Results 1 to 10 of about 54,904 (251)

VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models [PDF]

Frontiers in Immunology
BackgroundPancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a 5-year survival rate below 10%, largely due to late-stage diagnosis and the limited effectiveness of conventional therapies such as surgery, chemotherapy, and ...
Ying Xing, Ying Xing, Gangqiang Shi, Zhengli Li, Xiancheng Liu, Linghu Nie, Yu Zhang, Yiqin Song, Shilin Sun, Mike K. S. Chan, Mike K. S. Chan, Mike K. S. Chan, Mike K. S. Chan, Michelle B. F. Wong, Michelle B. F. Wong, Krista Casazza, Jonathan R. T. Lakey, Jonathan R. T. Lakey, Yuping Chen, Xuekai Zhu, Yunfeng Feng   +20 more
doaj   +3 more sources

Development of VHH antibodies against dengue virus type 2 NS1 and comparison with monoclonal antibodies for use in immunological diagnosis. [PDF]

PLoS ONE, 2014
The possibility of using variable domain heavy-chain antibodies (VHH antibodies) as diagnostic tools for dengue virus (DENV) type 2 NS1 protein was investigated and compared with the use of conventional monoclonal antibodies.
Aneela Fatima, Haiying Wang, Keren Kang, Liliang Xia, Ying Wang, Wei Ye, Jufang Wang, Xiaoning Wang   +7 more
doaj   +3 more sources

Molecular recognition requires dimerization of a VHH antibody

mAbs, 2023
Camelid heavy-chain-only antibodies are a unique class of antibody that possesses only a single variable domain (termed VHH) for antigen recognition.
Christopher A. Smith, Gregory J. Sonneson, Robert J. Hoey, Jennifer M. Hinerman, Kimberly Sheehy, Richard Walter, Andrew B. Herr, James R. Horn   +7 more
doaj   +3 more sources

Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. [PDF]

PLoS ONE, 2011
For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Virus (
Anna Hultberg, Nigel J Temperton, Valérie Rosseels, Mireille Koenders, Maria Gonzalez-Pajuelo, Bert Schepens, Lorena Itatí Ibañez, Peter Vanlandschoot, Joris Schillemans, Michael Saunders, Robin A Weiss, Xavier Saelens, José A Melero, C Theo Verrips, Steven Van Gucht, Hans J de Haard   +15 more
doaj   +10 more sources

Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection [PDF]

Frontiers in Immunology, 2019
Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A.
Dorien De Vlieger, Dorien De Vlieger, Dorien De Vlieger, Katja Hoffmann, Inge Van Molle, Inge Van Molle, Wim Nerinckx, Wim Nerinckx, Lien Van Hoecke, Lien Van Hoecke, Marlies Ballegeer, Marlies Ballegeer, Marlies Ballegeer, Sarah Creytens, Sarah Creytens, Sarah Creytens, Han Remaut, Han Remaut, Hartmut Hengel, Bert Schepens, Bert Schepens, Xavier Saelens, Xavier Saelens, Xavier Saelens   +23 more
doaj   +3 more sources

From discovery to the clinic: structural insights, engineering options, clinical, and ‘next wave’ applications of camelid-derived single-domain antibodies [PDF]

mAbs
Camelid-derived single domain antibodies (sdAbs), referred to as VHHs (variable domains of the heavy chain of a heavy chain-only antibodies), recently emerged as promising building blocks for the construction of therapeutic molecules. As of October 2025,
Andreas Evers, Enrico Guarnera, Lukas Pekar, Stefan Zielonka   +3 more
doaj   +2 more sources

Molecular docking study and mapping the binding site of some antiviral nanobodies against receptor binding domain (RBD) of SARS-COV 2 [PDF]

Nanochemistry Research, 2021
Neutralization ability of some antiviral nanobodies was computed against the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2).
zahra pahlavan, Mohammad Hossein Fatemi
doaj   +1 more source

Immunogenicity of single-chain antibodies: germlining of a VHH lowers T-cell activation from epitopes in FR2 and CDR regions. [PDF]

MAbs
Giraudet R, Laroche A, Chalopin B, Dubois S, Correia E, Staropoli I, Schwartz O, Maillère B, Nozach H.   +8 more
europepmc   +2 more sources

Selection of single domain anti-transferrin receptor antibodies for blood-brain barrier transcytosis using a neurotensin based assay and histological assessment of target engagement in a mouse model of Alzheimer’s related amyloid-beta pathology

PLoS ONE, 2022
The blood-brain barrier (BBB) presents a major obstacle in developing specific diagnostic imaging agents for many neurological disorders. In this study we aimed to generate single domain anti-mouse transferrin receptor antibodies (anti-mTfR VHHs) to ...
Shiran Su, Thomas J. Esparza, David L. Brody   +2 more
doaj   +2 more sources

Development of Antibody-Fragment–Producing Rice for Neutralization of Human Norovirus

Frontiers in Plant Science, 2021
Human norovirus is the leading cause of acute nonbacterial gastroenteritis in people of all ages worldwide. Currently, no licensed norovirus vaccine, pharmaceutical drug, or therapy is available for the control of norovirus infection.
Ai Sasou, Yoshikazu Yuki, Yoshikazu Yuki, Shiho Kurokawa, Shintaro Sato, Shintaro Sato, Shintaro Sato, Yuki Goda, Masao Uchida, Naomi Matsumoto, Hiroshi Sagara, Yuji Watanabe, Masaharu Kuroda, Naomi Sakon, Kotomi Sugiura, Rika Nakahashi-Ouchida, Rika Nakahashi-Ouchida, Hiroshi Ushijima, Kohtaro Fujihashi, Kohtaro Fujihashi, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono   +23 more
doaj   +1 more source