Results 31 to 40 of about 5,048,560 (285)

Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice [PDF]

, 2009
The study aim was to establish how recruitment maneuvers (RMs) influence lung mechanics and to determine whether RMs produce lung injury. Healthy BALB/c mice were allocated to receive positive end-expiratory pressure (PEEP) at 2 or 6 cmH2O and volume ...
Sly, P.D., Hantos, Z, Sly, Peter D., Berry, L.J., Turner, D.J., Zosky, G R, Cannizzaro, V; https://orcid.org/, Turner, Debra J., Hantos, Zoltan, Cannizzaro, V., Berry, Luke J., Nicholls, P.K., Hantos, Z., Nicholls, P K, Sly, P D, Zosk, G.R., Zosky, Graeme R., Berry, L J, Cannizzaro, Vincenzo, Nicholls, Phillip K., Turner, D J   +20 more
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The neuronal guidance protein netrin-1 reduces alveolar inflammation in a porcine model of acute lung injury [PDF]

, 2010
Introduction: Acute lung injury (ALI) is an inflammatory disorder of pulmonary or extrapulmonary origin. We have previously demonstrated that netrin-1 dampens murine ALI, and in an attempt to advance this finding into future clinical practice we ...
Kristina Waibler, Gabriele Nöldge-Schomburg, Rosenberger, Peter, Dierk A Vagts, Peter Rosenberger, Vagts, Dierk A., Klemens König, Thomas Iber, Christian Mutz, Westermann, Phillipp, Nöldge-Schomburg, Gabriele, Mutz, Christian, König, Klemens, Iber, Thomas, Valbona Mirakaj, Mirakaj, Valbona, Phillipp Westermann, Waibler, Kristina   +17 more
core   +1 more source

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
O'Kane, Cecilia M., O’Kane, Cecilia M., Laffey, John G, Cross, Mark, John G Laffey, McAuley, Daniel F; id_orcid, McNally, Christine, Michael Stevenson, Perkins, Gavin D., Crealey, Grainne, Laffey, John G., Daniel F McAuley, Murphy, Lynn, HASH(0x55a67ff73468), Stevenson, Michael, Cross, L. J. Mark, Grainne Crealey, Cecilia M O’Kane, McAuley, Daniel F., Mark Cross, null null, Gavin D Perkins, Perkins, Gavin D, Christine McNally, Lynn Murphy, O'Kane, Cecilia M, Cross Mark, Stevenson Michael, Murphy Lynn, McNally Christine, Crealey Grainne, Laffey John G, O’Kane Cecilia M, McAuley Daniel F, Perkins Gavin D   +34 more
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Independent lung ventilation in a newborn with asymmetric acute lung injury due to respiratory syncytial virus: a case report

Journal of Medical Case Reports, 2008
Introduction Independent lung ventilation is a form of protective ventilation strategy used in adult asymmetric acute lung injury, where the application of conventional mechanical ventilation can produce ventilator-induced lung injury and ventilation ...
Di Nardo Matteo, Perrotta Daniela, Stoppa Francesca, Cecchetti Corrado, Marano Marco, Pirozzi Nicola   +5 more
doaj   +1 more source

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium [PDF]

, 2013
Background: While acute lung injury (ALI) contributes significantly to critical illness, it resolves spontaneously in many instances. The majority of patients experiencing ALI require mechanical ventilation.
Christoph H Borchers, Michel Mittelbronn, Thomas Packard, Kominsky, Douglas J., Bonney, Megan, Packard, Thomas, Michel Mittelbronn (307400), Eltzschig, Holger K., Holger K Eltzschig, Kelley Brodsky (448211), Mariani, Thomas J., Borchers, Christoph H., Brodsky, Kelley, Christoph H. Borchers (159697), Thomas J. Mariani (11667), Han, Jun, Eckle, Tobias, Holger K. Eltzschig (37610), Mittelbronn, Michel Guy André, Megan Bonney (462424), Thomas J Mariani, Jun Han, Douglas J Kominsky, Douglas J. Kominsky (462426), Tobias Eckle, Jun Han (231645), Kelley Brodsky, Megan Bonney, Tobias Eckle (65757), Thomas Packard (462425)   +29 more
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Partial liquid ventilation improves lung function in ventilation-induced lung injury. [PDF]

European Respiratory Journal, 2001
Disturbances in lung function and lung mechanics are present after ventilation with high peak inspiratory pressures (PIP) and low levels of positive end-expiratory pressure (PEEP).
G. V. D. de Anda, R. A. Lachmann, S. Verbrugge, D. Gommers, J. J. Haitsma, B. Lachmann   +5 more
semanticscholar   +4 more sources

CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo [PDF]

, 2007
Background Bacterial DNA containing motifs of unmethylated CpG dinucleotides (CpG-ODN) initiate an innate immune response mediated by the pattern recognition receptor Toll-like receptor 9 (TLR9).
Schwederski Markus, Koch, Alexander, Schwederski, Markus, Ehrentraut Heidi, Baumgarten, Georg, Ehrentraut, Heidi, Hoeft, Andreas, Velten, Markus, Knüfermann, Pascal, Zacharowski Kai, Hoeft Andreas, Mersmann Jan, Knuefermann Pascal, Meyer Rainer, Grohé Christian, Baumgarten Georg, Zacharowski, Kai, Koch Alexander, Meyer, Rainer, Grohé, Christian, Velten Markus, Mersmann, Jan   +21 more
core   +1 more source

Mesenchymal Stem Cell Attenuates Neutrophil-predominant Inflammation and Acute Lung Injury in an In Vivo Rat Model of Ventilator-induced Lung Injury

Chinese Medical Journal, 2015
Background: Subsequent neutrophil (polymorphonuclear neutrophil [PMN])-predominant inflammatory response is a predominant feature of ventilator-induced lung injury (VILI), and mesenchymal stem cell (MSC) can improve mice survival model of endotoxin ...
Tian-Shun Lai, Zhi-Hong Wang, Shao-Xi Cai   +2 more
doaj   +1 more source

Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation. [PDF]

, 2012
Treatment of acute lung injury (ALI) remains an unsolved problem in intensive care medicine. As simvastatin exerts protective effects in inflammatory diseases we explored its effects on development of ALI and due to the importance of neutrophils in ALI ...
Vijayan, Santosh, Mörgelin Matthias, Grommes Jochen, Köppel, Thomas, Grommes, Jochen, Binneboesel, Marcel, Mörgelin, Matthias, Helene Hartwig (158829), Weber, Christian, Matthias Mörgelin (109607), Rolf Dembinski, Santosh Vijayan, Jochen Grommes (158815), Söhnlein, Oliver, Dembinski, Rolf, Drechsler, Maik, Thomas Andreas Koeppel, Oliver Soehnlein, Moergelin, Matthias, Vijayan Santosh, Dembinski Rolf, Weber Christian, Santosh Vijayan (158820), Koeppel, Thomas Andreas, Binnebösel, Marcel, Christian Weber (86566), Maik Drechsler (158824), Michael Jacobs, Maik Drechsler, Lund University., Rolf Dembinski (12675), Thomas Andreas Koeppel (158847), Koeppel Thomas Andreas, Marcel Binnebösel, Matthias Mörgelin, Jacobs, Michael, Jacobs Michael, Binnebösel Marcel, Oliver Soehnlein (158864), Michael Jacobs (105163), Hartwig Helene, Jochen Grommes, Mörgelin, Matthias,, Helene Hartwig, Marcel Binnebösel (158855), Soehnlein, Oliver, Hartwig, Helene, Drechsler Maik, Soehnlein Oliver, Christian Weber   +49 more
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From state-of-the-art ventilation to closed loop ventilation

, 2022
Recent emphasis on energy load delivered during each ventilatory breath has opened a new insight to reduce harmful ventilatory induced lung injury, but no robust clinical evidence of patient benefit produced yet. Closed loop ventilation is a strategy to
Andreas Schibler, van der Staay, Matthias, Schibler, Andreas, Matthias van der Staay, Remus, Christian, Christian Remus   +5 more
core   +1 more source