Results 201 to 210 of about 144,497 (249)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis [PDF]

Cell Chemical Biology, 2017
Necroptosis is a form of regulated cell death that is linked to various human diseases. Distinct membrane-related, thus lipid-dependent, alterations take place during necroptosis. However, little is known about the roles of specific lipids in this process. We used an untargeted LC-MS-based approach to reveal that distinct lipid species are regulated at
Nasi Li, Güneş Ekin Atilla-Gökçümen, Laura R. Parisi   +2 more
exaly   +3 more sources

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Very long chain fatty acids

Progress in Lipid Research, 2022
Very long chain fatty acids (VLCFAs) are important components of various lipid classes in most organisms, from bacteria to higher plants and mammals, including humans. VLCFAs, or very long chain polyunsaturated fatty acids (VLCPUFAs), can be defined as fatty acids with 23 or more carbon atoms in the molecule.
Kyselová, L., Vítová, M. (Milada), Řezanka, T. (Tomáš)   +2 more
openaire   +3 more sources

Very long-chain fatty acids in Rett syndrome

European Journal of Pediatrics, 1999
Rett syndrome (RS), found exclusively in girls, is characterised by a global deceleration of psychomotor development, loss of acquired speech, loss of manual skills and subsequent deceleration of head growth. The cause of this syndrome is so far unknown.
T J, Stradomska, A, Tylki-Szymańska, Z, Bentkowski   +2 more
openaire   +2 more sources

Rapid screening of very long-chain fatty acids from microorganisms

Journal of Chromatography A, 2019
The analysis of triacylglycerols and phospholipids - phosphatidylcholines allowed the use of shotgun lipidomics to identify very long-chain fatty acids and very long-chain polyunsaturated fatty acids in microalgae. These fatty acids were determined in triacylglycerols by positive electrospray ionization of neutral loss scans of different fatty acids, e.
Milada Vítová, Irena Jarošová, Tomáš Řezanka   +2 more
exaly   +3 more sources

Very Long-Chain Fatty Acids in Peroxisomal Disease

1992
Fatty acids with from 24 to 28 carbon atoms (very long-chain fatty acids, VLCFA) are present in small amounts in all mammalian tissues. Even longer chain fatty acids with from 30 to 38 carbon atoms (ultra-long-chain fatty acids, ULCFA) are found in certain specialized tissues including retina, brain, and spermatozoa.
A, Poulos, K, Beckman, D W, Johnson, B C, Paton, B S, Robinson, P, Sharp, S, Usher, H, Singh   +7 more
openaire   +2 more sources

Extending the story of very-long-chain fatty acid elongation

Plant Science, 2013
Very-long-chain fatty acids (VLCFAs) are essential molecules produced by all plant cells, and are components or precursors of numerous specialized metabolites synthesized in specific cell types. VLCFAs are elongated by an endoplasmic reticulum-localized fatty acid elongation complex of four core enzymes, which sequentially add two carbon units to a ...
Tegan M, Haslam, Ljerka, Kunst
openaire   +2 more sources

Very long chain fatty acid oxidation in rat liver

Biochemical and Biophysical Research Communications, 1981
Abstract [l- 14 C]Lignoceric acid (C24:0) was oxidized to CO 2 and water-soluble intermediates by rat liver preparations. With mitochondria alone, the radioactivity in the water-soluble material increased rapidly for the first 10 min, then decreased, while 14 CO 2 appeared only after the 10 min lag.
N, Kawamura, H W, Moser, Y, Kishimoto
openaire   +2 more sources