatic vascular development is regulated by vascular endothelial growth factor receptor‐3 (VEGFR‐3), which is activated by its ligands VEGF‐C and VEGF‐D. Neuropilin‐2 (NP2), known to be involved in neuronal development, has also been implicated to play a role in lymphangiogenesis. We aimed to elucidate
KÄRPÄNEN T, HECKMAN CA, KESKITALO S, JELTSCH M, OLLILA H, NEUFELD G, TAMAGNONE, Luca, ALITALO K.   +7 more
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Molecular Biology of the VEGF and the VEGF Receptor Family

Seminars in Thrombosis and Hemostasis, 2000
Vascular endothelial growth factor (VEGF) is the founding member of a still growing family of endothelial cell growth factors. The diverse functions of VEGF and its homologues (PIGF, VEGF-B, VEGF-C, VEGF-D, and VEGF-E) can be explained by their differential binding to the three signaling VEGF receptors.
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VEGF–VEGF receptor complexes as markers of tumor vascular endothelium

Journal of Controlled Release, 2001
Vascular endothelial growth factor (VEGF) is a primary stimulant of the vascularization of solid tumors and has therefore been the focus of intense research aimed at blocking its activity in solid tumors. VEGF production by tumor cells is induced by oncogenic gene mutations and hypoxic conditions inside the tumor mass.
R A, Brekken, P E, Thorpe
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Structure of a VEGF–VEGF receptor complex determined by electron microscopy

Nature Structural & Molecular Biology, 2007
Receptor tyrosine kinases are activated upon ligand-induced dimerization. Here we show that the monomeric extracellular domain of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) has a flexible structure. Binding of VEGF to membrane-distal immunoglobulin-like domains causes receptor dimerization and promotes further interaction between ...
Ruch C, Skiniotis G, Steinmetz MO, Walz T, Ballmer-Hofer K   +4 more
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Disease-specific expression of VEGF and its receptors in AML cells: possible autocrine pathway of VEGF/type1 receptor of VEGF in t(15;17) AML and VEGF/type2 receptor of VEGF in t(8;21) AML

Leukemia & Lymphoma, 2006
Various angiogenic factors, such as vascular endothelial growth factor (VEGF) and an associated molecule, placenta growth factor (PlGF), are thought to be important for normal and malignant hematopoiesis. This study examined mRNA expression of VEGF, PlGF and receptors for these molecules in AML cells and identified the disease-specific patterns of ...
A, Hiramatsu, H, Miwa, M, Shikami, T, Ikai, E, Tajima, H, Yamamoto, N, Imai, A, Hattori, T, Kyo, M, Watarai, K, Miura, A, Satoh, M, Itoh, A, Imamura, H, Mihara, Y, Katoh, M, Nitta   +16 more
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Gene expression for VEGF-A, VEGF-C, and their receptors in murine lymphocytes and macrophages

Biochemistry (Moscow), 2007
Vascular endothelial growth factors VEGF-A and VEGF-C are the main angiogenic factors that control growth of new blood and lymphatic vessels in the organism, and they also possess several immunoregulatory activities. Expression of VEGF-A and VEGF-C mRNA as well as mRNA for VEGF receptors in lymphocytes and macrophages of naive mice was investigated ...
Ekaterina Kisseleva
exaly   +3 more sources