Results 111 to 120 of about 188,914 (350)

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Vimentin regulates mitochondrial ROS production and inflammatory responses of neutrophils

Frontiers in Immunology
The intermediate filament vimentin is present in immune cells and is implicated in proinflammatory immune responses. Whether and how it supports antimicrobial activities of neutrophils are not well established.
Thao Ngoc Huynh, Jody Toperzer, Allison Scherer, Allison Scherer, Anne Gumina, Tonya Brunetti, Michael K. Mansour, Michael K. Mansour, David M. Markovitz, Brian C. Russo   +9 more
doaj   +1 more source

Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes

Cells, 2019
Vimentin (VIM) is an intermediate filament (nanofilament) protein expressed in multiple cell types, including astrocytes. Mice with VIM mutations of serine sites phosphorylated during mitosis (VIMSA/SA) show cytokinetic failure in fibroblasts and lens ...
Yolanda de Pablo, Pavel Marasek, Andrea Pozo-Rodrigálvarez, Ulrika Wilhelmsson, Masaki Inagaki, Marcela Pekna, Milos Pekny   +6 more
doaj   +1 more source

The 68,000-Dalton Neurofilament-Associated Polypeptide is a Component of Nonneuronal Cells and of Skeletal Myofibrils [PDF]

, 1980
Purified preparations of 10-nm neurofilaments from rat spinal cord and bovine or porcine brain contain a predominant 68,000-dalton polypeptide. This polypeptide is also a major component of the neurofilaments that copurify with brain tubulin isolated by ...
Asai, David J., Lazarides, Elias, Wang, Chung   +2 more
core  

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Magnetic resonance and computed tomography imaging of a carotid body tumor in a dog [PDF]

, 2012
A 5-year-old castrated male Labrador Retriever was presented to a referring veterinarian for a swelling in the neck region. Based on the results of histopathology, a carotid body tumor, was diagnosed.
De Cock, Hilde, Gielen, Ingrid, Kromhout, Kaatje, van Bree, Henri, Van Dyck, Kristof   +4 more
core   +2 more sources

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Nonlinear Elasticity in Biological Gels [PDF]

, 2004
Unlike most synthetic materials, biological materials often stiffen as they are deformed. This nonlinear elastic response, critical for the physiological function of some tissues, has been documented since at least the 19th century, but the molecular ...
AD Karakaplan, AY Grosberg, Cornelis Storm, D Morse, DA Head, F Gittes, F Gittes, F MacKintosh, F. C. MacKintosh, J Marko, J Wilhelm, J Wilhelm, J Xu, Jennifer J. Pastore, JF Leterrier, JO Hjortdal, JV Shah, K Kroy, L Ma, LD Landau, LD Landau, LRG Treloar, LZ Wang, M Fixman, ML Gardel, PA Janmey, PA Janmey, PA Janmey, PA Janmey, Paul A. Janmey, RE Shadwick, SB Smith, T. C. Lubensky, Y Fung   +33 more
core   +2 more sources

IS VIMENTIN THE CAUSE OR EFFECT OF OBSTRUCTIVE SLEEP APNEA DEVELOPMENT? [PDF]

, 2020
Buğra Kerget, Dursun Erol Afşin, Ferhan Kerget, Ömer Araz, Metin Akgün   +4 more
openalex   +1 more source