Membrane fusion activity of vesicular stomatitis virus glycoprotein G is induced by low pH but not by heat or denaturant [PDF]
, 2003 The fusogenic envelope glycoprotein G of the rhabdovirus vesicular stomatitis virus (VSV) induces membrane fusion at acidic pH. At acidic pH the G protein undergoes a major structural reorganization leading to the fusogenic conformation.
Epand, Raquel F +4 more
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USE OF REAL-TIME qRT-PCR FOR FMD VIRUS DETECTION IN CATTLE MILK
Ветеринария сегодня, 2019 FMDV can be shed with milk of infected animals and infect susceptible animals. The possibility of using real-time qRT-PCR for FMD virus detection in cattle milk was assessed. To prepare samples of FMDV infected milk the following strains were used: А No.
A. M. Timina +2 more
doaj +1 more source
Phenotypic lentivirus screens to identify functional single domain antibodies [PDF]
, 2016 Manipulation of proteins is key in assessing their in vivo function. Although genetic ablation is straightforward, reversible and specific perturbation of protein function remains a challenge.
Brewer, Rebeccah +6 more
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Single-cycle viral gene expression, rather than progressive replication and oncolysis, is required for VSV therapy of B16 melanoma [PDF]
, 2010 A fully intact immune system would be expected to hinder the efficacy of oncolytic virotherapy by inhibiting viral replication. Simultaneously, however, it may also enhance antitumor therapy through initiation of proinflammatory, antiviral cytokine ...
Barber, G +7 more
core +1 more source
Plasma Membrane Phosphatidylinositol 4,5 Bisphosphate Is Required for Internalization of Foot-and-Mouth Disease Virus and Vesicular Stomatitis Virus [PDF]
, 2015 Phosphatidylinositol-4,5-bisphosphate, PI(4,5)P 2, is a phospholipid which plays important roles in clathrin-mediated endocytosis. To investigate the possible role of this lipid on viral entry, two viruses important for animal health were selected: the ...
Martín-Acebes, Miguel Ángel +2 more
core +2 more sources
Coronins and their role in immunological phenomena
Central European Journal of Immunology, 2017 Coronins are a large family of proteins occurring in many eukaryotes. In mammals, seven coronin genes have been identified, evidencing that coronins 1 to 6 present classic coronin structure, while coronin 7 is a tandem coronin particle, without a spiral ...
Beata Tokarz-Deptuła +3 more
doaj +1 more source
Human ACE2 Genetic Polymorphism Affecting SARS-CoV and SARS-CoV-2 Entry into Cells
Microbiology Spectrum, 2022 Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 have a single envelope glycoprotein (S protein) that binds to human angiotensin-converting enzyme 2 (ACE2) on the host cell membrane.
Takanari Hattori +7 more
doaj +1 more source
Malpais spring virus is a new species in the genus vesiculovirus [PDF]
, 2013 BACKGROUND: Malpais Spring virus (MSPV) is a mosquito-borne rhabdovirus that infects a variety of wild and feral ungulates in New Mexico, including horses and deer. Although, initial serologic tests and electron microscopy at the time of isolation nearly
Amelia PA Travassos da Rosa +6 more
core +1 more source
Molecular Mechanisms Underlying the Cellular Entry and Host Range Restriction of Lujo Virus
mBio, 2022 Like other human-pathogenic arenaviruses, Lujo virus (LUJV) is a causative agent of viral hemorrhagic fever in humans. LUJV infects humans with high mortality rates, but the susceptibilities of other animal species and the molecular determinants of its ...
Takeshi Saito +6 more
doaj +1 more source
Senecavirus A in Pigs, United States, 2015 [PDF]
, 2016 Citation: Hause, B. M., Myers, O., Duff, J., & Hesse, R. A. (2016). Senecavirus A in Pigs, United States, 2015. Emerging Infectious Diseases, 22(7), 1323-1325.
Duff, J. +3 more
core +2 more sources