Results 111 to 120 of about 31,171 (226)
Reversing the peptide backbone sequence of novel tryptophyl‐dipeptides uncovers profound changes in synthetic accessibility and antineoplastic profiles against human solid tumors. Phenotypic screening identifies a conformationally restricted lead architecture that achieves sub‐micromolar growth inhibition, confirming sequence topology as a critical ...
J. Benamer Díaz +3 more
wiley +1 more source
Objectives To review how response to neoadjuvant therapy (NAT) is assessed in clinical trials of muscle‐invasive bladder cancer (MIBC), and to determine whether trial‐derived evidence can inform response evaluation in contemporary practice. Subjects/Patients and Methods We searched PubMed, Embase and ClinicalTrials.gov through August 2025 for ...
Roberto Contieri +9 more
wiley +1 more source
Abstract Background Data on chemotherapeutic efficacy and tolerability for Kaposi Sarcomas (KS) in people living with HIV (PWH) and HIV‐virological control are limited. We aimed to describe clinical responses and tolerability of KS therapies in PWH with HIV‐aviraemic KS in a prospective cohort.
S. Bacquart +10 more
wiley +1 more source
The effects of a staurosporine derivative, N-ethoxycarbonyl-7-oxostaurosporine (NA-382), on the pharmacokinetics of vinblastine were evaluated, compared with those of verapamil, in multidrug-resistant P388/ADR-bearing mice.
Shinya Wakusawa +4 more
core +1 more source
STUDY OF STABILITY OF CELL CARRIERS AND CELLULAR FORMS OF VINKRISTIN AND VINBLASTIN IN STORAGE
Employees of the department of pharmaceutical chemistry and phar-maceutical technology received modified forms of terpene-indole alkaloids (TIA) - vincristine (VCR) and vinblastine (VBL) known in the therapy of oncological diseases by incorporating them ...
O. V. Trineeva, A. J. Halahakoon
doaj
Tumor growth delay and cell survival after treatment with irradiation and vinblastine
The interaction of irradiation and vinblastine was investigated in a solid rat rhabdomyosarcoma. Growth delay of the tumor and cell survival by an in vitro assay were the endpoints measured. Vinblastine was administered at a dose of 1.5 mg/kg body weight
Janse, H.C., Kal, H.B., Barendsen, G.W.
core +1 more source
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects.
Maryam Moudi +3 more
doaj
. The amino acids glutamic acid and tryptophan reportedly reverse the antitumour effect of the cancer chemotherapeutic drug vinblastine. Recent studies have shown that a large part of vinblastine's antitumour effect is due to induction of apoptosis.
Ishii, H., Allan, D. J., Harmon, B. V.
core +1 more source

