Results 161 to 170 of about 42,252 (217)

A neuraminidase-targeted nanobody confers broad protection against influenza B virus. [PDF]

J Virol
Jia H, Lin C, Guo Y, Cai W, Guan R, Zhu L, Yang Q, Kong H, Sun B, Zhang Z, Ma J.   +10 more
europepmc   +1 more source

An RNA-to-RNA pipeline for rapid antiviral antibody development. [PDF]

Mol Ther
Hodge EA, Archer J, Anderson JS, Warner NL, Tremblay J, Klose T, Park S, Hinkley T, Khandhar AP, Kuhn R, Shoemaker CB, Erasmus JH.   +11 more
europepmc   +1 more source

Nanobody-based analysis of RhoGTPase stress response in <i>Schizosaccharomyces pombe</i>: Role of <i>mtl</i>2. [PDF]

Biotechnol Rep (Amst)
Rasheed N, Ali X, Ali T, Muhammad F, Rasheed MA.   +4 more
europepmc   +1 more source

Relationship Between Hospital Volume and Outcomes of Minimally Invasive Esophagectomy for Esophageal Cancer: Analysis of the National Clinical Database in Japan. [PDF]

Ann Gastroenterol Surg
Ozawa S, Kumamaru H, Kitagawa Y, Koyanagi K, Oguma J, Udagawa H, Miyata H, Toh Y, Matsubara H.   +8 more
europepmc   +1 more source

Characterization of the VHH-Fc construct rimteravimab in healthy adults and patients hospitalized for mild-to-moderate COVID-19: Two Phase 1 randomized clinical trials. [PDF]

PLoS Med
Jansen E, Bockstal V, Herschke F, Olsson Gisleskog P, Rinaldi M, Boerboom A, Hadi S, Gaibu N, Moutschen M, Tersago D.   +9 more
europepmc   +1 more source

Applications of VHH in cancer diagnosis and therapy

openaire   +2 more sources

VHH characterization. Comparison of recombinant with chemically synthesized anti-HER2 VHH [PDF]

Protein Science, 2019
AbstractIn the continuous exploration of the VHH chemistry, biochemistry and therapeutic future use, we investigated two different production strategies of this small antibody‐like protein, using an anti‐HER2 VHH as a model. The total chemical synthesis of the 125 amino‐acid peptide was performed with reasonable yield, even if optimization will be ...
Thomas Botzanowski, Renaud Wagner, Jean A Boutin   +2 more
exaly   +6 more sources

VHH antibodies: emerging reagents for the analysis of environmental chemicals [PDF]

Analytical and Bioanalytical Chemistry, 2016
A VHH antibody (or nanobody) is the antigen binding fragment of heavy chain only antibodies. Discovered nearly 25 years ago, they have been investigated for their use in clinical therapeutics and immunodiagnostics, and more recently for ...
Candace S Bever, Zhen-Lin Xu, Natalia Vasylieva   +2 more
exaly   +2 more sources

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Expression of VHHs in Saccharomyces cerevisiae

2012
The production of VHHs in microorganisms is relatively straightforward, however the amount of VHH produced per volume unit can vary substantially from hardly detectable to hundreds of milligrams per liter. Expression in Escherichia coli is more commonly used at initial research phase, since production of VHHs for large-scale application in E.
Andrea, Gorlani, Hans, de Haard, Theo, Verrips   +2 more
openaire   +2 more sources

Selection of VHHs Under Application Conditions

2012
The successful application of antibody fragments such as VHHs in diagnostic assays, affinity purification, imaging, or therapy is not determined by the specificity and affinity of the antibody fragment alone. The ability to bind the target protein in the environment in which the antibody fragment is intended to functionally perform determines to a ...
Dolk, E., Verrips, C.T., de Haard, J.J.W.   +2 more
openaire   +3 more sources