Results 1 to 10 of about 54,876 (184)

Molecular recognition requires dimerization of a VHH antibody

mAbs, 2023
Camelid heavy-chain-only antibodies are a unique class of antibody that possesses only a single variable domain (termed VHH) for antigen recognition.
Christopher A. Smith, Gregory J. Sonneson, Robert J. Hoey, Jennifer M. Hinerman, Kimberly Sheehy, Richard Walter, Andrew B. Herr, James R. Horn   +7 more
doaj   +3 more sources

Bispecific single-domain antibody (VHH) fused with human IgG1 Fc with dual specificity effectively neutralize Naja Kaouthia venom. [PDF]

PLoS Neglected Tropical Diseases
Naja kaouthia, or the monocled cobra, is one of the most medically important snakes in Thailand, responsible for approximately 17% of snakebite cases. Conventional horse-derived antivenoms are lifesaving, yet they may trigger severe allergic reactions ...
Kanokporn Pothisamutyothin, Sirisak Sathorn, Ratchana Boonmee, Wichit Thaveekarn, Wanatchaporn Arunmanee   +4 more
doaj   +2 more sources

Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection [PDF]

Frontiers in Immunology, 2019
Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A.
Dorien De Vlieger, Dorien De Vlieger, Dorien De Vlieger, Katja Hoffmann, Inge Van Molle, Inge Van Molle, Wim Nerinckx, Wim Nerinckx, Lien Van Hoecke, Lien Van Hoecke, Marlies Ballegeer, Marlies Ballegeer, Marlies Ballegeer, Sarah Creytens, Sarah Creytens, Sarah Creytens, Han Remaut, Han Remaut, Hartmut Hengel, Bert Schepens, Bert Schepens, Xavier Saelens, Xavier Saelens, Xavier Saelens   +23 more
doaj   +3 more sources

VHH Antibodies: Reagents for Mycotoxin Detection in Food Products [PDF]

Sensors, 2018
Mycotoxins are the toxic secondary metabolites produced by fungi and they are a worldwide public health concern. A VHH antibody (or nanobody) is the smallest antigen binding entity and is produced by heavy chain only antibodies.
Jia Wang, Hina Mukhtar, Lan Ma, Qian Pang, Xiaohong Wang   +4 more
doaj   +3 more sources

Complete Neutralization of Tetanus Neurotoxin by Alpaca-Derived Trivalent Nanobodies Aimed at Veterinary Medical Applications [PDF]

Veterinary Sciences
Tetanus is a zoonotic disease posing significant threats to both humans and animals, particularly horses, sheep, and ruminants. Current antitoxin therapies rely on animal-derived immunoglobulins, presenting challenges including animal welfare concerns ...
Chiyomi Sakamoto, Chie Shitada, Norihiko Kiyose, Nobuo Miyazaki, Sena Kamesawa, Hiroshi Morioka, Kazunori Morokuma, Kazuhiko Tomokiyo, Motohide Takahashi   +8 more
doaj   +2 more sources

VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models [PDF]

Frontiers in Immunology
BackgroundPancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a 5-year survival rate below 10%, largely due to late-stage diagnosis and the limited effectiveness of conventional therapies such as surgery, chemotherapy, and ...
Ying Xing, Ying Xing, Gangqiang Shi, Zhengli Li, Xiancheng Liu, Linghu Nie, Yu Zhang, Yiqin Song, Shilin Sun, Mike K. S. Chan, Mike K. S. Chan, Mike K. S. Chan, Mike K. S. Chan, Michelle B. F. Wong, Michelle B. F. Wong, Krista Casazza, Jonathan R. T. Lakey, Jonathan R. T. Lakey, Yuping Chen, Xuekai Zhu, Yunfeng Feng   +20 more
doaj   +2 more sources

From discovery to the clinic: structural insights, engineering options, clinical, and ‘next wave’ applications of camelid-derived single-domain antibodies [PDF]

mAbs
Camelid-derived single domain antibodies (sdAbs), referred to as VHHs (variable domains of the heavy chain of a heavy chain-only antibodies), recently emerged as promising building blocks for the construction of therapeutic molecules. As of October 2025,
Andreas Evers, Enrico Guarnera, Lukas Pekar, Stefan Zielonka   +3 more
doaj   +2 more sources

Molecular docking study and mapping the binding site of some antiviral nanobodies against receptor binding domain (RBD) of SARS-COV 2 [PDF]

Nanochemistry Research, 2021
Neutralization ability of some antiviral nanobodies was computed against the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2).
zahra pahlavan, Mohammad Hossein Fatemi
doaj   +1 more source

VHH characterization.Recombinant VHHs: Production, characterization and affinity [PDF]

Analytical Biochemistry, 2020
Among the biological approaches to therapeutics, are the cells, such as CAR-T cells engineered or not, the antibodies armed or not, and the smaller protein scaffolds that can be modified to render them specific of other proteins, à la façon of antibodies.
Chabrol, Eric, Stojko, Johann, Nicolas, Alexandre, Botzanowski, Thomas, Fould, Benjamin, Antoine, Mathias, Cianférani, Sarah, Ferry, Gilles, Boutin, Jean, A.   +8 more
openaire   +3 more sources

Construction of a Humanized Artificial VHH Library Reproducing Structural Features of Camelid VHHs for Therapeutics [PDF]

Antibodies, 2022
A variable domain of heavy chain antibody (VHH) has different binding properties than conventional antibodies. Conventional antibodies prefer binding to the convex portion of the antigen, whereas VHHs prefer epitopes, such as crevices and clefts on the antigen.
Taihei Murakami, Shigefumi Kumachi, Yasuhiro Matsunaga, Miwa Sato, Kanako Wakabayashi-Nakao, Hidekazu Masaki, Ryo Yonehara, Maiko Motohashi, Naoto Nemoto, Masayuki Tsuchiya   +9 more
openaire   +3 more sources