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Pathophysiology and Prevention of Manual-Ventilation-Induced Lung Injury (MVILI) [PDF]

Pathophysiology
Manual ventilation, most commonly with a bag-valve mask, is a form of short-term ventilation used during resuscitative efforts in emergent and out-of-hospital scenarios.
Luke A. White, Steven A. Conrad, Jonathan Steven Alexander   +2 more
doaj   +4 more sources

Emerging concepts in ventilation-induced lung injury [version 1; peer review: 4 approved] [PDF]

F1000Research, 2020
Ventilation-induced lung injury results from mechanical stress and strain that occur during tidal ventilation in the susceptible lung. Classical descriptions of ventilation-induced lung injury have focused on harm from positive pressure ventilation ...
Purnema Madahar, Jeremy R. Beitler
doaj   +3 more sources

Ventilation-Induced Lung Injury (VILI) in Neonates: Evidence-Based Concepts and Lung-Protective Strategies. [PDF]

J Clin Med, 2022
Supportive care with mechanical ventilation continues to be an essential strategy for managing severe neonatal respiratory failure; however, it is well known to cause and accentuate neonatal lung injury. The pathogenesis of ventilator-induced lung injury
Kalikkot Thekkeveedu R, El-Saie A, Prakash V, Katakam L, Shivanna B.   +4 more
europepmc   +2 more sources

Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury. [PDF]

J Neuroinflammation, 2021
Background Mechanical ventilation of preterm newborns causes lung injury and is associated with poor neurodevelopmental outcomes. However, the mechanistic links between ventilation-induced lung injury (VILI) and brain injury is not well defined.
Chavez L, Meguro J, Chen S, de Paiva VN, Zambrano R, Eterno JM, Kumar R, Duncan MR, Benny M, Young KC, Dietrich WD, Brambilla R, Wu S, Schmidt AF.   +13 more
europepmc   +2 more sources

Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury? [PDF]

Am J Respir Crit Care Med, 2019
Many of the signaling pathways and growth factors involved with pulmonary fibrosis are well-described but little is known about why the fibroproliferative process progresses over time.
Albert RK, Smith B, Perlman CE, Schwartz DA.   +3 more
europepmc   +2 more sources

Salidroside Attenuates Ventilation Induced Lung Injury via SIRT1-Dependent Inhibition of NLRP3 Inflammasome

Cellular Physiology and Biochemistry, 2017
Background: Salidroside (SDS) is the main effective ingredient of Rhodiola rosea L with a variety of pharmacologic properties. We aim to investigate the effects of SDS on ventilation induced lung injury (VILI) and explore the possible underlying ...
Yan Wang, Chu-Fan Xu, Yu-Jian Liu, Yan-Fei Mao, Zhou Lv, Si-Yuan Li, Xiao-Yan Zhu, Lai Jiang   +7 more
doaj   +2 more sources

Exacerbation of Ventilation-Induced Lung Injury and Inflammation in Preterm Lambs by High-Dose Nanoparticles. [PDF]

Sci Rep, 2017
Mechanical ventilation of preterm neonates causes lung inflammation and injury, with potential life-long consequences. Inert 50-nm polystyrene nanoparticles (PS50G) reduce allergic inflammation in the lungs of adult mice.
Inocencio IM, Bischof RJ, Xiang SD, Zahra VA, Nguyen V, Lim T, LaRosa D, Barbuto J, Tolcos M, Plebanski M, Polglase GR, Moss TJ.   +11 more
europepmc   +2 more sources

Salidroside protects against ventilation-induced lung injury by inhibiting the expression of matrix metalloproteinase-9 [PDF]

Pharmaceutical Biology, 2021
Context Salidroside, a compound extracted from Rhodiola rosea L. (Crassulaceae), possesses many beneficial pathological effects. Objective To explore the effect of salidroside on ventilator-induced lung endothelial dysfunction in vivo and in vitro ...
Hui Zhang, Wenwen Dong, Siyuan Li, Yunqian Zhang, Zhou Lv, Lu Yang, Lai Jiang, Tao Wu, Yan Wang   +8 more
doaj   +2 more sources

Parecoxib reduced ventilation induced lung injury in acute respiratory distress syndrome. [PDF]

BMC Pharmacol Toxicol, 2017
Cyclooxygenase-2 (COX-2) contributes to ventilation induced lung injury (VILI) and acute respiratory distress syndrome (ARDS). The objective of present study was to observe the therapeutic effect of parecoxib on VILI in ARDS.
Meng FY, Gao W, Ju YN.
europepmc   +2 more sources

Autophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury

Frontiers in Immunology, 2020
Targeting inflammasome activation to modulate interleukin (IL)-1β is a promising treatment strategy against acute respiratory distress syndrome and ventilator-induced lung injury (VILI).
Kenichi Shimada, Timothy R Crother, Moshe Arditi   +2 more
exaly   +2 more sources