Results 51 to 60 of about 57,494 (245)
A tetraspecific VHH-based neutralizing antibody modifies disease outcome in three animal models of Clostridium difficile infection [PDF]
, 2016 Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia.
Beamer, Gillian +12 more
core +2 more sources
FULLY AI-DRIVEN HUMANOID VHH PHAGE LIBRARY
Antibody Therapeutics, 2023 Abstract Background & Significance VHHs are small and stable fragments that have great potential as therapeutics due to their small size, stability, versatility, and potential for oral administration.
Zhao, Yangyang +9 more
openaire +1 more source
Large-Scale Production of Anti-RNase A VHH Expressed in pyrG Auxotrophic Aspergillus oryzae
Current Issues in Molecular Biology, 2023 Nanobodies, also referred to as VHH antibodies, are the smallest fragments of naturally produced camelid antibodies and are ideal affinity reagents due to their remarkable properties.
E. Karaman +3 more
semanticscholar +1 more source
Lactobacilli as a Vector for Delivery of Nanobodies against Norovirus Infection
Pharmaceutics, 2022 Passive administration of neutralizing antibodies (Abs) is an attractive strategy for the control of gastrointestinal infections. However, an unanswered practical concern is the need to assure the stability of sufficient amounts of orally administered ...
Yoshikazu Yuki +8 more
doaj +1 more source
Market-induced Asset Specificity: Redefining the Hold-up Problem [PDF]
, 2004 In a standard hold-up problem, individuals are vulnerable to hold-up because it is impossible to write complete contracts to cover the lifespan of relationship-specific investments.
Lewin-Solomons, Shira
core +1 more source
Evaluation of the Potential Impact of In Silico Humanization on VHH Dynamics
International Journal of Molecular Sciences, 2023 Camelids have the peculiarity of having classical antibodies composed of heavy and light chains as well as single-chain antibodies. They have lost their light chains and one heavy-chain domain.
Carla Martins +3 more
semanticscholar +1 more source
Scientific Reports, 2018 Nucleolin arises as a relevant target for cancer therapy, as it is overexpressed at the surface of cancer and angiogenic endothelial cells thus enabling a dual cellular targeting strategy.
Sofia Romano +4 more
doaj +1 more source
Unions: Rent Extractors or Creators? [PDF]
, 2004 Unions: Rent Extractors or ...
Aidt, Toke S., Sena, Vania
core +1 more source
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model
EMBO Molecular Medicine, 2022 Single domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders.
Marika Marino +22 more
semanticscholar +1 more source
Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies
mAbs, 2021 The respiratory virus responsible for coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected nearly every aspect of life worldwide, claiming the lives of over 3.9 million people globally, at the ...
Maxwell A. Stefan +15 more
doaj +1 more source