Results 71 to 80 of about 31,171 (226)

Vinblastine for recurrent Hodgkin's disease following autologous bone marrow transplant.

, 1998
PURPOSE Bone marrow transplant (BMT) can cure recurrent Hodgkin's disease, but more than half of patients will progress and require additional treatment. When this occurs, there are no curative options and palliative therapy is usually indicated. In such
R Little, W H Wilson, R E Wittes, D L Longo   +3 more
core   +1 more source

Survival outcomes in dogs treated with vinorelbine‐based adjuvant treatment following surgical resection of grade II and III pulmonary carcinoma

Journal of Small Animal Practice, EarlyView.
Objectives Pulmonary carcinoma in dogs is commonly managed with surgical resection; however, the role of adjuvant chemotherapy for grade II and III carcinomas remains unclear. This retrospective multicentre study investigated the outcomes in dogs treated with vinorelbine‐based adjuvant treatment (as monotherapy or combined chemotherapy) following ...
N. Wong, L. Brockley, S. Rajan, J. Yu
wiley   +1 more source

Effect of Photobiomodulation on Vinblastine-Poisoned Murine HERS Cells [PDF]

, 2010
Objective: The aim of this study was to investigate the effect of near-infrared (NIR) photobiomodulation on the proliferation and glutathione levels in murine Hertwig\u27s epithelial root sheath (HERS) cells after poisoning with vinblastine.
Buchmann, E., Whelan, Harry T., Hodgson, Brian D., Henry, Michele M, Pyszka, B.   +4 more
core  

Structural basis for the regulation of tubulin by vinblastine

, 2005
International audienceVinblastine is one of several tubulin-targeting Vinca alkaloids that have been responsible for many chemotherapeutic successes since their introduction in the clinic as antitumour drugs.
Michel O. Steinmetz, Marcel Knossow, Wang, Chunguang, Roussi, Fanny, Chunguang Wang, Patrick A. Curmi, Ravelli, Raimond, Gigant, Benoît, Benoît Gigant, Fanny Roussi, Knossow, Marcel, André Sobel, Raimond B. G. Ravelli, Steinmetz, Michel,, Curmi, Patrick,, Sobel, André   +15 more
core   +1 more source

Preliminary Comparison of Competitive Efflux and Historical Transwell Assays for Assessing Canine P‐Glycoprotein Substrate Status of Eleven Drugs Representing Ten Different Drug Classes

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Because P‐glycoprotein (P‐gp) influences the disposition of substrate drugs, regulatory agencies recommend ascertaining the P‐gp substrate status of active pharmaceutical ingredients (API's) intended for humans. Transwell‐based assays using P‐gp‐overexpressing human cell lines are routinely used to predict the API's P‐gp substrate status ...
K. L. Mealey, N. S. Burke
wiley   +1 more source

PHOTOCHEMICAL INVESTIGATION OF VINBLASTINE IN 43 CULTIVARS OF CATHARANTHUS ROSEUS L.

Journal of Research in Medical Sciences, 2000
Background. Vinblastine is one of the alkaloids extracted from Catharanthus roseus L. which is used for the treatment of Hodgkin's disease, lymphoma, and leukemia in children.
S.E AJADI, R VERPOORTE
doaj  

Vinblastine monotherapy induction prior to radiotherapy for patients with intracranial germinoma during the COVID‐19 pandemic

, 2022
Background: Patientswith localized intracranial germinoma have excellent survival. Reducing treatment burden and long-term sequelae is a priority. Intensive inpatient chemotherapy (e.g., carboPEI = carboplatin/etoposide/ifosfamide) has been effectively ...
English, Martin, Ajithkumar, Thankamma, Nicholson, James C., Matthew J. Murray, Jennifer Adamski, Burke, G. A.Amos; id_orcid, Rafael Moleron, Martin English, G. A. Amos Burke, Cross, Justin, Sara Stoneham, Stoneham, Sara, Murray, Matthew J., Moleron, Rafael, Justin Cross, Thankamma Ajithkumar, James C. Nicholson, Adamski, Jennifer   +17 more
core   +1 more source

Pediatric Langerhans Cell Histiocytosis Presenting With Bilateral Parotid Gland Swelling and Cystic Lung Disease: A Case Report and Literature Review

Pediatric Dermatology, EarlyView.
ABSTRACT Langerhans cell histiocytosis (LCH) is a neoplastic process originating from immature myeloid precursor cells. In this report, we describe a case of a 17‐month‐old with scaling of the scalp and swelling of the bilateral parotid glands who developed acute respiratory distress.
Aretha On, Robert Smith, Robert Duffy, Maria B. Queenan, Melinda Jen   +4 more
wiley   +1 more source

Cellular-Resistance to Vinblastine Is Associated with Altered Respiratory-Function

, 1986
Human leukaemic T lymphoblasts made resistant to low levels (20-40 ng/ml) of vinblastine have altered respiratory capacity. Cellular oxygen uptake was greater in resistant cells compared with sensitive cells, and vinblastine (40 ng/ml) caused immediate ...
Romeo, T, Wright, L.C., Mountford, C.E., Dyne, M, Mountford, CE, Romeo, T., Holmes, K.T., Wright, LC, Dyne, M., Holmes, KT   +9 more
core  

Ansamitocin and maytansine bind at the vinblastine binding pocket in tubulin dimer.

, 2013
(A) Structures of vinblastine (Pink), ansamitocin P3 (brown) and maytansine (blue) are shown. (B) Surface view of α-β tubulin dimer, α chain is shown in hydrophobic surface while β chain is shown in cyan color.
Jubina B. Venghateri (466690), Tilak Kumar Gupta (466691), Ambarish Kunwar (466692), Paul J. Verma (133316), Dulal Panda (139739)   +4 more
core   +1 more source