Results 61 to 70 of about 57,494 (245)

Self-Assembling VHH-Elastin-Like Peptides for Photodynamic Nanomedicine [PDF]

Biomacromolecules, 2017
Recombinant llama heavy-chain antibody fragments (VHHs) are promising tools in the field of targeted nanomedicine. 7D12, a VHH against the epidermal growth factor receptor (EGFR) that is overexpressed in various cancers, has been evaluated as an effective cancer-targeting VHH in multiple studies.
Pille, J., van Lith, S.A.M., van Hest, J., van Hest, J., Leenders, W.P.J.   +4 more
openaire   +5 more sources

Orally active bivalent VHH construct prevents proliferation of F4+ enterotoxigenic Escherichia coli in weaned piglets

iScience, 2022
Summary A major challenge in industrial pig production is the prevalence of post-weaning diarrhea (PWD) in piglets, often caused by enterotoxigenic Escherichia coli (ETEC).
B. K. Fiil, S. Thrane, Michael Pichler, Tiia Kittilä, Line Ledsgaard, Shirin Ahmadi, G. M. Maigaard Hermansen, L. Jelsbak, C. Lauridsen, S. Brix, A. H. Laustsen   +10 more
semanticscholar   +1 more source

Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3

Protein Science, 2022
The camelid single domain antibody, referred to VHH or Nanobody, is considered a versatile tool for various biotechnological and clinical applications because of its favorable biophysical properties. To take advantage of these characteristics and for its
Seisho Kinoshita, Makoto Nakakido, Chinatsu Mori, Daisuke Kuroda, J. Caaveiro, K. Tsumoto   +5 more
semanticscholar   +1 more source

Design Digestion: work in progress [PDF]

, 2008
Enough of taste and mastication. It is time to look beyond the momentary, tasteful consumption of designed objects, in order to make account of the various meanings that are generated through their more drawn-out engagements.
Booth, Peter, Brassett, Jamie
core   +1 more source

Highly potent multivalent VHH antibodies against Chikungunya isolated from an alpaca naïve phage display library

Journal of Nanobiotechnology, 2022
Background Chikungunya virus (CHIKV) is a re-emerged mosquito-borne alphavirus that can cause musculoskeletal diseases, imposing a substantial threat to public health globally.
Qianlin Li, Fuqiang Zhang, Yi Lu, Huan Hu, Jin Wang, Cheng Guo, Q. Deng, Conghui Liao, Qin Wu, T. Hu, Zeliang Chen, Jiahai Lu   +11 more
semanticscholar   +1 more source

Contribution of CDR3 in characterization of camelid VHH and its aflatoxin B1-binding interaction

Food Chemistry Advances
The single variable domain of heavy chain (VHH) antibodies, owing to their unique properties, has gained attention in immunoassays. However, compared with macromolecule antigens, in the case of small molecule haptens, such as aflatoxin B1 (AFB1), the ...
Hina Mukhtar, Lan Ma, Qian Pang, Xiaohong Wang, Jia Wang   +4 more
doaj   +1 more source

Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions

mAbs
The development of bispecific antibodies that bind at least two different targets relies on bringing together multiple binding domains with different binding properties and biophysical characteristics to produce a drug-like therapeutic.
Michael J. Mullin, James McClory, W. Haynes, Justin Grace, Nathan J. Robertson, G. van Heeke   +5 more
semanticscholar   +1 more source

First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variants

Scientific Reports, 2022
SARS-CoV-2 and its variants have persisted in this ongoing COVID-19 pandemic. While the vaccines have greatly reduced the COVID-19 cases, hospitalizations, and death, about half of the world remain unvaccinated due to various reasons.
Allison Titong, Sachith Gallolu Kankanamalage, Jianbo Dong, Betty C. B. Huang, Nicholas Spadoni, Bo Wang, M. Wright, Keegan L. J. Pham, Anh Hai Le, Yue Liu   +9 more
semanticscholar   +1 more source

VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins [PDF]

, 2015
Peer reviewedPublisher ...
Clem, Flajnik, Makrides, Marchalonis, Müller   +4 more
core   +3 more sources

Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure

Nature Communications, 2022
The dysregulated physical interaction between two intracellular membrane proteins, the sarco/endoplasmic reticulum Ca2+ ATPase and its reversible inhibitor phospholamban, induces heart failure by inhibiting calcium cycling.
Erwin De Genst, K. Foo, Yao Xiao, Eduarde Rohner, Emma de Vries, Jesper Sohlmér, Nevin Witman, A. Hidalgo, Terje R. Kolstad, W. Louch, S. Pehrsson, A. Park, Y. Ikeda, Xidan Li, L. Mayr, K. Wickson, K. Jennbacken, Ken-Inge Hansson, R. Fritsche-Danielson, James Hunt, K. Chien   +20 more
semanticscholar   +1 more source