Results 21 to 30 of about 54,904 (251)
Scientific Reports, 2022 PCSK9 is an effective target for lowering LDL-c. Previously, a camelid-human chimeric heavy chain antibody VHH-B11-Fc targeting human PCSK9 was designed. It had a potent hypolipidemic effect.
Xinyang Li +4 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Diabetic nephropathy the main reason for end stage renal disease is a common microvascular complication in patients with type 1 and type 2 diabetes. The interleukin-6 (IL-6), acting as a pleiotropic cytokine, play key roles in main autoimmune disorders ...
Nanwen Zhang +12 more
doaj +1 more source
Isolation of Novel EGFR-Specific VHH Domains [PDF]
SLAS Discovery, 2009 Epidermal growth factor receptor (EGFR) is overexpressed or mutated in a high percentage of tumors. EGFR has long been considered a promising target for cancer diagnostic and therapeutic applications. However, monoclonal antibodies and other large antibody constructs diffuse into tumors slowly, limiting their efficacy. To develop lower molecular weight
Elizabeth B, Gottlin +5 more
openaire +2 more sources
Llama nanoantibodies with therapeutic potential against human norovirus diarrhea. [PDF]
PLoS ONE, 2015 Noroviruses are a major cause of acute gastroenteritis, but no vaccines or therapeutic drugs are available. Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa with several advantages ...
Lorena Garaicoechea +8 more
doaj +1 more source
Lactobacillli expressing llama VHH fragments neutralise Lactococcusphages [PDF]
BMC Biotechnology, 2007 Abstract Background Bacteriophages infecting lactic acid bacteria (LAB) are widely acknowledged as the main cause of milk fermentation failures. In this study, we describe the surface-expression as well as the secretion of two functional llama heavy-chain antibody fragments, one binding to the major capsid protein ...
Moineau Sylvain +6 more
openaire +3 more sources
Peptide Linker Affecting the Activity Retention Rate of VHH in Immunosorbents
Biomolecules, 2020 VHH-based immunosorbents are an emerging and promising tool for the removal of toxic substances from plasma. However, the small size of VHHs is a double-edged sword, bringing both benefits and drawbacks to the immunosorbent.
Da Li +5 more
doaj +1 more source
Single-domain antibodies and their formatting to combat viral infections [PDF]
, 2018 Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies +4 more
core +2 more sources
VHH production at the high-luminosity LHC [PDF]
The European Physical Journal Plus, 2019 14 pages, 8 figures, 4 ...
Karl Nordström, Andreas Papaefstathiou
openaire +4 more sources
Biotechnology & Biotechnological Equipment, 2021 Antibodies are key elements in routine immunological tests, having a long history in detection of plant pathogens due to their specificity, reliability and fast performance.
Faith Njeri Njeru, Paul Mbogo Kusolwa
doaj +1 more source
mAbs, 2022 Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the ...
Desislava Yanakieva +9 more
doaj +1 more source