Results 11 to 20 of about 57,494 (245)
Characterization of plant produced VHH antibodies against cobra venom toxins for antivenom therapy
Biotechnology ReportsCobra (Naja kaouthia) venom contains many toxins including α-neurotoxin (αNTX) and phospholipase A2 (PLA2), which can cause neurodegeneration, respiratory failure, and even death.
Sarocha Vitayathikornnasak +8 more
doaj +2 more sources
International Journal of Molecular SciencesCAR-T cell therapy is at the forefront of next-generation multiple myeloma (MM) management, with two B-cell maturation antigen (BCMA)-targeted products recently approved. However, these products are incapable of breaking the infamous pattern of patient relapse.
Heleen Hanssens +7 more
openaire +4 more sources
International Immunology, 2022 Abstract Antigen-combining sites of the camelid heavy-chain antibody variable domain (VHH) are constructed by three complementarity-determining regions (CDR1, CDR2 and CDR3). We prepared cDNA using mRNA extracted from peripheral lymphocytes of alpacas that had been non-immunized or immunized with human serum albumin (HSA).
Narutoshi Tsukahara +7 more
openaire +3 more sources
PLoS ONE, 2022 The blood-brain barrier (BBB) presents a major obstacle in developing specific diagnostic imaging agents for many neurological disorders. In this study we aimed to generate single domain anti-mouse transferrin receptor antibodies (anti-mTfR VHHs) to ...
Shiran Su +2 more
doaj +2 more sources
AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized Alpaca for Predicting Antigen-Antibody Interactions [PDF]
Neural Information Processing Systems, 2023 Antibodies have become an important class of therapeutic agents to treat human diseases. To accelerate therapeutic antibody discovery, computational methods, especially machine learning, have attracted considerable interest for predicting specific ...
Hirofumi Tsuruta +10 more
semanticscholar +1 more source
Development of Antibody-Fragment–Producing Rice for Neutralization of Human Norovirus
Frontiers in Plant Science, 2021 Human norovirus is the leading cause of acute nonbacterial gastroenteritis in people of all ages worldwide. Currently, no licensed norovirus vaccine, pharmaceutical drug, or therapy is available for the control of norovirus infection.
Ai Sasou +23 more
doaj +1 more source
VHH characterization. Comparison of recombinant with chemically synthesized anti‐HER2 VHH [PDF]
Protein Science, 2019 AbstractIn the continuous exploration of the VHH chemistry, biochemistry and therapeutic future use, we investigated two different production strategies of this small antibody‐like protein, using an anti‐HER2 VHH as a model. The total chemical synthesis of the 125 amino‐acid peptide was performed with reasonable yield, even if optimization will be ...
Lucie Hartmann +14 more
openaire +4 more sources
The Dynamics of Vowel Hypo- and Hyperarticulation in Swedish Infant-Directed Speech to 12-Month-Olds
Frontiers in Communication, 2020 Vowel hypo- and hyperarticulation (VHH) was investigated in Swedish infant-directed speech (IDS) to Swedish 12-month-olds using a measure that normalizes across speakers and vowels: the vhh-index. The vhh-index gives the degree of VHH for each individual
Ellen Marklund, Lisa Gustavsson
doaj +1 more source
Recombinant monovalent llama-derived antibody fragments (VHH) to rotavirus VP6 protect neonatal gnotobiotic piglets against human rotavirus-induced diarrhea [PDF]
, 2013 Group A Rotavirus (RVA) is the leading cause of severe diarrhea in children. The aims of the present study were to determine the neutralizing activity of VP6-specific llama-derived single domain nanoantibodies (VHH nanoAbs) against different RVA strains ...
Alvarado, Carmen +14 more
core +10 more sources
Frontiers in Immunology, 2023 Background Chimeric antigen receptor (CAR)-T cell therapy has established itself as a potent therapeutic option for certain patients with relapsed/refractory (R/R) hematologic malignancies.
F. Nasiri +2 more
semanticscholar +1 more source