Results 51 to 60 of about 44,757 (227)

Oncolytic herpes viruses, chemotherapeutics, and other cancer drugs [PDF]

, 2013
Oncolytic viruses are emerging as a potential new way of treating cancers. They are selectively replication-competent viruses that propagate only in actively dividing tumor cells but not in normal cells and, as a result, destroy the tumor cells by ...
Braidwood, L., Conner, J., Graham, A., Graham, S.V.   +3 more
core   +1 more source

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, EarlyView.
What's New? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

The terpene-indole alkaloids loaded erythrocytes as a drug carrier: design and assessment

Russian Open Medical Journal, 2018
The aim of this work was to elucidate the certain parameters (morphological, physicochemical) of terpene-indole alkaloids (TIAs) encapsulated human erythrocytes as a drug delivery system, and in addition to providing insight into the functional state of ...
Halahakoon Mudiyanselge Amila Jeewantha, Aleksei I. Slivkin   +1 more
doaj   +1 more source

Changing in the production of anticancer drugs (vinblastine and vincristine) in Catharanthus roseus (L.) G. Don by potassium and ascorbic acid treatments

Plant, Soil and Environment, 2022
Catharanthus roseus seedling was treated with different concentrations (1.5, 3.16, 15, and 30 mmol) and forms (K2SO4 and KNO3) of potassium (K+) via Hoagland's nutrient solution. Ascorbic acid (AsA) was sprayed twice (plant days 68 and 78) with different
Neda Sahi, Akbar Mostajeran, Mustafa Ghanadian   +2 more
doaj   +1 more source

Systemic and Local Adiposity in the Bone Marrow Microenvironment Associated With Improved Prognosis in Hodgkin Lymphoma: Imaging and Molecular Analysis

International Journal of Cancer, EarlyView.
Schematic overview of systemic and bone marrow‐specific adiposity in Hodgkin Lymphoma (HL). Body Mass Index was associated with bone marrow (BM) involvement, relapse, and mortality (1). In contrast, increased yellow marrow density was associated with poorer prognosis (2).
Andreia Matos, William P. Cawthorn, Joana Marinho‐Dias, Sofia Ramalheira, Susana Roncon, Dulcineia Pereira, Teresa Ribeiro, Carla Rodrigues, Mário Mariz, Ana Miranda, Helena Brízido, Manuel Bicho, Pedro Medeiros, Ana Carneiro, Fernanda Trigo, Pingzhao Hu, Flávia Pereira, Hugo Duarte, Calum D. Gray, Tom Macgillivray, Alan G. Ramsay, Maria J. Oliveira, Ricardo Ribeiro   +22 more
wiley   +1 more source

Effects of PEG-induced drought stress on regulation of indole alkaloid biosynthesis in Catharanthus roseus

Journal of Plant Interactions, 2017
Catharanthus roseus (C. roseus) plants were used to investigate the terpenoid indole alkaloids (TIAs) accumulation under the condition of PEG-induced drought stress.
Ying Liu, Qinghuan Meng, Xihua Duan, Zhonghua Zhang, Dewen Li   +4 more
doaj   +1 more source

Mechanism Underlying the Reversal of Drug Resistance in P-Glycoprotein-Expressing Leukemia Cells by Pinoresinol and the Study of a Derivative [PDF]

, 2017
P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading to a cellular response that hinders efforts toward successful ...
Carpinella, Maria Cecilia, Gancedo, Samanta, González, María Laura, Joray, Mariana Belén, Laiolo, Jerónimo, Lanza Castronuovo, Priscila Ailin, Maccioni, Mariana, Molina, Gabriela, Palacios, Sara Maria, Rumjanek, Vivian, Vera, Domingo Mariano Adolfo   +10 more
core   +2 more sources

Lymphocyte Micronucleus Formation Is Driven by Inflammation‐Induced Oxidative DNA Damage in Oesophageal Cancer Development

International Journal of Cancer, EarlyView.
Chromosomal instability is a hallmark of cancer, but minimally invasive ways to detect systemic DNA damage and cancer risk remain limited. Here, using patient blood samples, the authors investigated lymphocyte micronuclei (MN) frequency as a potential marker of DNA damage across the progression from gastroesophageal reflux disease to Barrett's ...
Kathryn Munn, Rachel Lawrence, Hasan Haboubi, Hamsa Naser, Kate Hurlow, Ume‐Kulsoom Shah, Lisa Williams, Sarah Gwynne, Owen Bodger, Jiri Zavadil, Francois Virard, Shareen Doak, Laura E. Thomas, Gareth Jenkins   +13 more
wiley   +1 more source

Current status of herbal and their future perspectives [PDF]

, 2007
Traditional medicine is the synthesis of therapeutic experience of generations of practicing physicians of indigenous systems of medicine. Throughout the history of mankind, many infectious diseases have been treated with herbals.
Ponnampalam Gopalakrishnakone, Ramar Perumal R. Samy   +1 more
core   +1 more source

Autophagy and urothelial carcinoma of the bladder: A review. [PDF]

, 2016
The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the
Chandrasekar, Thenappan, Evans, Christopher P   +1 more
core   +2 more sources