Results 81 to 90 of about 188,914 (350)

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages

Journal of Innate Immunity, 2019
Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune and proinflammatory cytokine interleukin-1β (IL-1β).
Chih-Ming Tsai, Angelica M. Riestra, Syed Raza Ali, Jerry J. Fong, Janet Z. Liu, Gillian Hughes, Ajit Varki, Victor Nizet   +7 more
doaj   +1 more source

Analysis of epithelial–mesenchymal transition markers in psoriatic epidermal keratinocytes [PDF]

Open Biology, 2015
Psoriasis is similar to endpoints of epithelial–mesenchymal transition (EMT), a process of epithelial cells transformed into fibroblast-like cells. The molecular epithelial and mesenchymal markers were analysed in psoriatic keratinocytes.
Xiao-Yong Man, Xi-Bei Chen, Wei Li, Lilla Landeck, Ting-Ting Dou, Jia-qi Chen, Jiong Zhou, Sui-Qing Cai, Min Zheng   +8 more
doaj   +1 more source

Impact of chronic exposure to bevacizumab on EpCAM-based detection of circulating tumor cells [PDF]

, 2015
BACKGROUND: Circulating tumor cells (CTCs) are often undetected through the immunomagnetic epithelial cell adhesion molecule (EpCAM)-based CellSearch(®) System in breast and colorectal cancer (CRC) patients treated with bevacizumab (BEV), where low ...
GAZZANIGA, PAOLA, GRADILONE, Angela, LOTTI, Lavinia Vittoria, MASSIMI, ISABELLA, NICOLAZZO , CHIARA, PULCINELLI, FABIO MARIA, RAIMONDI, CRISTINA, Vespa, Simone   +7 more
core   +1 more source

An In Situ Embedded B‐MOF Sponge With Shape‐Memory for All‐in‐One Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
A smart shape‐memory sponge dressing (P1A3@B‐MOF) is developed for accelerated diabetic wound healing. It achieves pH‐responsive corelease of Zn2+ and salvianolic acid B, synergistically providing antibacterial action, repolarizing macrophages to the M2 phenotype, and promoting angiogenesis.
Hai Zhou, Chaoyang Huang, Yanqi Chen, Tingzi Zhao, Fengyi Zhu, Gong Jun, Jinrong Zhang, Yingsong Pan, Qiulan Wen, Lei Yang, Huihui Zhang, Lianglong Chen   +11 more
wiley   +1 more source

Subcellular Localization of Sprouty2 in Human Glioma Cells

Frontiers in Molecular Neuroscience, 2019
Sprouty proteins act ubiquitously as signaling integrators and inhibitors of receptor tyrosine kinase (RTK) activated pathways. Among the four Sprouty isoforms, Sprouty2 is a key regulator of growth factor signaling in several neurological disorders ...
Barbara Hausott, Jong-Whi Park, Taras Valovka, Martin Offterdinger, Michael W. Hess, Stephan Geley, Lars Klimaschewski   +6 more
doaj   +1 more source

Compartmentalisation and localisation of the translation initiation factor (eIF) 4F complex in normally growing fibroblasts [PDF]

, 2006
Previous observations of association of mRNAs and ribosomes with subcellular structures highlight the importance of localised translation. However, little is known regarding associations between eukaryotic translation initiation factors and cellular ...
Barbarese, Bassell, Bergamini, Biegel, Bonneau, Bushell, Bushell, Caron, Carson, Cervera, Chicurel, Clore, Coldwell, Cowan, Cuesta, Culjkovic, Dang, Delom, Farina, Farmer, Hamill, Hasek, Hill, Hou, Hovland, Hudder, Jansen, Jansen, Jockusch, Kedersha, Kedersha, Kedersha, Kedersha, Kim, Kimball, Kislauskis, Kloc, Latham, Lemieux, Lenk, Lerner, Lerner, Levadoux, Lin, Lindemann, Liu, Mark Willett, Mickleburgh, Micklem, Moore, Moore, Munshi, Murray, Negrutskii, Negrutskii, Negrutskii, Nicchitta, Ornelles, Palacek, Patrick, Pincheira, Prahlad, Pramanik, Prevot, Ramaekers, Shestakova, Simon A. Flint, Simon J. Morley, Smart, Stapulionis, Stapulionis, Svitkin, Svitkin, Taneja, Thoma, Traub, Trombetta, Umikawa, Valouev, van Venrooij, Virginia M. Pain, Wang, Woods   +82 more
core   +1 more source

Cancer Cells Traverse Faster in Confined Space by Modifying Vimentin filaments With Nuclear Deformation and Promoting the Growth of Desired Tumor Spheroids

Advanced Materials Interfaces, EarlyView.
This study demonstrates how the Vimentin intermediate (VIM) filaments distribution/density regulates the attainment of different migration modes through cytoskeleton rearrangement and controls the nuclear morphology in migrating cells under physical confinement, which facilitates the faster traversing of those cells and the growth of post‐migration ...
Md Kowsar Alam, Jiao Zhai, Heng Zou, Yu Chen, Michael Yang   +4 more
wiley   +1 more source

Alveolar rhabdomyosarcoma in a dog confirmed using myogenin immunohistochemistry: a case report

Veterinární Medicína, 2016
A large mass from the right forelimb of a five-year-old, male, Maltese dog, was resected surgically and examined histopathologically. Grossly, the 4 × 6 cm mass was well-demarcated and firm.
J.K. Park, E.M. Lee, A.Y. Kim, E.J. Lee, I.H. Hong, M.R. Ki, K.S. Jeong   +6 more
doaj   +1 more source

The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken [PDF]

, 2005
The replacement histone H2A.Z is variously reported as being linked to gene expression and preventing the spread of heterochromatin in yeast, or concentrated at heterochromatin in mammals.
Bonifer, C., Bruce, K., Crane-Robinson, C., Greaves, I., Lefevre, P., Mantouvalou, E., Myers, F.A., Thorne, A.W., Tremethick, D.J.   +8 more
core   +5 more sources