Results 31 to 40 of about 57,494 (245)
Llama nanoantibodies with therapeutic potential against human norovirus diarrhea. [PDF]
PLoS ONE, 2015 Noroviruses are a major cause of acute gastroenteritis, but no vaccines or therapeutic drugs are available. Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa with several advantages ...
Lorena Garaicoechea +8 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Diabetic nephropathy the main reason for end stage renal disease is a common microvascular complication in patients with type 1 and type 2 diabetes. The interleukin-6 (IL-6), acting as a pleiotropic cytokine, play key roles in main autoimmune disorders ...
Nanwen Zhang +12 more
doaj +1 more source
VHH-Based Bispecific Antibodies Targeting Cytokine Production [PDF]
Frontiers in Immunology, 2017 Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because proinflammatory cytokines possess non-redundant protective and immunoregulatory functions, their systemic neutralization carries the potential for unwanted side effects.
Maxim A. Nosenko +18 more
openaire +3 more sources
VHH CDR-H3 conformation is determined by VH germline usage
Communications Biology, 2023 VHHs or nanobodies are single antigen binding domains originating from camelid heavy-chain antibodies. They are used as diagnostic and research tools and in a variety of therapeutic molecules. Analyzing variable domain structures from llama and alpaca we
Zahra Bahrami Dizicheh +2 more
semanticscholar +1 more source
Biotechnology & Biotechnological Equipment, 2021 Antibodies are key elements in routine immunological tests, having a long history in detection of plant pathogens due to their specificity, reliability and fast performance.
Faith Njeri Njeru, Paul Mbogo Kusolwa
doaj +1 more source
Single-domain antibodies and their formatting to combat viral infections [PDF]
, 2018 Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies +4 more
core +2 more sources
VHH production at the high-luminosity LHC [PDF]
The European Physical Journal Plus, 2019 14 pages, 8 figures, 4 ...
Karl Nordström, Andreas Papaefstathiou
openaire +4 more sources
Materials Today Chemistry, 2023 SARS-CoV-2 rapid spread required urgent, accurate, and prompt diagnosis to control the virus dissemination and pandemic management. Several sensors were developed using different biorecognition elements to obtain high specificity and sensitivity. However,
A. Santos +17 more
semanticscholar +1 more source
mAbs, 2022 Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the ...
Desislava Yanakieva +9 more
doaj +1 more source
Structural Basis of MERS‐CoV Receptor Interactions and Antibody Neutralisations [PDF]
Rev Med VirolABSTRACT Increasing outbreaks of coronaviruses underscore the importance of antivirals and vaccines that can combat a wide range of coronaviruses. Neutralising antibodies (nAbs), along with vaccines and small‐molecule drugs, are among the most promising treatments and prevention options against coronaviruses.
Gavor E +5 more
europepmc +2 more sources