Results 21 to 30 of about 5,048,560 (285)

Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model. [PDF]

PLoS ONE, 2017
Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury.
Laura A Cagle, Lisa M Franzi, Angela L Linderholm, Jerold A Last, Jason Y Adams, Richart W Harper, Nicholas J Kenyon   +6 more
doaj   +1 more source

Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration. [PDF]

PLoS ONE, 2015
BACKGROUND:Ventilator-induced lung injury is a form of acute lung injury that develops in critically ill patients on mechanical ventilation and has a high degree of mortality. Nicotinamide phosphoribosyltransferase is an enzyme that is highly upregulated
Heather D Jones, Jeena Yoo, Timothy R Crother, Pierre Kyme, Anat Ben-Shlomo, Ramtin Khalafi, Ching W Tseng, William C Parks, Moshe Arditi, George Y Liu, Kenichi Shimada   +10 more
doaj   +1 more source

A Peptide Inhibitor of Peroxiredoxin 6 Phospholipase A₂ Activity Significantly Protects against Lung Injury in a Mouse Model of Ventilator Induced Lung Injury (VILI)

Antioxidants, 2021
Ventilator induced lung injury (VILI) is a lung injury syndrome associated with mechanical ventilation, most frequently for treatment of Acute Lung Injury (ALI), and generally secondary to the use of greater than physiologic tidal volumes.
Aron B. Fisher, Chandra Dodia, Shampa Chatterjee   +2 more
doaj   +1 more source

Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]

PLoS ONE, 2008
Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay, Wei Wu, Naftali Kaminski, Emeka Ifedigbo, A Murat Kaynar, Mária Szilasi, Simon C Watkins, Stefan W Ryter, Alexander Hoetzel, Augustine M K Choi   +9 more
doaj   +1 more source

Mesalazine-induced lung injury with severe respiratory failure successfully treated with steroids and non-invasive positive pressure ventilation

Respiratory Medicine Case Reports, 2020
Drug-induced lung injury (DLI) has become more common because of the increasing number of therapeutic agents in use. Mesalazine, also known as 5-aminosalicylic acid (5-ASA), is one of the key drugs for the treatment of ulcerative colitis (UC).
Hajime Oi, Atsushi Suzuki, Yasuhiko Yamano, Toshiki Yokoyama, Toshiaki Matsuda, Kensuke Kataoka, Yasuhiko Suzuki, Tomoki Kimura, Yasuhiro Kondoh   +8 more
doaj   +1 more source

Spontaneous breathing promotes lung injury in an experimental model of alveolar collapse

Scientific Reports, 2022
Vigorous spontaneous breathing has emerged as a promotor of lung damage in acute lung injury, an entity known as “patient self-inflicted lung injury”. Mechanical ventilation may prevent this second injury by decreasing intrathoracic pressure swings and ...
María Consuelo Bachmann, Pablo Cruces, Franco Díaz, Vanessa Oviedo, Mariela Goich, José Fuenzalida, Luis Felipe Damiani, Roque Basoalto, Yorschua Jalil, David Carpio, Niki Hamidi Vadeghani, Rodrigo Cornejo, Maximiliano Rovegno, Guillermo Bugedo, Alejandro Bruhn, Jaime Retamal   +15 more
doaj   +1 more source

High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury

Journal of Intensive Care, 2023
Background Mechanical ventilation may cause pulmonary hypertension in patients with acute lung injury (ALI), but the underlying mechanism remains elucidated.
Yonghao Xu, Yu Zhang, Jie Zhang, Weibo Liang, Ya Wang, Zitao Zeng, Zhenting Liang, Zhaoyi Ling, Yubiao Chen, Xiumei Deng, Yongbo Huang, Xiaoqing Liu, Haibo Zhang, Yimin Li   +13 more
doaj   +1 more source

High tidal volume ventilation is not deleterious in infant rats exposed to severe hemorrhage [PDF]

, 2010
BACKGROUND: Both high tidal volume (VT) ventilation and hemorrhage induce acute lung injury in adult rodents. It is not known whether injurious ventilation augments lung injury in infant rats exposed to severe hemorrhage.
Nicholls, Philip K., Sly, P.D., Hantos, Z, Sly, Peter D., Berry, L.J., Cannizzaro, V; https://orcid.org/, Hantos, Zoltán, Cannizzaro, V., Berry, Luke J., Nicholls, P.K., Hantos, Z., Nicholls, P K, Sly, P D, Berry, L J, Cannizzaro, Vincenzo   +14 more
core   +1 more source

Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury. [PDF]

PLoS ONE, 2018
Mechanical ventilation is a life-saving clinical treatment but it can induce or aggravate lung injury. New therapeutic strategies, aimed at reducing the negative effects of mechanical ventilation such as excessive production of reactive oxygen species ...
Julie Wagner, Karl M Strosing, Sashko G Spassov, Ziwei Lin, Helen Engelstaedter, Sabine Tacke, Alexander Hoetzel, Simone Faller   +7 more
doaj   +1 more source

Quantifying Regional Lung Deformation Using Four-Dimensional Computed Tomography: A Comparison of Conventional and Oscillatory Ventilation

Frontiers in Physiology, 2020
Mechanical ventilation strategies that reduce the heterogeneity of regional lung stress and strain may reduce the risk of ventilator-induced lung injury (VILI). In this study, we used registration of four-dimensional computed tomographic (4DCT) images to
Jacob Herrmann, Jacob Herrmann, Jacob Herrmann, Sarah E. Gerard, Wei Shao, Monica L. Hawley, Joseph M. Reinhardt, Joseph M. Reinhardt, Gary E. Christensen, Gary E. Christensen, Eric A. Hoffman, Eric A. Hoffman, Eric A. Hoffman, David W. Kaczka, David W. Kaczka, David W. Kaczka, David W. Kaczka   +16 more
doaj   +1 more source