Results 91 to 100 of about 44,757 (227)
Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells [PDF]
, 2006 Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant cancers but there is little known ...
A Ibrahim +58 more
core +2 more sources
Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma
Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano +7 more
wiley +1 more source
A case of multisystem Langerhans cell histiocytosis presenting as central diabetes insipidus
Journal of Community Hospital Internal Medicine Perspectives, 2019 Langerhans cell histiocytosis (LCH) is a rare malignancy most commonly characterized by histiocytic infiltration of bone. LCH lesions in the skull place the adjacent central nervous system (CNS) at risk for involvement, which can manifest as central ...
P. Daniel Nicholas, Ian Garrahy
doaj +1 more source
Orphanet Journal of Rare Diseases, 2017 Background Vinblastine is the standard treatment for children with Langerhans cell histiocytosis (LCH). Whether this treatment could be extended to adults with LCH is questionable.
Abdellatif Tazi +14 more
doaj +1 more source
Genomic analyses of microdissected Hodgkin and Reed-Sternberg cells: mutations in epigenetic regulators and p53 are frequent in refractory classic Hodgkin lymphoma [PDF]
, 2019 This work was supported by grants from the Plan Nacional de I + D + I cofinanced by the ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER), PI12/1832, the Spanish Association for Cancer Research (AECC), and ...
Astudillo, Aurora +11 more
core +2 more sources
International Journal of Cancer, Volume 158, Issue 10, Page 2674-2683, 15 May 2026.What's new? Mitogen‐activated protein kinase (MAPK) inhibitors are promising treatments for pediatric Langerhans cell histiocytosis (LCH), a rare heterogeneous neoplasm that often affects multiple organ systems. Which MAPK inhibitors are most effective against LCH remains uncertain.
Xue Tang +5 more
wiley +1 more source
High efficacy and low toxicity of weekly docetaxel given as first-line treatment for metastatic breast cancer [PDF]
, 2005 Background: Docetaxel is one of the most effective antitumor agents currently available for the treatment of metastatic breast cancer (MBC). This phase II multicenter study prospectively analyzed the efficacy and toxicity of docetaxel given on a weekly ...
Ajani JA +26 more
core +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.This review highlights the evolution of highly enantioselective oxazolidinone transformations enabled by C2‐symmetric ligands, with emphasis on chiral iron triad complexes as cost‐effective, environmentally benign alternatives to late‐transition‐metal catalysts.
Arthur David, Thierry Ollevier
wiley +1 more source
مجلة مركز بحوث التقنيات الاحيائية, 2010 The aim of this study was to determine the effect of chemotherapy (vincristine and vinblastine) on the fertility and sex hormones level of female mice. Twenty four female albino mice were divided into three equal groups.
Hazim I. A. Al-Ahmed
doaj +1 more source
Protein kinase a distribution differentiates human glioblastoma from brain tissue [PDF]
, 2017 Brain tumor glioblastoma has no clear molecular signature and there is no effective therapy. In rodents, the intracellular distribution of the cyclic AMP (cAMP)-dependent protein kinase (Protein kinase A, PKA) R2Alpha subunit was previously shown to ...
Caretta, Antonio +3 more
core +2 more sources