Results 31 to 40 of about 54,904 (251)
Discrete analysis of camelid variable domains: sequences, structures, and in-silico structure prediction [PDF]
PeerJ, 2020 Antigen binding by antibodies requires precise orientation of the complementarity- determining region (CDR) loops in the variable domain to establish the correct contact surface.
Akhila Melarkode Vattekatte +9 more
doaj +2 more sources
Intracellular VHHs to monitor and modulate GPCR signaling
Frontiers in Endocrinology, 2022 Single-domain antibody fragments, also known as VHHs or nanobodies, have opened promising avenues in therapeutics and in exploration of intracellular processes. Because of their unique structural properties, they can reach cryptic regions in their cognate antigen.
Pauline Raynaud +9 more
openaire +5 more sources
Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
Frontiers in Molecular Biosciences, 2022 The human genome encodes 850 G protein-coupled receptors (GPCRs), half of which are considered potential drug targets. GPCRs transduce extracellular stimuli into a plethora of vital physiological processes. Consequently, GPCRs are an attractive drug target class.
Toon Laeremans +10 more
openaire +3 more sources
Frontiers in Immunology, 2017 The activity of tumor necrosis factor (TNF), a cytokine involved in inflammatory pathologies, can be inhibited by antibodies or trap molecules. Herein, llama-derived variable heavy-chain domains of heavy-chain antibody (VHH, also called Nanobodies™) were
Els Beirnaert +14 more
doaj +1 more source
VHHs as tools for therapeutic protein delivery to the central nervous system
Fluids and Barriers of the CNS, 2022 Background The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a biologically active neuropeptide ...
Yessica Wouters +5 more
doaj +1 more source
Lactobacilli as a Vector for Delivery of Nanobodies against Norovirus Infection
Pharmaceutics, 2022 Passive administration of neutralizing antibodies (Abs) is an attractive strategy for the control of gastrointestinal infections. However, an unanswered practical concern is the need to assure the stability of sufficient amounts of orally administered ...
Yoshikazu Yuki +8 more
doaj +1 more source
Market-induced Asset Specificity: Redefining the Hold-up Problem [PDF]
, 2004 In a standard hold-up problem, individuals are vulnerable to hold-up because it is impossible to write complete contracts to cover the lifespan of relationship-specific investments.
Lewin-Solomons, Shira
core +1 more source
Advances in Therapeutic Antibody Discovery and Development Targeting G Protein-Coupled Receptors. [PDF]
Pharmacol Res PerspectABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Hutchings CJ +6 more
europepmc +2 more sources
A tetraspecific VHH-based neutralizing antibody modifies disease outcome in three animal models of Clostridium difficile infection [PDF]
, 2016 Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia.
Beamer, Gillian +12 more
core +2 more sources
On the Interaction of Monetary and Fiscal Policy [PDF]
, 2003 In this paper we review some fundamental issues that have been identified by macroeconomists in discussing the co-ordination of monetary and fiscal policy.
Chadha, Jagjit S., Nolan, Charles
core +1 more source