Results 141 to 150 of about 8,038 (173)
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Versican in Health and Disease
Connective Tissue Research, 2008Versican is a component of the extracellular matrix, which interacts with several matrix and cell surface molecules. Versican plays central roles in tissue morphogenesis and homeostasis and is implicated in the development of numerous diseases. The expression of versican by multiple cell types is differentially regulated in a temporal and spatial ...
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Aggrecan and versican: two brothers close or apart
American Journal of Physiology-Cell Physiology, 2022Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix. They share the same structural domains at both N- and C-termini. The N-terminal G1 domain binds hyaluronan (HA), forms an HA-rich matrix, and regulates HA-mediated signaling.
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Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair
CirculationBACKGROUND: The adult mammalian heart is incapable of regeneration, whereas a transient regenerative capacity is maintained in the neonatal heart, primarily through the proliferation of preexisting cardiomyocytes. Neonatal heart regeneration after myocardial injury is accompanied by an expansion of cardiac fibroblasts and ...
qianqian yin, Haotong Li, Bin Zhou
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T-cell responses to versican in ankylosing spondylitis
Rheumatology International, 2009The objective of our study was to undertake a systematic analysis of the T-cell response to the proteoglycan versican G1-globular domain (VG1) in ankylosing spondylitis (AS) as immunity to VG1 in mice can induce a pathology closely resembling AS. Peripheral blood lymphocytes from 36 AS patients and 33 healthy controls were incubated with recombinant ...
Tae-Jong, Kim +5 more
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Versican: Role in Cancer Tumorigenesis
2017Versican is an extracellular matrix proteoglycan that is expressed in a wide variety of cancers. Several cellular sources for versican have been identified in a multitude of cancers including tumor cells, stromal cells, myeloid cells, and lymphoid cells.
Paul A. Keire +2 more
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Perspectives on developmental neurobiology, 1997
Proteoglycans have long been recognized as participating in a number of biological activities ranging from structural roles to regulation of transcription. Versican is a large chondroitin sulfate proteoglycan expressed in several tissues, including the nervous system.
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Proteoglycans have long been recognized as participating in a number of biological activities ranging from structural roles to regulation of transcription. Versican is a large chondroitin sulfate proteoglycan expressed in several tissues, including the nervous system.
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Versican protects cells from oxidative stress-induced apoptosis
Matrix Biology, 2005Oxidant injury plays a critical role in the degenerative changes that are characterized by a decline in parenchymal cell numbers and viability, and occur with aging and in the etiology of many diseases. The extracellular proteoglycan versican is widely distributed in the extracellular matrix surrounding the cells.
Yaojiong, Wu +7 more
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Hyaluronan, CD44 and versican in epidermal keratinocyte tumours
British Journal of Dermatology, 2003The high molecular weight polysaccharide hyaluronan is a major component of the extracellular matrix between the vital cells of human skin epidermis. The levels of hyaluronan, and those of the hyaluronan receptor CD44 and the hyaluronan binding proteoglycan versican, correlate with the aggressiveness of different human carcinomas of epithelial origin ...
S, Karvinen +3 more
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Glycosaminoglycan and versican deposits in taxane-induced sclerosis
British Journal of Dermatology, 2015Docetaxel and paclitaxel are widely used in the treatment of various malignant neoplasms. Taxane-induced sclerosis is dose-dependent and usually not generalized. Little information on the pathogenesis of scleroderma is currently available. Here, we report a case of generalized scleroderma and a case of early-stage oedematous sclerosis, both of which ...
K. Okada +5 more
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Atherosclerosis, 2001
Abdominal aortic aneurysm (AAA) is a common disease of human aorta with increased incidence. It is a complication to atherosclerosis and it is closely associated with alterations in extracellular macromolecules. In this study, the levels of mRNA for versican--the major extracellular arterial proteoglycan (PG)--present in AAA and normal aortas were ...
A D, Theocharis +3 more
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Abdominal aortic aneurysm (AAA) is a common disease of human aorta with increased incidence. It is a complication to atherosclerosis and it is closely associated with alterations in extracellular macromolecules. In this study, the levels of mRNA for versican--the major extracellular arterial proteoglycan (PG)--present in AAA and normal aortas were ...
A D, Theocharis +3 more
openaire +2 more sources