Results 171 to 180 of about 41,395 (219)

Atomically accurate de novo design of antibodies with RFdiffusion. [PDF]

Nature
Bennett NR, Watson JL, Ragotte RJ, Borst AJ, See DL, Weidle C, Biswas R, Yu Y, Shrock EL, Ault R, Leung PJY, Huang B, Goreshnik I, Tam J, Carr KD, Singer B, Criswell C, Wicky BIM, Vafeados D, Garcia Sanchez M, Kim HM, Vázquez Torres S, Chan S, Sun SM, Spear TT, Sun Y, O'Reilly K, Maris JM, Sgourakis NG, Melnyk RA, Liu CC, Baker D.   +31 more
europepmc   +1 more source

Applications of VHH in cancer diagnosis and therapy

openaire   +2 more sources

VHH characterization. Comparison of recombinant with chemically synthesized anti‐HER2 VHH [PDF]

Protein Science, 2019
AbstractIn the continuous exploration of the VHH chemistry, biochemistry and therapeutic future use, we investigated two different production strategies of this small antibody‐like protein, using an anti‐HER2 VHH as a model. The total chemical synthesis of the 125 amino‐acid peptide was performed with reasonable yield, even if optimization will be ...
Gabrielle Zeder-Lutz, Gilles Ferry, Renaud Wagner   +2 more
exaly   +5 more sources

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Construction of Synthetic VHH Libraries in Ribosome Display Format.

Methods in molecular biology, 2023
Single-domain antibodies, or VHH, represent an attractive molecular basis to design affinity proteins with favorable properties. Beyond high affinity and specificity for their cognate target, they usually show high stability and high production yields in bacteria, yeast, or mammalian cells.
Audrey Guilbaud, F. Pecorari
semanticscholar   +5 more sources

Abstract 4103: The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

Cancer Research, 2023
Heterogeneous antigen expression is a key barrier influencing the activity of chimeric antigen receptor (CAR) T cells in solid tumors. Here, we developed CAR T cells targeting glypican-1 (GPC1), an oncofetal antigen expressed in pancreatic cancer.
Nan Li, Alex Quan, Dan Li, Hua Ren, Weiming Ni, Jing Zhou, R. Cachau, Mitchell Ho   +7 more
semanticscholar   +1 more source

VHH antibodies: emerging reagents for the analysis of environmental chemicals [PDF]

Analytical and Bioanalytical Chemistry, 2016
A VHH antibody (or nanobody) is the antigen binding fragment of heavy chain only antibodies. Discovered nearly 25 years ago, they have been investigated for their use in clinical therapeutics and immunodiagnostics, and more recently for environmental monitoring applications.
Candace S Bever, Jie-Xian Dong, Natalia Vasylieva   +2 more
exaly   +5 more sources

A High-affinity and specificity anti-HER2 single-domain antibody (VHH) that targets trastuzumab’s epitope with versatile biochemical, biological, and medical applications

Immunologic research, 2023
In the past decade, various single-domain antibodies from llamas, also known as VHH or nanobody, have been discovered with applications in tumor imaging and cancer therapy.
S. K. Nikkhoi, Hediyeh Heydarzadeh, V. Vandavasi, Ge Yang, Pedro Louro, M. Polunas, Hajar Owji, A. Hatefi   +7 more
semanticscholar   +1 more source

Ultrasensitive and rapid colorimetric detection of paraquat via a high specific VHH nanobody.

Biosensors & bioelectronics, 2022
Rapid and quantitative detection of paraquat is crucial because of its high toxicity. Here, we developed an ultrasensitive time-resolved fluorescence immunochromatographic assay (TRFICA) strip based on our synthesized variable domain of heavy chain ...
Yongyi Zhang, Li-hua Li, Yu Wang, Hong Wang, Zhenlin Xu, Yuan-Xin Tian, Yuan-ming Sun, Jinyi Yang, Yu-Dong Shen   +8 more
semanticscholar   +1 more source