Results 211 to 220 of about 6,573 (255)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Rapid screening of very long-chain fatty acids from microorganisms

Journal of Chromatography A, 2019
The analysis of triacylglycerols and phospholipids - phosphatidylcholines allowed the use of shotgun lipidomics to identify very long-chain fatty acids and very long-chain polyunsaturated fatty acids in microalgae. These fatty acids were determined in triacylglycerols by positive electrospray ionization of neutral loss scans of different fatty acids, e.
Tomáš Řezanka, Milada Vítová, Jaromir Lukavský   +2 more
exaly   +3 more sources

Enantiomeric separation of triacylglycerols containing very long chain fatty acids

Journal of Chromatography A, 2018
Enantiomers of triacylglycerols (TAGs) containing any combination of very long chain fatty acids (VLCFAs) and/or very long chain polyunsaturated fatty acids (VLCPUFAs) with diolein, dilinolein and didocosahexaenoin were synthesized. Gradient non-aqueous reversed-phase high-performance liquid chromatography/high resolution atmospheric pressure chemical ...
Tomáš Řezanka, Linda Nedbalová, Karel Sigler   +2 more
exaly   +4 more sources

Very long chain fatty acids

Progress in Lipid Research, 2022
Very long chain fatty acids (VLCFAs) are important components of various lipid classes in most organisms, from bacteria to higher plants and mammals, including humans. VLCFAs, or very long chain polyunsaturated fatty acids (VLCPUFAs), can be defined as fatty acids with 23 or more carbon atoms in the molecule.
Kyselová, L., Vítová, M. (Milada), Řezanka, T. (Tomáš)   +2 more
openaire   +3 more sources

Very long-chain fatty acids in Rett syndrome

European Journal of Pediatrics, 1999
Rett syndrome (RS), found exclusively in girls, is characterised by a global deceleration of psychomotor development, loss of acquired speech, loss of manual skills and subsequent deceleration of head growth. The cause of this syndrome is so far unknown.
T J, Stradomska, A, Tylki-Szymańska, Z, Bentkowski   +2 more
openaire   +2 more sources

Very long chain fatty acid oxidation in rat liver

Biochemical and Biophysical Research Communications, 1981
Abstract [l- 14 C]Lignoceric acid (C24:0) was oxidized to CO 2 and water-soluble intermediates by rat liver preparations. With mitochondria alone, the radioactivity in the water-soluble material increased rapidly for the first 10 min, then decreased, while 14 CO 2 appeared only after the 10 min lag.
N, Kawamura, H W, Moser, Y, Kishimoto
openaire   +2 more sources

Nutritional Significance and Metabolism of Very Long Chain Fatty Alcohols and Acids from Dietary Waxes

Experimental Biology and Medicine, 2004
Very long chain fatty alcohols obtained from plant waxes and beeswax have been reported to lower plasma cholesterol in humans. This review discusses nutritional or regulatory effects produced by wax esters or aliphatic acids and alcohols found in ...
James L Hargrove, Phillip Greenspan, Diane K Hartle   +2 more
exaly   +2 more sources

Very Long-Chain Fatty Acids in Peroxisomal Disease

1992
Fatty acids with from 24 to 28 carbon atoms (very long-chain fatty acids, VLCFA) are present in small amounts in all mammalian tissues. Even longer chain fatty acids with from 30 to 38 carbon atoms (ultra-long-chain fatty acids, ULCFA) are found in certain specialized tissues including retina, brain, and spermatozoa.
A, Poulos, K, Beckman, D W, Johnson, B C, Paton, B S, Robinson, P, Sharp, S, Usher, H, Singh   +7 more
openaire   +2 more sources

Extending the story of very-long-chain fatty acid elongation

Plant Science, 2013
Very-long-chain fatty acids (VLCFAs) are essential molecules produced by all plant cells, and are components or precursors of numerous specialized metabolites synthesized in specific cell types. VLCFAs are elongated by an endoplasmic reticulum-localized fatty acid elongation complex of four core enzymes, which sequentially add two carbon units to a ...
Tegan M, Haslam, Ljerka, Kunst
openaire   +2 more sources